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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD164

Summary for CD164

Gene information	Gene symbol	CD164
	Ensembl ID	ENSG00000135535
	Entrez ID	8763
	Gene name	CD164 molecule
	Synonyms	DFNA66\|MGC-24\|MUC-24
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CD164

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.298844	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.651047	2.93e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.30296	2.49e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.308058	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.438427	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.300713	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	1.15296	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.270779	1.10e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.308954	4.41e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.394851	3.59e-24
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.967791	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.337893	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.494968	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.634521	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.409071	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.329175	0.00e+00

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Expression of CD164 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD164

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD164

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD164	hsa-miR-506-3p	98.9996	NM_001142401
CD164	hsa-miR-124-3p	98.9996	NM_001142401
CD164	hsa-miR-1294	98.599	NM_001142401
CD164	hsa-miR-9986	98.599	NM_001142401
CD164	hsa-miR-95-5p	98.2429	NM_001142403
CD164	hsa-miR-4782-3p	97.5043	NM_001142403
CD164	hsa-miR-219a-5p	97.5043	NM_001142403
CD164	hsa-miR-6766-3p	97.5043	NM_001142403
CD164	hsa-miR-3163	97.0422	NM_001142401
CD164	hsa-miR-548ai	96.7806	NM_001142401
CD164	hsa-miR-548ag	96.7806	NM_001142401
CD164	hsa-miR-570-5p	96.7806	NM_001142401
CD164	hsa-miR-548ba	96.7806	NM_001142401
CD164	hsa-miR-580-5p	96.2827	NM_001142401
CD164	hsa-miR-96-5p	96.1869	NM_001142401
CD164	hsa-miR-6839-5p	94.0879	NM_001142401
CD164	hsa-miR-378j	93.905	NM_001142403
CD164	hsa-miR-6818-3p	93.7067	NM_001142403
CD164	hsa-miR-548as-3p	93.4536	NM_001142403
CD164	hsa-miR-4316	93.319	NM_001142401
CD164	hsa-miR-12133	93.3146	NM_001142401
CD164	hsa-miR-1271-5p	93.3146	NM_001142401
CD164	hsa-miR-203b-3p	92.9068	NM_001142401
CD164	hsa-miR-298	92.4747	NM_001142401
CD164	hsa-miR-4500	92.2908	NM_001142401
CD164	hsa-miR-3121-3p	92.1321	NM_001142401
CD164	hsa-miR-6783-5p	92.0714	NM_001142403
CD164	hsa-miR-6128	92.0598	NM_001142401
CD164	hsa-miR-4778-5p	91.678	NM_001142401
CD164	hsa-miR-5582-3p	91.4812	NM_001142403
CD164	hsa-miR-4648	91.3937	NM_001142401
CD164	hsa-miR-6824-5p	90.9619	NM_001142403
CD164	hsa-miR-1245b-3p	90.8495	NM_001142403
CD164	hsa-miR-570-3p	90.774	NM_001142403
CD164	hsa-miR-4261	90.6038	NM_001142403
CD164	hsa-miR-3668	89.6761	NM_001142401
CD164	hsa-miR-1290	89.2873	NM_001142401
CD164	hsa-miR-6758-3p	89.024	NM_001142403
CD164	hsa-miR-3714	88.9424	NM_001142401
CD164	hsa-miR-3910	88.9424	NM_001142401
CD164	hsa-miR-7106-5p	88.9185	NM_001142403
CD164	hsa-miR-147b-5p	88.7962	NM_001142403
CD164	hsa-miR-182-5p	88.7056	NM_001142401
CD164	hsa-miR-5001-3p	88.5493	NM_001142403
CD164	hsa-let-7a-5p	88.2655	NM_001142401
CD164	hsa-let-7f-5p	88.2655	NM_001142401
CD164	hsa-miR-98-5p	88.2655	NM_001142401
CD164	hsa-let-7e-5p	88.2655	NM_001142401
CD164	hsa-let-7g-5p	88.2655	NM_001142401
CD164	hsa-let-7i-5p	88.2655	NM_001142401

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Motifs and transcription factors (TFs) regulating CD164

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD164	tfdimers__MD00391	KLF4 (directAnnotation).
CD164	transfac_pro__M01973	PLAG1 (directAnnotation).
CD164	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
CD164	transfac_public__M00491	PATZ1 (directAnnotation).
CD164	transfac_pro__M07397	ZNF148 (directAnnotation).
CD164	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
CD164	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CD164	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
CD164	metacluster_172.6	CHD2; E2F1 (directAnnotation).
CD164	tfdimers__MD00438	E2F1; NKX3-2 (directAnnotation).
CD164	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).
CD164	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
CD164	cisbp__M00767	ZSCAN10 (inferredBy_Orthology).
CD164	transfac_pro__M06723	ZNF492 (directAnnotation).
CD164	transfac_public__M00237	AHR; ARNT (directAnnotation).
CD164	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CD164	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CD164	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CD164	transfac_pro__M07310	SP5 (directAnnotation).
CD164	cisbp__M07938	E2F1 (directAnnotation).
CD164	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CD164	metacluster_45.4	E2F2 (directAnnotation).
CD164	metacluster_175.1	ZNF283 (directAnnotation).
CD164	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CD164	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
CD164	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CD164	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
CD164	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
CD164	tfdimers__MD00364	WT1 (directAnnotation).
CD164	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CD164	transfac_pro__M05463	ZIM2 (directAnnotation).
CD164	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CD164	metacluster_141.4	GLIS2 (directAnnotation).
CD164	transfac_pro__M06331	ZNF343 (directAnnotation).
CD164	transfac_pro__M01783	SP2 (directAnnotation).
CD164	metacluster_135.11	NR2C2 (directAnnotation).
CD164	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
CD164	kznf__ZNF343_Imbeault2017_RP_RCADE	ZNF343 (directAnnotation).
CD164	transfac_pro__M05364	ZNF146 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."