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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CDK17

Summary for CDK17

Gene information	Gene symbol	CDK17
	Ensembl ID	ENSG00000059758
	Entrez ID	5128
	Gene name	cyclin dependent kinase 17
	Synonyms	PCTAIRE2\|PCTK2
	Gene type	protein_coding
	UniProtAcc	Q00537

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Dataset with differentially expressed gene: CDK17

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.317628	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.368988	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.328706	1.15e-42
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.270367	8.00e-18
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.304468	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.300252	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.384556	4.20e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.330981	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.459369	0.00e+00

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Expression of CDK17 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK17

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDK17

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK17	hsa-miR-548ap-3p	98.9947	NM_002595
CDK17	hsa-miR-548t-3p	98.9947	NM_002595
CDK17	hsa-miR-548aa	98.9947	NM_002595
CDK17	hsa-miR-196a-1-3p	98.0899	NM_001170464
CDK17	hsa-miR-3691-3p	97.9036	NM_001170464
CDK17	hsa-miR-5047	97.7677	NM_001170464
CDK17	hsa-miR-1301-3p	97.7677	NM_001170464
CDK17	hsa-miR-4504	97.767	NM_002595
CDK17	hsa-miR-5692a	97.7073	NM_002595
CDK17	hsa-miR-433-3p	97.6984	NM_001170464
CDK17	hsa-miR-548as-3p	97.4355	NM_001170464
CDK17	hsa-miR-4719	97.0353	NM_001170464
CDK17	hsa-miR-548ay-3p	96.3641	NM_001170464
CDK17	hsa-miR-548at-3p	96.3641	NM_001170464
CDK17	hsa-miR-590-3p	96.3612	NM_001170464
CDK17	hsa-miR-4282	96.1934	NM_001170464
CDK17	hsa-miR-582-5p	96.1701	NM_001170464
CDK17	hsa-miR-200c-3p	95.8931	NM_001170464
CDK17	hsa-miR-200b-3p	95.8931	NM_001170464
CDK17	hsa-miR-429	95.8931	NM_001170464
CDK17	hsa-miR-4775	95.1294	NM_001170464
CDK17	hsa-miR-7154-5p	94.9687	NM_001170464
CDK17	hsa-miR-1323	94.9234	NM_001170464
CDK17	hsa-miR-5590-3p	94.9043	NM_001170464
CDK17	hsa-miR-142-5p	94.9043	NM_001170464
CDK17	hsa-miR-4698	94.6931	NM_002595
CDK17	hsa-miR-4284	94.6611	NM_001170464
CDK17	hsa-miR-548o-3p	94.502	NM_001170464
CDK17	hsa-miR-576-5p	94.4974	NM_002595
CDK17	hsa-miR-95-5p	94.4714	NM_001170464
CDK17	hsa-miR-3529-3p	93.8457	NM_002595
CDK17	hsa-miR-4262	92.5989	NM_001170464
CDK17	hsa-miR-4789-3p	92.1596	NM_002595
CDK17	hsa-miR-6875-3p	91.0936	NM_001170464
CDK17	hsa-miR-10527-5p	91.085	NM_001170464
CDK17	hsa-miR-548at-5p	90.9921	NM_002595
CDK17	hsa-miR-24-3p	90.9526	NM_001170464
CDK17	hsa-miR-203b-5p	90.9507	NM_001170464
CDK17	hsa-miR-6718-5p	90.9507	NM_001170464
CDK17	hsa-miR-4803	90.7163	NM_001170464
CDK17	hsa-miR-548h-3p	90.5856	NM_001170464
CDK17	hsa-miR-548z	90.5856	NM_001170464
CDK17	hsa-miR-548bb-3p	90.5856	NM_001170464
CDK17	hsa-miR-548d-3p	90.5856	NM_001170464
CDK17	hsa-miR-548ac	90.5856	NM_001170464
CDK17	hsa-miR-199b-3p	90.5841	NM_001170464
CDK17	hsa-miR-199a-3p	90.5841	NM_001170464
CDK17	hsa-miR-552-5p	90.5758	NM_002595
CDK17	hsa-miR-3129-5p	90.3601	NM_001170464
CDK17	hsa-miR-16-2-3p	90.1677	NM_001170464

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Motifs and transcription factors (TFs) regulating CDK17

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDK17	transfac_pro__M04817	ZBTB33 (directAnnotation).
CDK17	transfac_pro__M07310	SP5 (directAnnotation).
CDK17	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CDK17	hdpi__NRL	NRL (directAnnotation).
CDK17	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CDK17	transfac_pro__M07387	ZBTB7A (directAnnotation).
CDK17	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CDK17	transfac_pro__M01783	SP2 (directAnnotation).
CDK17	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CDK17	cisbp__M07938	E2F1 (directAnnotation).
CDK17	tfdimers__MD00483	ZBTB14 (directAnnotation).
CDK17	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CDK17	hdpi__GTF3C2	GTF3C2 (directAnnotation).
CDK17	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CDK17	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
CDK17	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CDK17	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CDK17	transfac_pro__M03806	ZBTB7C (directAnnotation).
CDK17	metacluster_135.11	NR2C2 (directAnnotation).
CDK17	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CDK17	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CDK17	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CDK17	cisbp__M00343	PAX6 (directAnnotation).
CDK17	transfac_pro__M12697	ZNF142 (directAnnotation).
CDK17	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
CDK17	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
CDK17	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CDK17	transfac_pro__M12694	ZFP14 (directAnnotation).
CDK17	transfac_pro__M01253	CNOT3 (directAnnotation).
CDK17	transfac_pro__M04617	ZBTB7A (directAnnotation).
CDK17	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CDK17	transfac_pro__M02090	E2F4 (directAnnotation).
CDK17	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
CDK17	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CDK17	transfac_pro__M07437	ZBTB2 (directAnnotation).
CDK17	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
CDK17	transfac_pro__M00514	ATF4 (directAnnotation).
CDK17	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
CDK17	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CDK17	metacluster_3.10	KLF2; KLF4 (directAnnotation).
CDK17	transfac_pro__M07436	WT1 (directAnnotation).
CDK17	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
CDK17	metacluster_3.14	WT1; WT1 (directAnnotation).
CDK17	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
CDK17	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
CDK17	jaspar__MA1650.1	ZBTB14 (directAnnotation).
CDK17	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDK17	cisbp__M00809	PRDM11 (inferredBy_Orthology).
CDK17	transfac_pro__M00322	MAX; MYC (directAnnotation).
CDK17	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CDK17	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."