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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CADM1

Summary for CADM1

Gene information	Gene symbol	CADM1
	Ensembl ID	ENSG00000182985
	Entrez ID	23705
	Gene name	cell adhesion molecule 1
	Synonyms	BL2\|IGSF4\|IGSF4A\|Necl-2\|NECL2\|RA175\|ST17\|SYNCAM\|SYNCAM1\|TSLC1
	Gene type	protein_coding
	UniProtAcc	Q9BY67

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Dataset with differentially expressed gene: CADM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.15559	1.25e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.399739	9.14e-19
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.283033	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-1.01096	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.927467	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.470665	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.544319	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.463883	2.41e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.624642	0.00e+00

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Expression of CADM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CADM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE161801_IMiD	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE161801_IMiD	pre	resistant
CADM1	Malignant cells	CPI-SS0B990492C	CADM1_NECTIN3	CADM1	NECTIN3	False	Malignant cells	Fibroblasts	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	cDCs	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	cDCs	Malignant cells	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0B990492C	CADM1_NECTIN3	CADM1	NECTIN3	False	Malignant cells	Fibroblasts	GSE189460	pre	sensitive
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE189460	pre	sensitive
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Endothelial cells	Malignant cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Endothelial cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Plasma cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Plasma cells	Malignant cells	GSE207422_Tor	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CADM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CADM1	hsa-miR-5688	99.9648	NM_001098517
CADM1	hsa-miR-495-3p	99.964	NM_001098517
CADM1	hsa-miR-5011-5p	99.5329	NM_014333
CADM1	hsa-miR-3133	98.2658	NM_001098517
CADM1	hsa-miR-3148	98.1778	NM_014333
CADM1	hsa-miR-190a-3p	98.1312	NM_001098517
CADM1	hsa-miR-194-5p	96.3854	NM_001098517
CADM1	hsa-miR-6837-3p	95.8717	NM_014333
CADM1	hsa-miR-3692-3p	95.792	NM_001098517
CADM1	hsa-miR-205-5p	95.7196	NM_001098517
CADM1	hsa-miR-522-3p	95.5989	NM_001098517
CADM1	hsa-miR-224-3p	95.5989	NM_001098517
CADM1	hsa-miR-4668-5p	95.2811	NM_001098517
CADM1	hsa-miR-4668-3p	95.152	NM_001098517
CADM1	hsa-miR-34a-3p	94.8743	NM_001098517
CADM1	hsa-miR-4795-3p	94.7659	NM_014333
CADM1	hsa-miR-597-3p	94.564	NM_001098517
CADM1	hsa-miR-6784-3p	94.5124	NM_001098517
CADM1	hsa-miR-4324	94.2861	NM_001098517
CADM1	hsa-miR-9983-3p	94.184	NM_014333
CADM1	hsa-miR-182-3p	94.1709	NM_001098517
CADM1	hsa-miR-3143	94.0688	NM_001098517
CADM1	hsa-miR-4642	93.9053	NM_001098517
CADM1	hsa-miR-651-3p	93.8723	NM_014333
CADM1	hsa-miR-4775	93.8	NM_014333
CADM1	hsa-miR-12113	93.1435	NM_014333
CADM1	hsa-miR-6862-3p	92.9842	NM_001098517
CADM1	hsa-miR-1229-3p	92.8849	NM_001098517
CADM1	hsa-miR-10526-3p	92.5907	NM_001098517
CADM1	hsa-miR-129-5p	92.5812	NM_014333
CADM1	hsa-miR-4539	91.5038	NM_014333
CADM1	hsa-miR-4791	91.4372	NM_001098517
CADM1	hsa-miR-3658	91.4058	NM_001098517
CADM1	hsa-miR-4708-5p	91.2151	NM_001098517
CADM1	hsa-miR-6794-3p	90.9033	NM_014333
CADM1	hsa-miR-548c-3p	90.0782	NM_001098517
CADM1	hsa-miR-4329	89.9049	NM_001098517
CADM1	hsa-miR-510-3p	89.5167	NM_014333
CADM1	hsa-miR-558	89.2753	NM_001098517
CADM1	hsa-miR-3201	89.1639	NM_001098517
CADM1	hsa-miR-300	88.4618	NM_001098517
CADM1	hsa-miR-381-3p	88.4618	NM_001098517
CADM1	hsa-miR-545-3p	88.4472	NM_001098517
CADM1	hsa-let-7b-3p	88.2992	NM_001098517
CADM1	hsa-let-7a-3p	88.2992	NM_001098517
CADM1	hsa-let-7f-1-3p	88.2992	NM_001098517
CADM1	hsa-miR-98-3p	88.2992	NM_001098517
CADM1	hsa-miR-2909	88.0983	NM_014333
CADM1	hsa-miR-3922-3p	87.5917	NM_014333
CADM1	hsa-miR-3176	87.5917	NM_014333

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Motifs and transcription factors (TFs) regulating CADM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CADM1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CADM1	transfac_pro__M00652	NRF1 (directAnnotation).
CADM1	transfac_pro__M01298	MECP2 (directAnnotation).
CADM1	jaspar__MA0079.5	SP1 (directAnnotation).
CADM1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
CADM1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
CADM1	transfac_pro__M01253	CNOT3 (directAnnotation).
CADM1	hdpi__NFIX	NFIX (directAnnotation).
CADM1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CADM1	transfac_pro__M05712	ZNF134 (directAnnotation).
CADM1	cisbp__M07938	E2F1 (directAnnotation).
CADM1	transfac_pro__M06766	ZNF835 (directAnnotation).
CADM1	tfdimers__MD00016	MYCN (directAnnotation).
CADM1	metacluster_27.12	ZNF274 (directAnnotation).
CADM1	metacluster_29.4	BCL6; BCL6; BCL6; BCL6; BCL6B; BCL6B; BCL6B; BCL6B; BCL6B (directAnnotation). BCL6; BCL6; BCL6 (inferredBy_Orthology).
CADM1	transfac_pro__M05770	ZNF77 (directAnnotation).
CADM1	transfac_pro__M06280	ZFP69 (directAnnotation).
CADM1	transfac_pro__M06226	ZNF460 (directAnnotation).
CADM1	transfac_pro__M06468	ZNF808 (directAnnotation).
CADM1	transfac_pro__M12697	ZNF142 (directAnnotation).
CADM1	cisbp__M00341	PAX6 (directAnnotation).
CADM1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CADM1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
CADM1	transfac_pro__M02089	E2F3 (directAnnotation).
CADM1	transfac_pro__M03806	ZBTB7C (directAnnotation).
CADM1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CADM1	tfdimers__MD00483	ZBTB14 (directAnnotation).
CADM1	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
CADM1	tfdimers__MD00364	WT1 (directAnnotation).
CADM1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CADM1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CADM1	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."