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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: C3orf14

Summary for C3orf14

Gene information	Gene symbol	C3orf14
	Ensembl ID	ENSG00000114405
	Entrez ID	57415
	Gene name	chromosome 3 open reading frame 14
	Synonyms	HT021
	Gene type	protein_coding
	UniProtAcc	Q9HBI5

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Dataset with differentially expressed gene: C3orf14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.11332	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.497226	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.626796	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.56173	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.518459	6.98e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.293949	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.357272	0.00e+00

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Expression of C3orf14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to C3orf14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating C3orf14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C3orf14	hsa-miR-6505-3p	94.5119	NM_001291943
C3orf14	hsa-miR-548p	93.6191	NM_020685
C3orf14	hsa-miR-758-3p	92.8734	NM_020685
C3orf14	hsa-miR-3148	90.7248	NM_020685
C3orf14	hsa-miR-3184-3p	90.286	NM_001291943
C3orf14	hsa-miR-371b-5p	89.8548	NM_020685
C3orf14	hsa-miR-373-5p	89.8548	NM_020685
C3orf14	hsa-miR-616-5p	89.8548	NM_020685
C3orf14	hsa-miR-570-3p	89.3775	NM_001291941
C3orf14	hsa-miR-3153	87.7069	NM_020685
C3orf14	hsa-miR-3158-5p	87.3488	NM_020685
C3orf14	hsa-miR-6733-5p	87.0207	NM_020685
C3orf14	hsa-miR-6739-5p	87.0207	NM_020685
C3orf14	hsa-miR-30c-5p	86.2754	NM_020685
C3orf14	hsa-miR-30b-5p	86.2754	NM_020685
C3orf14	hsa-miR-30d-5p	86.2754	NM_020685
C3orf14	hsa-miR-30e-5p	86.2754	NM_020685
C3orf14	hsa-miR-30a-5p	86.2754	NM_020685
C3orf14	hsa-miR-4306	86.198	NM_020685
C3orf14	hsa-miR-6740-3p	85.2513	NM_020685
C3orf14	hsa-miR-7977	81.9009	NM_020685
C3orf14	hsa-miR-2278	80.8296	NM_020685
C3orf14	hsa-miR-185-5p	80.16	NM_020685
C3orf14	hsa-miR-4644	80.16	NM_020685

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Motifs and transcription factors (TFs) regulating C3orf14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C3orf14	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
C3orf14	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
C3orf14	jaspar__MA1933.1	SREBF2 (directAnnotation).
C3orf14	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
C3orf14	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."