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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CCND1

Summary for CCND1

Gene information	Gene symbol	CCND1
	Ensembl ID	ENSG00000110092
	Entrez ID	595
	Gene name	cyclin D1
	Synonyms	BCL1\|D11S287E\|PRAD1\|U21B31
	Gene type	protein_coding
	UniProtAcc	P24385

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Dataset with differentially expressed gene: CCND1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.857848	1.83e-08
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.599395	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.753783	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.386016	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.421806	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	1.02681	1.39e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	1.60349	9.77e-29
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.22138	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.678379	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.601775	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.45441	1.05e-31
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	1.08012	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.26781	1.07e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-2.04514	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.401287	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-1.29196	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.540435	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.52664	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.89883	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.925778	0.00e+00

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Expression of CCND1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCND1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CCND1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CCND1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCND1	hsa-miR-7110-3p	98.7121	NM_053056
CCND1	hsa-miR-4753-3p	98.5899	NM_053056
CCND1	hsa-miR-6867-5p	97.9781	NM_053056
CCND1	hsa-miR-106b-5p	97.3777	NM_053056
CCND1	hsa-miR-20a-5p	97.3777	NM_053056
CCND1	hsa-miR-17-5p	96.9937	NM_053056
CCND1	hsa-miR-106a-5p	96.9937	NM_053056
CCND1	hsa-miR-20b-5p	96.9937	NM_053056
CCND1	hsa-miR-93-5p	96.9937	NM_053056
CCND1	hsa-miR-519d-3p	96.9937	NM_053056
CCND1	hsa-miR-1283	96.511	NM_053056
CCND1	hsa-miR-526b-3p	95.4957	NM_053056
CCND1	hsa-miR-503-5p	94.6131	NM_053056
CCND1	hsa-miR-130a-5p	94.5573	NM_053056
CCND1	hsa-miR-195-5p	93.8013	NM_053056
CCND1	hsa-miR-15a-5p	92.5726	NM_053056
CCND1	hsa-miR-16-5p	92.5726	NM_053056
CCND1	hsa-miR-15b-5p	92.5726	NM_053056
CCND1	hsa-miR-202-3p	91.2815	NM_053056
CCND1	hsa-miR-9851-3p	90.6423	NM_053056
CCND1	hsa-miR-4524a-5p	90.6117	NM_053056
CCND1	hsa-miR-4524b-5p	90.6117	NM_053056
CCND1	hsa-miR-548aj-3p	90.5324	NM_053056
CCND1	hsa-miR-548x-3p	90.5324	NM_053056
CCND1	hsa-miR-424-5p	90.3456	NM_053056
CCND1	hsa-miR-497-5p	90.3456	NM_053056
CCND1	hsa-miR-6838-5p	90.3456	NM_053056
CCND1	hsa-miR-19a-3p	90.0317	NM_053056
CCND1	hsa-miR-19b-3p	90.0317	NM_053056
CCND1	hsa-miR-5088-3p	89.7175	NM_053056
CCND1	hsa-miR-4307	89.46	NM_053056
CCND1	hsa-miR-593-5p	89.447	NM_053056
CCND1	hsa-miR-374b-5p	89.3489	NM_053056
CCND1	hsa-miR-122b-5p	89.2429	NM_053056
CCND1	hsa-miR-548j-3p	89.0974	NM_053056
CCND1	hsa-miR-548am-3p	89.0974	NM_053056
CCND1	hsa-miR-548ah-3p	89.0974	NM_053056
CCND1	hsa-miR-548ae-3p	89.0974	NM_053056
CCND1	hsa-miR-548aq-3p	89.0974	NM_053056
CCND1	hsa-miR-8073	88.5911	NM_053056
CCND1	hsa-miR-221-5p	88.5911	NM_053056
CCND1	hsa-miR-374a-5p	87.6063	NM_053056
CCND1	hsa-miR-193b-3p	86.9836	NM_053056
CCND1	hsa-miR-193a-3p	86.9836	NM_053056
CCND1	hsa-miR-5006-3p	86.2927	NM_053056
CCND1	hsa-miR-4755-5p	86.2927	NM_053056
CCND1	hsa-miR-548ah-5p	84.7557	NM_053056
CCND1	hsa-miR-3609	84.7557	NM_053056
CCND1	hsa-miR-511-5p	83.9204	NM_053056
CCND1	hsa-miR-1277-5p	82.8195	NM_053056

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Motifs and transcription factors (TFs) regulating CCND1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCND1	tfdimers__MD00192	CHURC1 (directAnnotation).
CCND1	transfac_pro__M05550	SNAPC4 (inferredBy_Orthology).
CCND1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CCND1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CCND1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CCND1	cisbp__M08198	ELF1 (directAnnotation).
CCND1	jaspar__MA1957.1	ELK1 (directAnnotation).
CCND1	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
CCND1	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
CCND1	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
CCND1	transfac_pro__M05770	ZNF77 (directAnnotation).
CCND1	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
CCND1	transfac_pro__M06602	ZNF669 (directAnnotation).
CCND1	transfac_pro__M09726	GATAD2A (directAnnotation).
CCND1	tfdimers__MD00490	CDX2; SOX2 (directAnnotation).
CCND1	tfdimers__MD00516	SOX10 (directAnnotation).
CCND1	hdpi__NFIX	NFIX (directAnnotation).
CCND1	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
CCND1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
CCND1	metacluster_74.6	HNF1A (directAnnotation).
CCND1	taipale_tf_pairs__MYBL1_MAX_YAACGGNNNNNNNNNNCACGTG_CAP_repr	MAX; MYBL1 (directAnnotation).
CCND1	metacluster_81.7	CREB1 (directAnnotation).
CCND1	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).
CCND1	metacluster_26.7	MYNN; MYNN (directAnnotation).
CCND1	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
CCND1	transfac_pro__M01835	KLF4 (directAnnotation).
CCND1	swissregulon__hs__MTA3	MTA3 (directAnnotation).
CCND1	transfac_pro__M07270	TEAD4 (directAnnotation).
CCND1	metacluster_74.19	HNF1A (inferredBy_Orthology).
CCND1	metacluster_74.23	HNF1B (inferredBy_Orthology).
CCND1	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
CCND1	metacluster_74.5	HNF1B (directAnnotation).
CCND1	transfac_pro__M06181	ZNF165 (directAnnotation).
CCND1	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
CCND1	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
CCND1	tfdimers__MD00024	FOXO1; PAX4 (directAnnotation).
CCND1	metacluster_26.4	CDC5L; CDC5L; CDC5L; ZNF580; ZNF580 (directAnnotation).
CCND1	tfdimers__MD00561	CRX (directAnnotation).
CCND1	transfac_pro__M04748	GABPA (directAnnotation).
CCND1	transfac_public__M00041	ATF2; JUN (directAnnotation).
CCND1	metacluster_161.3	LHX9 (directAnnotation).
CCND1	transfac_pro__M02089	E2F3 (directAnnotation).
CCND1	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CCND1	transfac_pro__M07329	SP7 (directAnnotation).
CCND1	transfac_pro__M07397	ZNF148 (directAnnotation).
CCND1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CCND1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CCND1	transfac_pro__M07436	WT1 (directAnnotation).
CCND1	transfac_pro__M01837	KLF11 (directAnnotation).
CCND1	swissregulon__hs__KLF6	KLF6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CCND1	"Acetylsalicylic acid"	DB00945	small molecule
CCND1	"Arsenic trioxide"	DB01169	small molecule
CCND1	"Bryostatin 1"	DB11752	small molecule
CCND1	"Encorafenib"	DB11718	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."