Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CPNE3

Summary for CPNE3

Gene information	Gene symbol	CPNE3
	Ensembl ID	ENSG00000085719
	Entrez ID	8895
	Gene name	copine 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O75131

Top

Dataset with differentially expressed gene: CPNE3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.263487	1.55e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.409107	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.379049	3.75e-32

Top

Expression of CPNE3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CPNE3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CPNE3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CPNE3	hsa-miR-3163	99.8251	NM_003909
CPNE3	hsa-miR-548ar-3p	98.2292	NM_003909
CPNE3	hsa-miR-548f-3p	97.4636	NM_003909
CPNE3	hsa-miR-548bc	97.4636	NM_003909
CPNE3	hsa-miR-548e-3p	97.4636	NM_003909
CPNE3	hsa-miR-548az-3p	97.4636	NM_003909
CPNE3	hsa-miR-548a-3p	97.218	NM_003909
CPNE3	hsa-miR-548c-3p	97.141	NM_003909
CPNE3	hsa-miR-493-5p	95.5858	NM_003909
CPNE3	hsa-miR-95-5p	94.4883	NM_003909
CPNE3	hsa-miR-186-5p	94.0873	NM_003909
CPNE3	hsa-miR-3692-3p	93.4133	NM_003909
CPNE3	hsa-miR-6835-5p	91.7944	NM_003909
CPNE3	hsa-miR-4495	91.086	NM_003909
CPNE3	hsa-miR-335-3p	91.0851	NM_003909
CPNE3	hsa-miR-6812-5p	90.8876	NM_003909
CPNE3	hsa-miR-627-3p	90.7815	NM_003909
CPNE3	hsa-miR-6737-5p	90.5995	NM_003909
CPNE3	hsa-miR-6819-5p	90.5995	NM_003909
CPNE3	hsa-miR-5587-5p	90.5337	NM_003909
CPNE3	hsa-miR-196a-1-3p	90.0176	NM_003909
CPNE3	hsa-miR-124-3p	89.8628	NM_003909
CPNE3	hsa-miR-506-3p	89.8628	NM_003909
CPNE3	hsa-miR-5003-3p	89.6651	NM_003909
CPNE3	hsa-miR-5007-3p	88.9603	NM_003909
CPNE3	hsa-miR-576-5p	88.5455	NM_003909
CPNE3	hsa-miR-32-3p	88.4628	NM_003909
CPNE3	hsa-miR-3658	88.313	NM_003909
CPNE3	hsa-miR-133a-3p	87.6059	NM_003909
CPNE3	hsa-miR-133b	87.6059	NM_003909
CPNE3	hsa-miR-12136	87.1032	NM_003909
CPNE3	hsa-miR-580-3p	85.767	NM_003909
CPNE3	hsa-miR-302a-5p	84.7784	NM_003909
CPNE3	hsa-miR-586	84.2999	NM_003909
CPNE3	hsa-miR-3662	84.2599	NM_003909
CPNE3	hsa-miR-548g-3p	83.7763	NM_003909
CPNE3	hsa-miR-3671	83.7171	NM_003909
CPNE3	hsa-miR-4328	83.4397	NM_003909
CPNE3	hsa-miR-4311	83.3828	NM_003909
CPNE3	hsa-miR-3978	83.2054	NM_003909
CPNE3	hsa-miR-508-3p	83.0854	NM_003909
CPNE3	hsa-miR-5011-5p	82.7813	NM_003909
CPNE3	hsa-miR-1245b-3p	82.2524	NM_003909
CPNE3	hsa-miR-3646	82.1911	NM_003909
CPNE3	hsa-miR-570-3p	81.606	NM_003909

Page: 1

Top

Motifs and transcription factors (TFs) regulating CPNE3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CPNE3	transfac_pro__M04817	ZBTB33 (directAnnotation).
CPNE3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."