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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD48

Summary for CD48

Gene information	Gene symbol	CD48
	Ensembl ID	ENSG00000117091
	Entrez ID	962
	Gene name	CD48 molecule
	Synonyms	BCM1\|BLAST\|hCD48\|mCD48\|SLAMF2
	Gene type	protein_coding
	UniProtAcc	P09326

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Dataset with differentially expressed gene: CD48

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.289779	6.96e-12
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.345573	1.66e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.37067	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.254604	4.29e-02
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	0.351895	9.24e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.762501	6.33e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.276052	3.65e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.257961	9.81e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.340714	6.44e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.283346	3.12e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.616224	9.30e-21
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Malignant cells	-0.276177	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.761545	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	CD4+ T cells	-0.265979	1.48e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.62158	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.00736	7.07e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.325882	3.03e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.574543	7.36e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.366413	5.62e-08
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.569128	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	NK cells	-0.41016	1.48e-33
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	-0.394193	3.22e-44
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	B cells	-0.294288	6.45e-13

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Expression of CD48 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD48

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CD48	Malignant cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Malignant cells	NK cells	GSE161801_IMiD	post	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	NK cells	GSE161801_IMiD	pre	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Malignant cells	NK cells	GSE161801_IMiD	pre	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	NK cells	GSE161801_IMiD	pre	resistant
CD48	Malignant cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Malignant cells	NK cells	GSE161801_PI	post	resistant
CD48	B cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	NK cells	GSE169246_PacAteTissue	post	resistant
CD48	B cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	NK cells	GSE169246_PacAteTissue	post	sensitive
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	NK cells	GSE169246_PacAteTissue	post	sensitive
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	Mono/Macro	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	Mono/Macro	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Malignant cells	Mono/Macro	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	CD8+ T cells	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	Mono/Macro	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	NK cells	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	NK cells	Mono/Macro	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	cDCs	Mono/Macro	GSE189460	pre	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	NK cells	GSE189460	pre	sensitive
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	cDCs	GSE189460	pre	sensitive
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	NK cells	GSE199333	post	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	NK cells	GSE199333	post	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	NK cells	GSE199333	post	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	NK cells	Malignant cells	GSE199333	post	resistant
CD48	NK cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	NK cells	NK cells	GSE199333	post	resistant
CD48	B cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	Malignant cells	GSE199333	post	resistant
CD48	B cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	NK cells	GSE199333	post	resistant
CD48	CD8+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	Malignant cells	GSE199333	post	resistant
CD48	CD8+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	NK cells	GSE199333	post	resistant
CD48	CD8+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	Malignant cells	GSE199333	pre	resistant
CD48	CD8+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	NK cells	GSE199333	pre	resistant
CD48	CD4+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	Malignant cells	GSE199333	pre	resistant
CD48	CD4+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	NK cells	GSE199333	pre	resistant
CD48	CD8+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD8+ T cells	NK cells	GSE199333	pre	sensitive
CD48	CD4+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	NK cells	GSE199333	pre	sensitive
CD48	B cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	NK cells	GSE207422_Sin	post	resistant
CD48	B cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	B cells	NK cells	GSE207422_Sin	post	sensitive
CD48	pDCs	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	pDCs	NK cells	GSE207422_Sin	post	sensitive
CD48	CD4+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	NK cells	GSE207422_Tor	post	resistant
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	NK cells	GSE207422_Tor	post	resistant
CD48	CD4+ T cells	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	CD4+ T cells	NK cells	GSE207422_Tor	post	sensitive
CD48	Mono/Macro	CPI-SS056FF4363	CD48_CD244	CD48	CD244	False	Mono/Macro	NK cells	GSE207422_Tor	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD48

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD48	hsa-miR-3163	91.6727	NM_001778
CD48	hsa-miR-33a-3p	89.586	NM_001778
CD48	hsa-miR-6756-5p	89.3052	NM_001778
CD48	hsa-miR-6766-5p	89.3052	NM_001778
CD48	hsa-miR-4668-5p	80.0085	NM_001778

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Motifs and transcription factors (TFs) regulating CD48

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD48	metacluster_26.3	ZNF232 (directAnnotation).
CD48	transfac_pro__M06301	ZNF404 (directAnnotation).
CD48	tfdimers__MD00056	EP300; ZEB1 (directAnnotation).
CD48	transfac_pro__M06398	ZNF761 (directAnnotation).
CD48	transfac_pro__M06795	ZNF780B (directAnnotation).
CD48	transfac_pro__M06013	ZFP69B (directAnnotation).
CD48	transfac_pro__M06759	ZNF646 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."