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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC186

Summary for CCDC186

Gene information	Gene symbol	CCDC186
	Ensembl ID	ENSG00000165813
	Entrez ID	55088
	Gene name	coiled-coil domain containing 186
	Synonyms	C10orf118\|CCCP-1\|FLJ10188\|FLJ35301\|golgin104
	Gene type	protein_coding
	UniProtAcc	Q7Z3E2

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Dataset with differentially expressed gene: CCDC186

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.712409	2.42e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.324626	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.448976	0.00e+00

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Expression of CCDC186 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC186

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC186

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC186	hsa-miR-3646	99.611	NM_153249
CCDC186	hsa-miR-5692a	99.3587	NM_001321829
CCDC186	hsa-miR-4282	98.986	NM_018017
CCDC186	hsa-miR-5011-5p	98.1406	NM_018017
CCDC186	hsa-miR-5582-3p	97.8085	NM_018017
CCDC186	hsa-miR-548c-3p	97.8047	NM_001321829
CCDC186	hsa-miR-302a-5p	96.8446	NM_001321829
CCDC186	hsa-miR-548ar-3p	96.465	NM_018017
CCDC186	hsa-miR-1279	96.0709	NM_018017
CCDC186	hsa-miR-522-3p	95.6883	NM_153249
CCDC186	hsa-miR-548bc	95.5089	NM_018017
CCDC186	hsa-miR-548a-3p	95.5089	NM_018017
CCDC186	hsa-miR-548f-3p	95.5089	NM_018017
CCDC186	hsa-miR-548e-3p	95.5089	NM_018017
CCDC186	hsa-miR-548az-3p	95.5089	NM_018017
CCDC186	hsa-miR-224-3p	94.6569	NM_153249
CCDC186	hsa-miR-5004-5p	94.4676	NM_153249
CCDC186	hsa-miR-4422	94.1489	NM_018017
CCDC186	hsa-miR-302c-5p	94.0663	NM_153249
CCDC186	hsa-miR-590-3p	93.7537	NM_153249
CCDC186	hsa-miR-338-5p	93.2631	NM_018017
CCDC186	hsa-miR-1250-3p	93.1536	NM_018017
CCDC186	hsa-miR-23b-3p	92.9724	NM_153249
CCDC186	hsa-miR-23a-3p	92.9724	NM_153249
CCDC186	hsa-miR-23c	92.9724	NM_153249
CCDC186	hsa-miR-4694-5p	92.9138	NM_018017
CCDC186	hsa-miR-3658	92.8921	NM_153249
CCDC186	hsa-miR-573	92.2264	NM_001321829
CCDC186	hsa-miR-126-5p	92.1801	NM_153249
CCDC186	hsa-miR-3616-5p	91.8993	NM_001321829
CCDC186	hsa-miR-8485	91.7341	NM_018017
CCDC186	hsa-miR-4666a-3p	91.6123	NM_001321829
CCDC186	hsa-miR-6835-5p	91.4473	NM_153249
CCDC186	hsa-miR-1185-1-3p	91.148	NM_018017
CCDC186	hsa-let-7f-2-3p	91.148	NM_018017
CCDC186	hsa-miR-1185-2-3p	91.148	NM_018017
CCDC186	hsa-miR-539-5p	91.003	NM_001321829
CCDC186	hsa-miR-122-5p	90.9487	NM_018017
CCDC186	hsa-let-7f-1-3p	90.7854	NM_001321829
CCDC186	hsa-let-7b-3p	90.7854	NM_001321829
CCDC186	hsa-miR-10527-5p	90.6021	NM_001321829
CCDC186	hsa-miR-513a-3p	90.5937	NM_018017
CCDC186	hsa-miR-513c-3p	90.5937	NM_018017
CCDC186	hsa-miR-4795-3p	90.5527	NM_153249
CCDC186	hsa-miR-30d-3p	90.4703	NM_018017
CCDC186	hsa-miR-30e-3p	90.4703	NM_018017
CCDC186	hsa-miR-30a-3p	90.4703	NM_018017
CCDC186	hsa-miR-6504-3p	90.1721	NM_153249
CCDC186	hsa-miR-10399-5p	90.1721	NM_153249
CCDC186	hsa-miR-4715-3p	90.0773	NM_001321829

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Motifs and transcription factors (TFs) regulating CCDC186

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC186	jaspar__MA0748.2	YY2 (directAnnotation).
CCDC186	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CCDC186	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CCDC186	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
CCDC186	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CCDC186	transfac_pro__M07310	SP5 (directAnnotation).
CCDC186	transfac_pro__M00938	E2F1 (directAnnotation).
CCDC186	transfac_pro__M04817	ZBTB33 (directAnnotation).
CCDC186	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CCDC186	transfac_pro__M12697	ZNF142 (directAnnotation).
CCDC186	tfdimers__MD00364	WT1 (directAnnotation).
CCDC186	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CCDC186	transfac_pro__M04916	TAF1 (directAnnotation).
CCDC186	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
CCDC186	transfac_pro__M01973	PLAG1 (directAnnotation).
CCDC186	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CCDC186	tfdimers__MD00483	ZBTB14 (directAnnotation).
CCDC186	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CCDC186	transfac_pro__M01303	SP1 (directAnnotation).
CCDC186	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
CCDC186	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
CCDC186	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
CCDC186	metacluster_144.13	HIC1; HIC1 (directAnnotation).
CCDC186	transfac_pro__M00514	ATF4 (directAnnotation).
CCDC186	transfac_pro__M00665	SP3 (directAnnotation).
CCDC186	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CCDC186	transfac_pro__M02898	SMAD3 (directAnnotation).
CCDC186	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
CCDC186	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CCDC186	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
CCDC186	transfac_pro__M07329	SP7 (directAnnotation).
CCDC186	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
CCDC186	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."