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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CAMK2D

Summary for CAMK2D

Gene information	Gene symbol	CAMK2D
	Ensembl ID	ENSG00000145349
	Entrez ID	817
	Gene name	calcium/calmodulin dependent protein kinase II delta
	Synonyms	CAMKD
	Gene type	protein_coding
	UniProtAcc	Q13557

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Dataset with differentially expressed gene: CAMK2D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.275592	1.52e-25
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.429893	3.36e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.261724	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.261098	3.42e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.304889	1.67e-14
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.31731	5.45e-18

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Expression of CAMK2D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAMK2D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAMK2D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAMK2D	hsa-miR-3925-5p	99.2057	NM_001321589
CAMK2D	hsa-miR-3919	98.3332	NM_001321587
CAMK2D	hsa-miR-4719	98.1804	NM_001321587
CAMK2D	hsa-miR-1277-5p	97.9608	NM_001321589
CAMK2D	hsa-miR-545-3p	96.9261	NM_001321589
CAMK2D	hsa-miR-4698	95.9174	NM_001321587
CAMK2D	hsa-miR-586	95.4618	NM_001321587
CAMK2D	hsa-miR-5696	94.7359	NM_001321592
CAMK2D	hsa-miR-7112-3p	94.2989	NM_001321587
CAMK2D	hsa-miR-1257	94.2895	NM_001321574
CAMK2D	hsa-miR-4755-5p	94.1807	NM_001321589
CAMK2D	hsa-miR-5006-3p	94.1807	NM_001321589
CAMK2D	hsa-miR-30b-5p	93.8015	NM_001321589
CAMK2D	hsa-miR-30d-5p	93.8015	NM_001321589
CAMK2D	hsa-miR-30e-5p	93.8015	NM_001321589
CAMK2D	hsa-miR-30a-5p	93.8015	NM_001321589
CAMK2D	hsa-miR-30c-5p	93.8015	NM_001321589
CAMK2D	hsa-miR-4775	93.3047	NM_001321592
CAMK2D	hsa-miR-590-3p	92.9889	NM_001321592
CAMK2D	hsa-miR-4533	92.2636	NM_001321589
CAMK2D	hsa-let-7c-3p	92.1411	NM_001321592
CAMK2D	hsa-miR-889-3p	91.82	NM_001321592
CAMK2D	hsa-miR-383-5p	91.169	NM_001321587
CAMK2D	hsa-miR-5093	90.9399	NM_001321592
CAMK2D	hsa-miR-1267	90.303	NM_001321574
CAMK2D	hsa-miR-548t-5p	90.1955	NM_001321589
CAMK2D	hsa-miR-548az-5p	90.1955	NM_001321589
CAMK2D	hsa-miR-6772-5p	89.7123	NM_172115
CAMK2D	hsa-miR-509-3-5p	88.777	NM_001321589
CAMK2D	hsa-miR-509-5p	88.777	NM_001321589
CAMK2D	hsa-miR-890	88.199	NM_001321587
CAMK2D	hsa-miR-2115-3p	88.0599	NM_001321589
CAMK2D	hsa-miR-4704-5p	88.0011	NM_001321592
CAMK2D	hsa-miR-4752	87.9795	NM_001321589
CAMK2D	hsa-miR-5195-3p	87.1598	NM_001321589
CAMK2D	hsa-miR-145-5p	87.1598	NM_001321589
CAMK2D	hsa-miR-4668-5p	87.0759	NM_001321587
CAMK2D	hsa-miR-548n	86.9051	NM_001321587
CAMK2D	hsa-miR-3667-5p	86.7353	NM_001321574
CAMK2D	hsa-miR-31-5p	86.7258	NM_001321589
CAMK2D	hsa-miR-4418	86.1246	NM_001321589
CAMK2D	hsa-miR-936	86.1046	NM_001321587
CAMK2D	hsa-miR-4470	85.9638	NM_001321587
CAMK2D	hsa-miR-1252-5p	85.7652	NM_001321589
CAMK2D	hsa-miR-6876-5p	85.2797	NM_001321589
CAMK2D	hsa-miR-4476	85.2797	NM_001321589
CAMK2D	hsa-miR-4709-3p	85.2783	NM_001321589
CAMK2D	hsa-miR-4272	85.2123	NM_001321592
CAMK2D	hsa-miR-2681-5p	85.1063	NM_001321587
CAMK2D	hsa-miR-1262	83.9562	NM_001321587

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Motifs and transcription factors (TFs) regulating CAMK2D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAMK2D	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
CAMK2D	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CAMK2D	transfac_pro__M02089	E2F3 (directAnnotation).
CAMK2D	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CAMK2D	transfac_pro__M02898	SMAD3 (directAnnotation).
CAMK2D	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CAMK2D	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CAMK2D	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CAMK2D	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CAMK2D	transfac_pro__M00430	E2F1 (directAnnotation).
CAMK2D	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CAMK2D	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CAMK2D	transfac_pro__M07329	SP7 (directAnnotation).
CAMK2D	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
CAMK2D	transfac_pro__M07397	ZNF148 (directAnnotation).
CAMK2D	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CAMK2D	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CAMK2D	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CAMK2D	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CAMK2D	transfac_pro__M07436	WT1 (directAnnotation).
CAMK2D	metacluster_3.14	WT1; WT1 (directAnnotation).
CAMK2D	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CAMK2D	transfac_pro__M01837	KLF11 (directAnnotation).
CAMK2D	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CAMK2D	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CAMK2D	swissregulon__hs__KLF6	KLF6 (directAnnotation).
CAMK2D	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CAMK2D	transfac_pro__M01175	ZBTB7B (directAnnotation).
CAMK2D	transfac_pro__M00716	ZBTB14 (directAnnotation).
CAMK2D	jaspar__MA1122.1	TFDP1 (directAnnotation).
CAMK2D	transfac_pro__M07297	MAZ (directAnnotation).
CAMK2D	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CAMK2D	metacluster_163.2	ZNF682 (directAnnotation).
CAMK2D	transfac_pro__M04916	TAF1 (directAnnotation).
CAMK2D	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
CAMK2D	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
CAMK2D	transfac_pro__M00938	E2F1 (directAnnotation).
CAMK2D	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CAMK2D	transfac_pro__M02090	E2F4 (directAnnotation).
CAMK2D	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CAMK2D	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CAMK2D	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CAMK2D	transfac_pro__M01303	SP1 (directAnnotation).
CAMK2D	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CAMK2D	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
CAMK2D	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
CAMK2D	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CAMK2D	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CAMK2D	"(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SUL	DB08039	small molecule
CAMK2D	"2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonit	DB07853	small molecule
CAMK2D	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."