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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: BACH1

Summary for BACH1

Gene information	Gene symbol	BACH1
	Ensembl ID	ENSG00000156273
	Entrez ID	571
	Gene name	BTB domain and CNC homolog 1
	Synonyms	BACH-1\|BTBD24
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BACH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.980684	7.86e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.272709	1.84e-04
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.303458	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.258864	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.328428	1.17e-02
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.286636	4.08e-24
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.280454	7.99e-44
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.31196	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.754364	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.255778	3.18e-43

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Expression of BACH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BACH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BACH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BACH1	hsa-miR-8485	99.7015	NM_001186
BACH1	hsa-miR-155-5p	99.0608	NM_001186
BACH1	hsa-miR-4500	96.8767	NM_001186
BACH1	hsa-let-7e-5p	95.6205	NM_001186
BACH1	hsa-let-7g-5p	95.6205	NM_001186
BACH1	hsa-let-7f-5p	95.6205	NM_001186
BACH1	hsa-let-7a-5p	95.6205	NM_001186
BACH1	hsa-let-7b-5p	95.6205	NM_001186
BACH1	hsa-miR-98-5p	95.6205	NM_001186
BACH1	hsa-let-7c-5p	95.6205	NM_001186
BACH1	hsa-let-7i-5p	95.6205	NM_001186
BACH1	hsa-miR-4458	94.939	NM_001186
BACH1	hsa-let-7d-5p	94.939	NM_001186
BACH1	hsa-miR-3162-5p	93.1992	NM_001186
BACH1	hsa-miR-135a-5p	91.7519	NM_001186
BACH1	hsa-miR-135b-5p	91.7519	NM_001186
BACH1	hsa-miR-2052	90.7652	NM_001186
BACH1	hsa-miR-6760-5p	90.5793	NM_001186
BACH1	hsa-miR-140-5p	90.5569	NM_001186
BACH1	hsa-miR-12124	90.4012	NM_001186
BACH1	hsa-miR-4451	89.9476	NM_001186
BACH1	hsa-miR-1303	89.8978	NM_001186
BACH1	hsa-miR-5580-5p	89.7761	NM_001186
BACH1	hsa-miR-33a-5p	89.6616	NM_001186
BACH1	hsa-miR-33b-5p	89.6616	NM_001186
BACH1	hsa-miR-380-5p	88.7304	NM_001186
BACH1	hsa-miR-4768-3p	88.1727	NM_001186
BACH1	hsa-miR-153-5p	87.9723	NM_001186
BACH1	hsa-miR-563	87.1014	NM_001186
BACH1	hsa-miR-607	85.9937	NM_001186
BACH1	hsa-miR-4797-3p	85.8757	NM_001186
BACH1	hsa-miR-4670-3p	84.8814	NM_001186
BACH1	hsa-miR-4516	84.4743	NM_001186
BACH1	hsa-miR-3622b-3p	83.8217	NM_001186
BACH1	hsa-miR-3622a-3p	83.8217	NM_001186
BACH1	hsa-miR-545-5p	83.0967	NM_001186
BACH1	hsa-miR-31-3p	82.6668	NM_001186
BACH1	hsa-miR-4460	82.3371	NM_001186
BACH1	hsa-miR-6165	82.0423	NM_001186
BACH1	hsa-miR-4660	81.9738	NM_001186
BACH1	hsa-miR-3123	81.8226	NM_001186
BACH1	hsa-miR-548s	81.512	NM_001186
BACH1	hsa-miR-656-3p	81.3484	NM_001186

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Motifs and transcription factors (TFs) regulating BACH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BACH1	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
BACH1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
BACH1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
BACH1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
BACH1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BACH1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
BACH1	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
BACH1	transfac_pro__M01973	PLAG1 (directAnnotation).
BACH1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BACH1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
BACH1	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
BACH1	cisbp__M01864	EGR1 (inferredBy_Orthology).
BACH1	tfdimers__MD00391	KLF4 (directAnnotation).
BACH1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
BACH1	tfdimers__MD00151	CHURC1 (directAnnotation).
BACH1	transfac_pro__M04817	ZBTB33 (directAnnotation).
BACH1	cisbp__M00139	ZNF281 (inferredBy_Orthology).
BACH1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
BACH1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
BACH1	transfac_public__M00491	PATZ1 (directAnnotation).
BACH1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
BACH1	jaspar__MA1122.1	TFDP1 (directAnnotation).
BACH1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
BACH1	transfac_pro__M01253	CNOT3 (directAnnotation).
BACH1	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
BACH1	cisbp__M00968	MTF2 (directAnnotation).
BACH1	tfdimers__MD00038	TFAP2C (directAnnotation).
BACH1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
BACH1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
BACH1	transfac_pro__M01199	TRIM28 (directAnnotation).
BACH1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
BACH1	metacluster_3.14	WT1; WT1 (directAnnotation).
BACH1	transfac_pro__M12697	ZNF142 (directAnnotation).
BACH1	metacluster_84.2	RARA (directAnnotation).
BACH1	transfac_pro__M01122	ZNF219 (directAnnotation).
BACH1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
BACH1	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
BACH1	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
BACH1	transfac_pro__M00986	CHURC1 (directAnnotation).
BACH1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
BACH1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
BACH1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSNNNNCRMN_CAP	E2F3; TBX21 (directAnnotation).
BACH1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
BACH1	cisbp__M00249	WT1 (directAnnotation).
BACH1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
BACH1	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
BACH1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
BACH1	transfac_public__M00373	PAX4 (directAnnotation).
BACH1	transfac_pro__M01714	KLF15 (directAnnotation).
BACH1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
BACH1	metacluster_22.37	up	Mono/Macro	GSE164551	NA
BACH1	metacluster_157.2	up	Mono/Macro	GSE164551	NA
BACH1	metacluster_30.4	up	Mono/Macro	GSE164551	NA
BACH1	metacluster_157.2	down	Mono/Macro	GSE169246_PacAteBlood	post
BACH1	tfdimers__MD00476	up	Mono/Macro	GSE197268_Tisa-cel	pre
BACH1	metacluster_22.37	up	Mono/Macro	GSE197268_Tisa-cel	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."