Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHMP1B

Summary for CHMP1B

Gene information	Gene symbol	CHMP1B
	Ensembl ID	ENSG00000255112
	Entrez ID	57132
	Gene name	charged multivesicular body protein 1B
	Synonyms	C18orf2\|CHMP1.5\|Vps46B
	Gene type	protein_coding
	UniProtAcc	Q7LBR1

Top

Dataset with differentially expressed gene: CHMP1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	0.292758	1.07e-14
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.438564	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.314182	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.314342	2.10e-37
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.383865	7.46e-08
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-0.427214	1.52e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.483423	3.26e-31
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.371802	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.577742	1.85e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.317772	1.45e-09
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	1.1175	2.99e-27
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.263885	1.01e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.403785	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.254368	9.28e-04
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.252973	1.75e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.328126	6.06e-31
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.585896	0.00e+00

Top

Expression of CHMP1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CHMP1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CHMP1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHMP1B	hsa-miR-4775	98.5978	NM_020412
CHMP1B	hsa-miR-5692a	97.1751	NM_020412
CHMP1B	hsa-miR-3163	96.7667	NM_020412
CHMP1B	hsa-miR-3658	94.1091	NM_020412
CHMP1B	hsa-miR-7847-3p	93.5876	NM_020412
CHMP1B	hsa-miR-4262	93.2187	NM_020412
CHMP1B	hsa-miR-4425	92.7718	NM_020412
CHMP1B	hsa-miR-373-5p	92.4525	NM_020412
CHMP1B	hsa-miR-371b-5p	92.4525	NM_020412
CHMP1B	hsa-miR-616-5p	92.4525	NM_020412
CHMP1B	hsa-miR-488-5p	91.2949	NM_020412
CHMP1B	hsa-miR-181a-5p	90.5139	NM_020412
CHMP1B	hsa-miR-181c-5p	90.5139	NM_020412
CHMP1B	hsa-miR-181d-5p	90.5139	NM_020412
CHMP1B	hsa-miR-181b-5p	90.5139	NM_020412
CHMP1B	hsa-miR-3140-3p	89.5532	NM_020412
CHMP1B	hsa-miR-216a-5p	88.8879	NM_020412
CHMP1B	hsa-miR-1277-5p	88.0169	NM_020412
CHMP1B	hsa-miR-9-5p	87.8342	NM_020412
CHMP1B	hsa-miR-30a-3p	87.6002	NM_020412
CHMP1B	hsa-miR-30d-3p	87.6002	NM_020412
CHMP1B	hsa-miR-30e-3p	87.6002	NM_020412
CHMP1B	hsa-miR-590-3p	87.16	NM_020412
CHMP1B	hsa-miR-4777-5p	84.6753	NM_020412
CHMP1B	hsa-miR-6762-3p	82.6217	NM_020412
CHMP1B	hsa-miR-605-3p	82.2333	NM_020412
CHMP1B	hsa-miR-6809-3p	81.1934	NM_020412
CHMP1B	hsa-miR-3180-5p	80.8087	NM_020412

Page: 1

Top

Motifs and transcription factors (TFs) regulating CHMP1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHMP1B	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
CHMP1B	transfac_pro__M02279	CREB1 (directAnnotation).
CHMP1B	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CHMP1B	cisbp__M01815	CEBPE (inferredBy_Orthology).
CHMP1B	metacluster_70.22	POU3F2 (directAnnotation).
CHMP1B	tfdimers__MD00432	DBP; STAT1 (directAnnotation).
CHMP1B	metacluster_70.21	POU3F1 (directAnnotation).
CHMP1B	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
CHMP1B	transfac_pro__M06845	ZBTB38 (directAnnotation).
CHMP1B	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
CHMP1B	metacluster_22.13	MAFK (inferredBy_Orthology).
CHMP1B	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
CHMP1B	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
CHMP1B	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
CHMP1B	cisbp__M01725	SREBF2 (inferredBy_Orthology).
CHMP1B	jaspar__MA1956.1	FOXO1 (directAnnotation).
CHMP1B	jaspar__MA1954.1	FOXO1 (directAnnotation).
CHMP1B	jaspar__MA1946.1	FOXI1 (directAnnotation).
CHMP1B	jaspar__MA1955.1	FOXO1 (directAnnotation).
CHMP1B	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
CHMP1B	hdpi__TFAM	TFAM (directAnnotation).
CHMP1B	transfac_pro__M06219	ZNF266 (directAnnotation).
CHMP1B	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CHMP1B	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
CHMP1B	transfac_public__M00041	ATF2; JUN (directAnnotation).
CHMP1B	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
CHMP1B	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CHMP1B	transfac_pro__M05402	BCL6B (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."