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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAPRIN1

Summary for CAPRIN1

Gene information	Gene symbol	CAPRIN1
	Ensembl ID	ENSG00000135387
	Entrez ID	4076
	Gene name	cell cycle associated protein 1
	Synonyms	caprin-1\|GPIAP1\|M11S1\|RNG105
	Gene type	protein_coding
	UniProtAcc	Q14444

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Dataset with differentially expressed gene: CAPRIN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.270792	8.25e-14
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.33825	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.263232	1.08e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.430115	1.71e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.36883	4.72e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.251905	1.14e-39
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.251886	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.397672	0.00e+00

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Expression of CAPRIN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAPRIN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAPRIN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAPRIN1	hsa-miR-448	98.3563	NM_005898
CAPRIN1	hsa-miR-4803	97.3628	NM_005898
CAPRIN1	hsa-miR-3620-3p	95.8504	NM_005898
CAPRIN1	hsa-miR-7159-5p	95.3326	NM_203364
CAPRIN1	hsa-miR-497-3p	94.997	NM_005898
CAPRIN1	hsa-miR-6849-3p	94.4759	NM_005898
CAPRIN1	hsa-miR-550a-3p	94.1572	NM_203364
CAPRIN1	hsa-miR-4738-3p	94.1268	NM_005898
CAPRIN1	hsa-miR-3148	93.5431	NM_005898
CAPRIN1	hsa-miR-3613-3p	93.5395	NM_203364
CAPRIN1	hsa-miR-4255	93.0193	NM_005898
CAPRIN1	hsa-miR-200c-5p	93.0111	NM_203364
CAPRIN1	hsa-miR-621	92.2127	NM_005898
CAPRIN1	hsa-miR-124-5p	91.6637	NM_005898
CAPRIN1	hsa-miR-4435	91.6087	NM_005898
CAPRIN1	hsa-miR-6838-3p	90.8949	NM_005898
CAPRIN1	hsa-miR-875-3p	90.7583	NM_005898
CAPRIN1	hsa-miR-548g-3p	90.5388	NM_203364
CAPRIN1	hsa-miR-6868-3p	90.2507	NM_005898
CAPRIN1	hsa-miR-3194-5p	89.6724	NM_005898
CAPRIN1	hsa-miR-5699-3p	89.3134	NM_005898
CAPRIN1	hsa-miR-34c-3p	88.938	NM_203364
CAPRIN1	hsa-miR-222-5p	88.9268	NM_203364
CAPRIN1	hsa-miR-5681a	88.8728	NM_005898
CAPRIN1	hsa-miR-4421	88.8607	NM_005898
CAPRIN1	hsa-miR-7-2-3p	88.8346	NM_005898
CAPRIN1	hsa-miR-7-1-3p	88.8346	NM_005898
CAPRIN1	hsa-miR-548l	88.412	NM_005898
CAPRIN1	hsa-miR-6885-3p	87.7745	NM_005898
CAPRIN1	hsa-miR-23c	87.7665	NM_005898
CAPRIN1	hsa-miR-23a-3p	87.7665	NM_005898
CAPRIN1	hsa-miR-23b-3p	87.7665	NM_005898
CAPRIN1	hsa-miR-5187-5p	87.656	NM_005898
CAPRIN1	hsa-miR-195-5p	87.6133	NM_005898
CAPRIN1	hsa-miR-15a-5p	87.6133	NM_005898
CAPRIN1	hsa-miR-15b-5p	87.6133	NM_005898
CAPRIN1	hsa-miR-16-5p	87.6133	NM_005898
CAPRIN1	hsa-miR-4490	87.2964	NM_005898
CAPRIN1	hsa-miR-6516-5p	87.1611	NM_005898
CAPRIN1	hsa-miR-8053	87.067	NM_005898
CAPRIN1	hsa-miR-6808-3p	86.8747	NM_005898
CAPRIN1	hsa-miR-7705	86.5034	NM_203364
CAPRIN1	hsa-miR-206	86.0776	NM_005898
CAPRIN1	hsa-miR-1-3p	86.0776	NM_005898
CAPRIN1	hsa-miR-5584-5p	86.0199	NM_005898
CAPRIN1	hsa-miR-889-3p	85.8472	NM_005898
CAPRIN1	hsa-miR-656-3p	85.6574	NM_005898
CAPRIN1	hsa-miR-558	85.6259	NM_005898
CAPRIN1	hsa-miR-6727-3p	85.6009	NM_203364
CAPRIN1	hsa-miR-320c	85.3978	NM_005898

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Motifs and transcription factors (TFs) regulating CAPRIN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAPRIN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CAPRIN1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CAPRIN1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CAPRIN1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CAPRIN1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CAPRIN1	transfac_pro__M00652	NRF1 (directAnnotation).
CAPRIN1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CAPRIN1	transfac_pro__M04866	HDAC2 (directAnnotation).
CAPRIN1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CAPRIN1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CAPRIN1	transfac_pro__M04748	GABPA (directAnnotation).
CAPRIN1	hdpi__TP73	TP73 (directAnnotation).
CAPRIN1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CAPRIN1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CAPRIN1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CAPRIN1	cisbp__M02645	ETS1 (directAnnotation).
CAPRIN1	transfac_pro__M01298	MECP2 (directAnnotation).
CAPRIN1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CAPRIN1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CAPRIN1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CAPRIN1	cisbp__M00249	WT1 (directAnnotation).
CAPRIN1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CAPRIN1	transfac_pro__M05432	ZSCAN18 (directAnnotation).
CAPRIN1	transfac_pro__M01122	ZNF219 (directAnnotation).
CAPRIN1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CAPRIN1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CAPRIN1	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
CAPRIN1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CAPRIN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CAPRIN1	metacluster_84.2	RARA (directAnnotation).
CAPRIN1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CAPRIN1	transfac_pro__M01253	CNOT3 (directAnnotation).
CAPRIN1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CAPRIN1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
CAPRIN1	jaspar__MA1721.1	ZNF93 (directAnnotation).
CAPRIN1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CAPRIN1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CAPRIN1	cisbp__M00341	PAX6 (directAnnotation).
CAPRIN1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CAPRIN1	transfac_pro__M01199	TRIM28 (directAnnotation).
CAPRIN1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
CAPRIN1	tfdimers__MD00391	KLF4 (directAnnotation).
CAPRIN1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
CAPRIN1	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
CAPRIN1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
CAPRIN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CAPRIN1	cisbp__M00968	MTF2 (directAnnotation).
CAPRIN1	transfac_pro__M01973	PLAG1 (directAnnotation).
CAPRIN1	transfac_pro__M12697	ZNF142 (directAnnotation).
CAPRIN1	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."