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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CDK1

Summary for CDK1

Gene information	Gene symbol	CDK1
	Ensembl ID	ENSG00000170312
	Entrez ID	983
	Gene name	cyclin dependent kinase 1
	Synonyms	CDC2\|CDC28A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CDK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.496879	1.86e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.413531	6.97e-28
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.320856	9.74e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.352133	3.87e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.630887	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.388343	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.599523	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.455633	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.464933	7.16e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.393223	1.09e-06
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.555111	1.12e-12
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.500704	2.16e-13
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.325732	0.00e+00

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Expression of CDK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CDK1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CDK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK1	hsa-miR-5011-5p	96.3498	NM_001786
CDK1	hsa-miR-3913-3p	94.8117	NM_001786
CDK1	hsa-miR-4760-3p	93.9784	NM_001786
CDK1	hsa-miR-6130	93.1552	NM_001170406
CDK1	hsa-miR-4510	93.1552	NM_001170406
CDK1	hsa-miR-6127	93.1552	NM_001170406
CDK1	hsa-miR-6133	93.1552	NM_001170406
CDK1	hsa-miR-6129	93.1552	NM_001170406
CDK1	hsa-miR-7-1-3p	91.305	NM_001786
CDK1	hsa-miR-7-2-3p	91.305	NM_001786
CDK1	hsa-miR-195-3p	91.0285	NM_001786
CDK1	hsa-miR-16-2-3p	91.0285	NM_001786
CDK1	hsa-miR-3618	90.5422	NM_001170406
CDK1	hsa-miR-6083	90.4753	NM_001170406
CDK1	hsa-miR-4696	90.203	NM_001170406
CDK1	hsa-miR-362-3p	88.887	NM_001170406
CDK1	hsa-miR-329-3p	88.887	NM_001170406
CDK1	hsa-miR-496	88.1725	NM_001170406
CDK1	hsa-miR-3941	87.7373	NM_001170406
CDK1	hsa-miR-188-3p	87.6315	NM_001170406
CDK1	hsa-miR-4698	86.7904	NM_001170406
CDK1	hsa-miR-802	86.7599	NM_001786
CDK1	hsa-miR-2114-5p	85.9774	NM_001170406
CDK1	hsa-miR-3911	85.9708	NM_001170406
CDK1	hsa-miR-208b-5p	85.9209	NM_001786
CDK1	hsa-miR-208a-5p	85.9209	NM_001786
CDK1	hsa-miR-649	85.0388	NM_001170406
CDK1	hsa-miR-5009-3p	84.8918	NM_001786
CDK1	hsa-miR-6762-3p	83.4748	NM_001786
CDK1	hsa-miR-4666a-5p	82.3048	NM_001170406
CDK1	hsa-miR-186-3p	81.3116	NM_001786
CDK1	hsa-miR-1267	81.0257	NM_001786
CDK1	hsa-miR-3163	80.7095	NM_001170406

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Motifs and transcription factors (TFs) regulating CDK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDK1	transfac_pro__M04826	EP300 (directAnnotation).
CDK1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CDK1	metacluster_102.2	ZBED1 (directAnnotation).
CDK1	transfac_public__M00209	NFYA; NFYB; NFYC (directAnnotation).
CDK1	transfac_pro__M06660	ZNF670 (directAnnotation).
CDK1	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
CDK1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CDK1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
CDK1	transfac_pro__M05711	ZNF37A (directAnnotation).
CDK1	transfac_pro__M06071	ZNF814 (directAnnotation).
CDK1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CDK1	transfac_pro__M06432	ZNF571 (directAnnotation).
CDK1	transfac_pro__M06487	ZNF695 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CDK1	"Alsterpaullone"	DB04014	small molecule
CDK1	"Alvocidib"	DB03496	small molecule
CDK1	"AT-7519"	DB08142	small molecule
CDK1	"Avotaciclib"	DB16652	small molecule
CDK1	"Fostamatinib"	DB12010	small molecule
CDK1	"Hymenialdisine"	DB02950	small molecule
CDK1	"Indirubin-3'-monoxime"	DB02052	small molecule
CDK1	"Olomoucine"	DB02116	small molecule
CDK1	"Seliciclib"	DB06195	small molecule
CDK1	"SU9516"	DB03428	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."