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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CLINT1

Summary for CLINT1

Gene information	Gene symbol	CLINT1
	Ensembl ID	ENSG00000113282
	Entrez ID	9685
	Gene name	clathrin interactor 1
	Synonyms	CLINT\|ENTH\|EPNR\|KIAA0171
	Gene type	protein_coding
	UniProtAcc	Q14677

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Dataset with differentially expressed gene: CLINT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.556531	2.68e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.716034	1.75e-33
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.589711	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.54014	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.427638	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.273622	1.52e-28
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.372293	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.367193	1.21e-14

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Expression of CLINT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CLINT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CLINT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CLINT1	hsa-miR-3163	99.9849	NM_001195555
CLINT1	hsa-miR-4282	98.7286	NM_001195555
CLINT1	hsa-miR-944	95.2164	NM_001195555
CLINT1	hsa-miR-34b-3p	95.0271	NM_001195555
CLINT1	hsa-miR-5692a	94.73	NM_014666
CLINT1	hsa-miR-5002-3p	94.3198	NM_014666
CLINT1	hsa-miR-551b-5p	94.3077	NM_001195555
CLINT1	hsa-miR-659-3p	94.0293	NM_014666
CLINT1	hsa-miR-1277-5p	93.6432	NM_001195555
CLINT1	hsa-miR-3924	93.5044	NM_001195555
CLINT1	hsa-miR-5011-5p	93.2004	NM_001195555
CLINT1	hsa-miR-3148	92.4195	NM_001195555
CLINT1	hsa-miR-4520-2-3p	92.3377	NM_001195555
CLINT1	hsa-miR-95-5p	92.1867	NM_014666
CLINT1	hsa-miR-6124	91.9688	NM_001195555
CLINT1	hsa-miR-4775	91.3442	NM_001195555
CLINT1	hsa-miR-4668-3p	90.5756	NM_001195555
CLINT1	hsa-miR-6782-3p	90.022	NM_001195555
CLINT1	hsa-miR-4520-3p	89.4587	NM_001195555
CLINT1	hsa-miR-7977	89.2613	NM_014666
CLINT1	hsa-miR-548f-5p	89.1464	NM_001195555
CLINT1	hsa-miR-548g-5p	89.1464	NM_001195555
CLINT1	hsa-miR-548x-5p	89.1464	NM_001195555
CLINT1	hsa-miR-548aj-5p	89.1464	NM_001195555
CLINT1	hsa-miR-548p	88.9894	NM_001195555
CLINT1	hsa-miR-1305	88.8986	NM_014666
CLINT1	hsa-miR-653-5p	88.7682	NM_014666
CLINT1	hsa-miR-5681a	88.1353	NM_001195555
CLINT1	hsa-miR-5001-3p	87.8639	NM_014666
CLINT1	hsa-miR-433-3p	86.9734	NM_001195555
CLINT1	hsa-miR-5585-5p	86.5907	NM_001195555
CLINT1	hsa-miR-340-5p	86.0788	NM_001195555
CLINT1	hsa-miR-4496	85.6908	NM_001195555
CLINT1	hsa-miR-580-5p	84.3096	NM_014666
CLINT1	hsa-miR-548c-3p	83.9577	NM_001195555
CLINT1	hsa-miR-218-1-3p	83.1569	NM_014666
CLINT1	hsa-miR-510-3p	82.7878	NM_014666
CLINT1	hsa-miR-153-5p	80.6501	NM_001195555

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Motifs and transcription factors (TFs) regulating CLINT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CLINT1	tfdimers__MD00038	TFAP2C (directAnnotation).
CLINT1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CLINT1	metacluster_198.3	ZFP64 (directAnnotation).
CLINT1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CLINT1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CLINT1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CLINT1	cisbp__M00788	ZFY (inferredBy_Orthology).
CLINT1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CLINT1	metacluster_175.1	ZNF283 (directAnnotation).
CLINT1	hdpi__ZNF304	ZNF304 (directAnnotation).
CLINT1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CLINT1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CLINT1	transfac_pro__M01199	TRIM28 (directAnnotation).
CLINT1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CLINT1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CLINT1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CLINT1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CLINT1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CLINT1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CLINT1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CLINT1	jaspar__MA1721.1	ZNF93 (directAnnotation).
CLINT1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CLINT1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CLINT1	transfac_pro__M01253	CNOT3 (directAnnotation).
CLINT1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CLINT1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CLINT1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CLINT1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CLINT1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CLINT1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CLINT1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CLINT1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
CLINT1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
CLINT1	transfac_pro__M07310	SP5 (directAnnotation).
CLINT1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CLINT1	transfac_pro__M00938	E2F1 (directAnnotation).
CLINT1	tfdimers__MD00364	WT1 (directAnnotation).
CLINT1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CLINT1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CLINT1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
CLINT1	transfac_pro__M01973	PLAG1 (directAnnotation).
CLINT1	transfac_pro__M01303	SP1 (directAnnotation).
CLINT1	metacluster_143.13	ZBTB7A (directAnnotation).
CLINT1	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
CLINT1	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
CLINT1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
CLINT1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CLINT1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
CLINT1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
CLINT1	transfac_pro__M00514	ATF4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."