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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHURC1

Summary for CHURC1

Gene information	Gene symbol	CHURC1
	Ensembl ID	ENSG00000258289
	Entrez ID	91612
	Gene name	churchill domain containing 1
	Synonyms	C14orf52\|FLJ33064\|My015
	Gene type	protein_coding
	UniProtAcc	Q8WUH1

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Dataset with differentially expressed gene: CHURC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.807284	1.28e-13
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	-0.318287	5.00e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.656539	3.40e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.368996	1.06e-37

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Expression of CHURC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHURC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHURC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHURC1	hsa-miR-4795-3p	97.3618	NM_145165
CHURC1	hsa-miR-4729	97.1335	NM_145165
CHURC1	hsa-miR-670-3p	95.4062	NM_145165
CHURC1	hsa-miR-30d-3p	90.7594	NM_145165
CHURC1	hsa-miR-30e-3p	90.7594	NM_145165
CHURC1	hsa-miR-30a-3p	90.7594	NM_145165
CHURC1	hsa-miR-6508-5p	89.3456	NM_001204064
CHURC1	hsa-miR-126-5p	88.88	NM_145165
CHURC1	hsa-miR-302e	88.5752	NM_145165
CHURC1	hsa-miR-1250-3p	88.018	NM_145165
CHURC1	hsa-miR-8067	87.3808	NM_001204064
CHURC1	hsa-miR-186-5p	84.2779	NM_145165
CHURC1	hsa-miR-8057	83.8707	NM_145165
CHURC1	hsa-miR-27a-5p	82.5159	NM_145165
CHURC1	hsa-miR-544a	81.4273	NM_145165
CHURC1	hsa-miR-5696	80.8436	NM_145165
CHURC1	hsa-miR-6079	80.6165	NM_145165

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Motifs and transcription factors (TFs) regulating CHURC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHURC1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CHURC1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
CHURC1	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
CHURC1	transfac_pro__M06513	ZFP90 (directAnnotation).
CHURC1	transfac_pro__M06267	ZNF805 (directAnnotation).
CHURC1	metacluster_122.17	IRF6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."