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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CELF1

Summary for CELF1

Gene information	Gene symbol	CELF1
	Ensembl ID	ENSG00000149187
	Entrez ID	10658
	Gene name	CUGBP Elav-like family member 1
	Synonyms	BRUNOL2\|CUG-BP\|CUGBP\|CUGBP1\|EDEN-BP\|hNab50\|NAB50\|NAPOR
	Gene type	protein_coding
	UniProtAcc	Q92879

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Dataset with differentially expressed gene: CELF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.318891	1.32e-33
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.412773	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.447887	8.68e-31
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.399967	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.293212	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.36483	0.00e+00

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Expression of CELF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CELF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CELF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CELF1	hsa-miR-651-3p	98.6228	NM_198700
CELF1	hsa-miR-520a-5p	96.2796	NM_001172640
CELF1	hsa-miR-525-5p	96.2796	NM_001172640
CELF1	hsa-miR-377-3p	94.7286	NM_001172639
CELF1	hsa-miR-6509-5p	89.8838	NM_001172639
CELF1	hsa-miR-371a-5p	89.7076	NM_198700
CELF1	hsa-miR-9983-3p	89.5054	NM_001172639
CELF1	hsa-miR-3617-3p	88.9479	NM_198700
CELF1	hsa-miR-3529-3p	88.357	NM_001172639
CELF1	hsa-miR-6508-5p	88.3368	NM_001172639
CELF1	hsa-miR-8485	88.3203	NM_198700
CELF1	hsa-miR-3680-3p	88.075	NM_001172640
CELF1	hsa-miR-3148	87.3779	NM_198700
CELF1	hsa-miR-519d-5p	87.2005	NM_001172640
CELF1	hsa-miR-8067	86.6445	NM_001172639
CELF1	hsa-miR-325	86.2421	NM_198700
CELF1	hsa-miR-1302	86.1902	NM_198700
CELF1	hsa-miR-129-5p	84.6732	NM_001172640
CELF1	hsa-miR-4668-3p	83.7937	NM_001172639
CELF1	hsa-miR-4298	83.6071	NM_001172640
CELF1	hsa-miR-5688	83.006	NM_198700
CELF1	hsa-miR-3619-5p	82.8217	NM_001172639
CELF1	hsa-miR-6744-3p	82.803	NM_001172639
CELF1	hsa-miR-4720-3p	82.8001	NM_001172639
CELF1	hsa-miR-105-5p	81.6162	NM_198700
CELF1	hsa-miR-7853-5p	81.6162	NM_198700
CELF1	hsa-miR-6768-5p	81.6091	NM_001172639
CELF1	hsa-miR-510-3p	81.5997	NM_001172639
CELF1	hsa-miR-3613-3p	81.477	NM_001172640
CELF1	hsa-miR-495-3p	81.1235	NM_198700
CELF1	hsa-miR-214-3p	81.0447	NM_001172639
CELF1	hsa-miR-4773	80.2866	NM_001172639

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Motifs and transcription factors (TFs) regulating CELF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CELF1	transfac_pro__M01303	SP1 (directAnnotation).
CELF1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
CELF1	metacluster_143.13	ZBTB7A (directAnnotation).
CELF1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
CELF1	transfac_pro__M07387	ZBTB7A (directAnnotation).
CELF1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
CELF1	transfac_pro__M00665	SP3 (directAnnotation).
CELF1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CELF1	transfac_pro__M02898	SMAD3 (directAnnotation).
CELF1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
CELF1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CELF1	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
CELF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CELF1	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
CELF1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CELF1	transfac_pro__M07329	SP7 (directAnnotation).
CELF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CELF1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CELF1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
CELF1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CELF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CELF1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CELF1	metacluster_84.2	RARA (directAnnotation).
CELF1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
CELF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
CELF1	cisbp__M00341	PAX6 (directAnnotation).
CELF1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CELF1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
CELF1	tfdimers__MD00151	CHURC1 (directAnnotation).
CELF1	tfdimers__MD00391	KLF4 (directAnnotation).
CELF1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
CELF1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
CELF1	transfac_public__M00491	PATZ1 (directAnnotation).
CELF1	transfac_pro__M07397	ZNF148 (directAnnotation).
CELF1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
CELF1	hdpi__TP73	TP73 (directAnnotation).
CELF1	metacluster_141.4	GLIS2 (directAnnotation).
CELF1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CELF1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CELF1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CELF1	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
CELF1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CELF1	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."