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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHORDC1

Summary for CHORDC1

Gene information	Gene symbol	CHORDC1
	Ensembl ID	ENSG00000285023
	Entrez ID	26973
	Gene name	cysteine and histidine rich domain containing 1
	Synonyms	CHP-1\|CHP1
	Gene type	protein_coding
	UniProtAcc	Q9UHD1

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Dataset with differentially expressed gene: CHORDC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.450915	5.39e-26
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.338809	3.91e-11
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.479844	1.16e-34
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.591204	6.36e-14
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.653084	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-0.390789	6.02e-23
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.500088	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.2879	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.36558	4.51e-25
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.401435	9.32e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.399839	9.22e-26
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.481504	5.84e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.752108	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.322032	0.00e+00

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Expression of CHORDC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHORDC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHORDC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHORDC1	hsa-miR-6867-5p	99.3917	NM_001144073
CHORDC1	hsa-miR-1297	98.9783	NM_001144073
CHORDC1	hsa-miR-26a-5p	98.5408	NM_001144073
CHORDC1	hsa-miR-26b-5p	98.5408	NM_001144073
CHORDC1	hsa-miR-539-5p	98.1746	NM_001144073
CHORDC1	hsa-miR-194-5p	98.0924	NM_001144073
CHORDC1	hsa-miR-4465	97.8548	NM_001144073
CHORDC1	hsa-miR-4307	95.9535	NM_001144073
CHORDC1	hsa-miR-6760-5p	94.2859	NM_001144073
CHORDC1	hsa-miR-3529-3p	93.8115	NM_001144073
CHORDC1	hsa-miR-506-5p	93.2891	NM_001144073
CHORDC1	hsa-miR-6844	93.069	NM_001144073
CHORDC1	hsa-miR-5580-3p	92.9223	NM_001144073
CHORDC1	hsa-miR-552-5p	92.6337	NM_001144073
CHORDC1	hsa-miR-3065-5p	92.5743	NM_001144073
CHORDC1	hsa-miR-5697	91.2787	NM_001144073
CHORDC1	hsa-miR-302c-5p	90.1796	NM_001144073
CHORDC1	hsa-miR-6878-5p	89.8828	NM_001144073
CHORDC1	hsa-miR-4804-3p	88.9957	NM_001144073
CHORDC1	hsa-miR-338-5p	86.6857	NM_001144073
CHORDC1	hsa-miR-4275	86.5587	NM_001144073
CHORDC1	hsa-miR-518d-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-519c-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-518f-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-526a-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-519b-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-520c-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-519a-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-523-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-522-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-518e-5p	86.1477	NM_001144073
CHORDC1	hsa-miR-590-3p	85.2346	NM_001144073
CHORDC1	hsa-miR-3657	84.9365	NM_001144073
CHORDC1	hsa-miR-6732-3p	83.4681	NM_001144073
CHORDC1	hsa-miR-3671	83.3605	NM_001144073
CHORDC1	hsa-miR-137-3p	82.0099	NM_001144073
CHORDC1	hsa-miR-4666a-5p	81.8569	NM_001144073
CHORDC1	hsa-miR-1278	81.8406	NM_001144073
CHORDC1	hsa-miR-498-5p	81.5702	NM_001144073
CHORDC1	hsa-miR-584-5p	81.2652	NM_001144073
CHORDC1	hsa-miR-551b-5p	81.1439	NM_001144073
CHORDC1	hsa-miR-548bb-5p	81.0603	NM_001144073
CHORDC1	hsa-miR-4638-3p	80.4294	NM_001144073
CHORDC1	hsa-miR-4775	80.2894	NM_001144073
CHORDC1	hsa-miR-548b-3p	80.1795	NM_001144073

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Motifs and transcription factors (TFs) regulating CHORDC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHORDC1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CHORDC1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CHORDC1	jaspar__MA1708.1	ETV7 (directAnnotation).
CHORDC1	transfac_pro__M04794	TAF1 (directAnnotation).
CHORDC1	hdpi__FLI1	FLI1 (directAnnotation).
CHORDC1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
CHORDC1	transfac_pro__M01298	MECP2 (directAnnotation).
CHORDC1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CHORDC1	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
CHORDC1	transfac_pro__M00492	STAT1 (directAnnotation).
CHORDC1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
CHORDC1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
CHORDC1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CHORDC1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
CHORDC1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CHORDC1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CHORDC1	hdpi__ELF2	ELF2 (directAnnotation).
CHORDC1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
CHORDC1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
CHORDC1	metacluster_183.4	ETS1 (inferredBy_Orthology).
CHORDC1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CHORDC1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CHORDC1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
CHORDC1	jaspar__MA1932.1	HOXB13 (directAnnotation).
CHORDC1	metacluster_81.7	CREB1 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
CHORDC1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
CHORDC1	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CHORDC1	jaspar__MA1483.2	ELF2 (directAnnotation).
CHORDC1	transfac_pro__M05544	BCL11A (directAnnotation).
CHORDC1	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
CHORDC1	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).
CHORDC1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
CHORDC1	jaspar__MA1957.1	ELK1 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
CHORDC1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
CHORDC1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
CHORDC1	jaspar__MA1933.1	SREBF2 (directAnnotation).
CHORDC1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CHORDC1	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).
CHORDC1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
CHORDC1	transfac_pro__M05711	ZNF37A (directAnnotation).
CHORDC1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
CHORDC1	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
CHORDC1	transfac_pro__M05976	ZNF223 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."