Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDC42EP3

Summary for CDC42EP3

Gene information	Gene symbol	CDC42EP3
	Ensembl ID	ENSG00000163171
	Entrez ID	10602
	Gene name	CDC42 effector protein 3
	Synonyms	BORG2\|CEP3\|UB1
	Gene type	protein_coding
	UniProtAcc	Q9UKI2

Top

Dataset with differentially expressed gene: CDC42EP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.60482	1.86e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.335265	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.271947	1.06e-06
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.285734	9.02e-38
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.263148	3.18e-22
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.611446	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.429355	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.940076	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.501544	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.326342	4.82e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.680157	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	1.36027	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.386026	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.328848	0.00e+00

Top

Expression of CDC42EP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CDC42EP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CDC42EP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDC42EP3	hsa-miR-450b-5p	99.9219	NM_001270436
CDC42EP3	hsa-miR-1245b-3p	97.429	NM_006449
CDC42EP3	hsa-miR-9983-3p	96.9717	NM_001270436
CDC42EP3	hsa-miR-3680-3p	96.8175	NM_001270436
CDC42EP3	hsa-miR-507	96.8175	NM_001270436
CDC42EP3	hsa-miR-129-5p	95.7073	NM_001270436
CDC42EP3	hsa-miR-1277-5p	95.5511	NM_006449
CDC42EP3	hsa-miR-557	95.3767	NM_001270436
CDC42EP3	hsa-miR-6507-5p	91.2806	NM_001270436
CDC42EP3	hsa-miR-5683	88.7578	NM_006449
CDC42EP3	hsa-miR-548c-3p	88.5081	NM_001270436
CDC42EP3	hsa-miR-8066	88.133	NM_001270436
CDC42EP3	hsa-miR-651-3p	87.9194	NM_006449
CDC42EP3	hsa-miR-27b-3p	87.7755	NM_006449
CDC42EP3	hsa-miR-9985	87.7755	NM_006449
CDC42EP3	hsa-miR-27a-3p	87.7755	NM_006449
CDC42EP3	hsa-miR-4698	86.7195	NM_006449
CDC42EP3	hsa-miR-4266	86.4612	NM_006449
CDC42EP3	hsa-miR-1283	85.5065	NM_006449
CDC42EP3	hsa-miR-4511	85.4873	NM_006449
CDC42EP3	hsa-miR-140-3p	84.0077	NM_006449
CDC42EP3	hsa-miR-552-5p	83.6713	NM_006449
CDC42EP3	hsa-miR-499a-3p	83.487	NM_006449
CDC42EP3	hsa-miR-499b-3p	83.487	NM_006449
CDC42EP3	hsa-miR-200a-3p	82.9389	NM_001270436
CDC42EP3	hsa-miR-141-3p	82.9389	NM_001270436
CDC42EP3	hsa-miR-582-5p	82.6835	NM_006449
CDC42EP3	hsa-miR-3662	82.2088	NM_001270436
CDC42EP3	hsa-miR-5007-5p	81.4663	NM_006449
CDC42EP3	hsa-miR-3974	80.6507	NM_006449
CDC42EP3	hsa-miR-5692b	80.3774	NM_006449
CDC42EP3	hsa-miR-5692c	80.3774	NM_006449

Page: 1

Top

Motifs and transcription factors (TFs) regulating CDC42EP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDC42EP3	cisbp__M00968	MTF2 (directAnnotation).
CDC42EP3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CDC42EP3	cisbp__M00341	PAX6 (directAnnotation).
CDC42EP3	metacluster_198.3	ZFP64 (directAnnotation).
CDC42EP3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CDC42EP3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CDC42EP3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CDC42EP3	cisbp__M00788	ZFY (inferredBy_Orthology).
CDC42EP3	metacluster_175.1	ZNF283 (directAnnotation).
CDC42EP3	hdpi__ZNF304	ZNF304 (directAnnotation).
CDC42EP3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CDC42EP3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CDC42EP3	transfac_pro__M01199	TRIM28 (directAnnotation).
CDC42EP3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CDC42EP3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CDC42EP3	transfac_pro__M03806	ZBTB7C (directAnnotation).
CDC42EP3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CDC42EP3	jaspar__MA1509.1	IRF6 (directAnnotation).
CDC42EP3	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
CDC42EP3	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
CDC42EP3	tfdimers__MD00476	BACH1; BACH2; FOXG1; FOXO1; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2L1; NFE2L2; NFE2L3 (directAnnotation).
CDC42EP3	tfdimers__MD00535	FOXG1; FOXO1; TFAP4 (directAnnotation).
CDC42EP3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CDC42EP3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CDC42EP3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CDC42EP3	jaspar__MA1721.1	ZNF93 (directAnnotation).
CDC42EP3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CDC42EP3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CDC42EP3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CDC42EP3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CDC42EP3	transfac_pro__M01253	CNOT3 (directAnnotation).
CDC42EP3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CDC42EP3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CDC42EP3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CDC42EP3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CDC42EP3	jaspar__MA0748.2	YY2 (directAnnotation).
CDC42EP3	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CDC42EP3	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CDC42EP3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CDC42EP3	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
CDC42EP3	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
CDC42EP3	transfac_pro__M07310	SP5 (directAnnotation).
CDC42EP3	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CDC42EP3	transfac_pro__M00938	E2F1 (directAnnotation).
CDC42EP3	transfac_pro__M04817	ZBTB33 (directAnnotation).
CDC42EP3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CDC42EP3	transfac_pro__M12697	ZNF142 (directAnnotation).
CDC42EP3	tfdimers__MD00364	WT1 (directAnnotation).
CDC42EP3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CDC42EP3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."