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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CD38

Summary for CD38

Gene information	Gene symbol	CD38
	Ensembl ID	ENSG00000004468
	Entrez ID	952
	Gene name	CD38 molecule
	Synonyms	cADPR1
	Gene type	protein_coding
	UniProtAcc	P28907

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Dataset with differentially expressed gene: CD38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.363	1.21e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.5575	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	-0.319316	3.27e-33
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	-0.277109	7.44e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.751685	3.23e-08
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.382973	1.96e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.349704	5.94e-41
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.303011	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.278518	3.64e-13
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.432024	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.295434	6.47e-18
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.781032	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	-0.647676	6.22e-12
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.544234	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.989816	0.00e+00

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Expression of CD38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD38	hsa-miR-6835-3p	96.8689	NM_001775
CD38	hsa-miR-8075	93.0538	NM_001775
CD38	hsa-let-7b-3p	92.6879	NM_001775
CD38	hsa-let-7a-3p	92.6879	NM_001775
CD38	hsa-let-7f-1-3p	92.6879	NM_001775
CD38	hsa-miR-98-3p	92.6879	NM_001775
CD38	hsa-miR-7159-3p	92.0107	NM_001775
CD38	hsa-miR-4666a-3p	91.9744	NM_001775
CD38	hsa-miR-6867-5p	89.1355	NM_001775
CD38	hsa-miR-6077	87.2467	NM_001775
CD38	hsa-miR-664b-3p	86.2159	NM_001775
CD38	hsa-miR-579-3p	86.2159	NM_001775
CD38	hsa-miR-6805-3p	86.0714	NM_001775
CD38	hsa-miR-5691	86.0714	NM_001775
CD38	hsa-miR-548x-3p	85.0802	NM_001775
CD38	hsa-miR-548aj-3p	85.0802	NM_001775
CD38	hsa-miR-3202	84.1837	NM_001775
CD38	hsa-miR-3173-3p	83.3395	NM_001775
CD38	hsa-miR-576-5p	83.0003	NM_001775
CD38	hsa-miR-500a-5p	82.514	NM_001775
CD38	hsa-miR-8068	82.1792	NM_001775
CD38	hsa-miR-513c-3p	81.5598	NM_001775
CD38	hsa-miR-513a-3p	81.5598	NM_001775
CD38	hsa-miR-548am-3p	81.4104	NM_001775
CD38	hsa-miR-548ah-3p	81.4104	NM_001775
CD38	hsa-miR-548j-3p	81.4104	NM_001775
CD38	hsa-miR-548ae-3p	81.4104	NM_001775
CD38	hsa-miR-548aq-3p	81.4104	NM_001775
CD38	hsa-miR-4728-3p	80.9527	NM_001775
CD38	hsa-miR-150-5p	80.9159	NM_001775
CD38	hsa-miR-1277-5p	80.1857	NM_001775

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Motifs and transcription factors (TFs) regulating CD38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD38	tfdimers__MD00581	ATF5; NKX3-2 (directAnnotation).
CD38	taipale__Tp53_DBD_ACAWGTCNNNNRACAWGT_repr	TP53 (inferredBy_Orthology).
CD38	taipale_tf_pairs__TEAD4_FIGLA_GGAATKNNCASSTG_CAP	FIGLA; TEAD4 (directAnnotation).
CD38	hdpi__SOX14	SOX14 (directAnnotation).
CD38	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
CD38	hdpi__KLF4	KLF4 (directAnnotation).
CD38	taipale_tf_pairs__PITX1_FIGLA_TAATCCNNNNCASSTG_CAP_repr	FIGLA; PITX1 (directAnnotation).
CD38	transfac_pro__M06439	ZNF250 (inferredBy_Orthology).
CD38	tfdimers__MD00460	MYOG (directAnnotation).
CD38	transfac_pro__M05472	ZBTB41 (directAnnotation).
CD38	transfac_pro__M06468	ZNF808 (directAnnotation).
CD38	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CD38	"Daratumumab"	DB09331	biotech
CD38	"Isatuximab"	DB14811	biotech
CD38	"Mezagitamab"	DB16370	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."