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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BAZ1B

Summary for BAZ1B

Gene information	Gene symbol	BAZ1B
	Ensembl ID	ENSG00000009954
	Entrez ID	9031
	Gene name	bromodomain adjacent to zinc finger domain 1B
	Synonyms	WBSCR10\|WBSCR9\|WSTF
	Gene type	protein_coding
	UniProtAcc	Q9UIG0

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Dataset with differentially expressed gene: BAZ1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-2.08053	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.255612	2.08e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.423659	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.352826	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.250842	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.251836	8.74e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.636337	0.00e+00

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Expression of BAZ1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BAZ1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BAZ1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BAZ1B	hsa-miR-708-3p	97.4975	NM_032408
BAZ1B	hsa-miR-125b-2-3p	94.4017	NM_032408
BAZ1B	hsa-miR-7151-5p	93.0848	NM_032408
BAZ1B	hsa-miR-138-5p	91.9217	NM_032408
BAZ1B	hsa-miR-4774-3p	91.7781	NM_032408
BAZ1B	hsa-miR-4801	90.1501	NM_032408
BAZ1B	hsa-miR-92a-2-5p	89.9219	NM_032408
BAZ1B	hsa-miR-4731-3p	89.7659	NM_032408
BAZ1B	hsa-let-7b-3p	89.0882	NM_032408
BAZ1B	hsa-miR-6766-5p	86.4476	NM_032408
BAZ1B	hsa-miR-6756-5p	86.4476	NM_032408
BAZ1B	hsa-miR-515-3p	86.2088	NM_032408
BAZ1B	hsa-miR-4659b-3p	86.1051	NM_032408
BAZ1B	hsa-miR-4659a-3p	86.1051	NM_032408
BAZ1B	hsa-miR-10a-5p	85.2267	NM_032408
BAZ1B	hsa-miR-10b-5p	85.2267	NM_032408
BAZ1B	hsa-miR-6131	85.0178	NM_032408
BAZ1B	hsa-miR-133a-5p	85.0178	NM_032408
BAZ1B	hsa-miR-2116-5p	84.6561	NM_032408
BAZ1B	hsa-miR-22-5p	84.6561	NM_032408
BAZ1B	hsa-miR-183-5p	84.5564	NM_032408
BAZ1B	hsa-miR-33b-3p	84.3807	NM_032408
BAZ1B	hsa-miR-519e-3p	84.3807	NM_032408
BAZ1B	hsa-miR-98-3p	84.3238	NM_032408
BAZ1B	hsa-let-7a-3p	84.3238	NM_032408
BAZ1B	hsa-let-7f-1-3p	84.3238	NM_032408
BAZ1B	hsa-miR-8071	83.1973	NM_032408
BAZ1B	hsa-miR-6748-5p	83.1244	NM_032408
BAZ1B	hsa-miR-4656	81.8969	NM_032408
BAZ1B	hsa-miR-8063	80.6616	NM_032408
BAZ1B	hsa-miR-4666a-3p	80.2546	NM_032408

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Motifs and transcription factors (TFs) regulating BAZ1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BAZ1B	transfac_pro__M04748	GABPA (directAnnotation).
BAZ1B	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
BAZ1B	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
BAZ1B	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
BAZ1B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
BAZ1B	cisbp__M02645	ETS1 (directAnnotation).
BAZ1B	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
BAZ1B	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
BAZ1B	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
BAZ1B	metacluster_81.7	CREB1 (directAnnotation).
BAZ1B	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
BAZ1B	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."