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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD1C

Summary for CD1C

Gene information	Gene symbol	CD1C
	Ensembl ID	ENSG00000158481
	Entrez ID	911
	Gene name	CD1c molecule
	Synonyms	CD1
	Gene type	protein_coding
	UniProtAcc	P29017

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Dataset with differentially expressed gene: CD1C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	cDCs	0.499359	1.81e-04
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.604959	1.08e-32
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	cDCs	-0.93469	3.61e-04

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Expression of CD1C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD1C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD1C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD1C	hsa-miR-570-3p	94.0293	NM_001765
CD1C	hsa-miR-4428	90.6193	NM_001765
CD1C	hsa-miR-27a-5p	87.8237	NM_001765
CD1C	hsa-miR-33a-3p	87.3111	NM_001765
CD1C	hsa-miR-5194	87.3097	NM_001765
CD1C	hsa-miR-548l	84.8978	NM_001765
CD1C	hsa-miR-4282	84.1481	NM_001765
CD1C	hsa-miR-889-3p	83.3707	NM_001765
CD1C	hsa-miR-6829-3p	82.5684	NM_001765
CD1C	hsa-miR-6791-3p	82.5684	NM_001765
CD1C	hsa-miR-1914-3p	82.3687	NM_001765
CD1C	hsa-miR-6738-5p	82.3687	NM_001765
CD1C	hsa-miR-4747-5p	81.9944	NM_001765
CD1C	hsa-miR-5196-5p	81.9944	NM_001765
CD1C	hsa-miR-6870-5p	81.8585	NM_001765

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Motifs and transcription factors (TFs) regulating CD1C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD1C	metacluster_44.18	NKX3-2 (directAnnotation).
CD1C	transfac_pro__M05755	ZNF718 (directAnnotation).
CD1C	taipale_tf_pairs__CLOCK_TBX3_GGTGTGNNNNNCACGTG_CAP_repr	CLOCK; TBX3 (directAnnotation).
CD1C	cisbp__M01752	USF2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."