Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ATF3

Summary for ATF3

Gene information	Gene symbol	ATF3
	Ensembl ID	ENSG00000162772
	Entrez ID	467
	Gene name	activating transcription factor 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: ATF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.99857	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.452174	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.437927	1.21e-24
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	1.63723	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.89537	5.47e-14
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.810729	1.19e-07
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.427281	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.637271	7.78e-31
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.53241	3.07e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.313586	1.93e-10
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.405421	1.80e-24
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-1.44412	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.735667	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.976353	1.63e-30
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	1.00352	4.81e-30
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.09542	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	1.34451	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.267149	1.91e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.421702	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.34016	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.358007	1.78e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.310206	3.59e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.308383	1.30e-09
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-1.30797	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.449314	0.00e+00

Top

Expression of ATF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ATF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ATF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATF3	hsa-miR-4251	97.2607	NM_001206486
ATF3	hsa-miR-600	95.0353	NM_001206486
ATF3	hsa-miR-6823-5p	94.8682	NM_001030287
ATF3	hsa-miR-3200-5p	93.695	NM_001206486
ATF3	hsa-miR-4435	92.0591	NM_001206486
ATF3	hsa-miR-4640-5p	90.2261	NM_001040619
ATF3	hsa-miR-6809-3p	90.1386	NM_001040619
ATF3	hsa-miR-4726-5p	90.1365	NM_001040619
ATF3	hsa-miR-6868-3p	89.7409	NM_001206486
ATF3	hsa-miR-218-1-3p	88.7034	NM_001030287
ATF3	hsa-miR-6761-5p	87.2245	NM_001206486
ATF3	hsa-miR-3194-3p	84.0723	NM_001206486
ATF3	hsa-miR-4329	84.0533	NM_001206486
ATF3	hsa-miR-486-3p	82.6482	NM_001030287
ATF3	hsa-miR-4778-3p	82.456	NM_001040619
ATF3	hsa-miR-1261	81.4681	NM_001040619
ATF3	hsa-miR-6751-3p	81.0533	NM_001040619
ATF3	hsa-miR-1199-5p	81.0533	NM_001040619
ATF3	hsa-miR-4422	80.8865	NM_001030287
ATF3	hsa-miR-5692a	80.3257	NM_001206486

Page: 1

Top

Motifs and transcription factors (TFs) regulating ATF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATF3	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
ATF3	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
ATF3	transfac_public__M00040	ATF2 (directAnnotation).
ATF3	transfac_pro__M07436	WT1 (directAnnotation).
ATF3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ATF3	metacluster_3.14	WT1; WT1 (directAnnotation).
ATF3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATF3	hdpi__TFAM	TFAM (directAnnotation).
ATF3	transfac_pro__M07329	SP7 (directAnnotation).
ATF3	transfac_pro__M01122	ZNF219 (directAnnotation).
ATF3	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ATF3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATF3	transfac_pro__M08819	KLF2 (directAnnotation).
ATF3	transfac_public__M00415	ZEB1 (directAnnotation).
ATF3	transfac_pro__M01175	ZBTB7B (directAnnotation).
ATF3	transfac_pro__M01118	WT1 (directAnnotation).
ATF3	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ATF3	transfac_pro__M01303	SP1 (directAnnotation).
ATF3	transfac_pro__M04595	SALL2 (directAnnotation).
ATF3	transfac_pro__M01837	KLF11 (directAnnotation).
ATF3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ATF3	transfac_pro__M00716	ZBTB14 (directAnnotation).
ATF3	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ATF3	transfac_pro__M07397	ZNF148 (directAnnotation).
ATF3	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
ATF3	transfac_pro__M01104	OVOL2 (directAnnotation).
ATF3	transfac_pro__M00986	CHURC1 (directAnnotation).
ATF3	metacluster_22.19	NFE2 (directAnnotation).
ATF3	metacluster_22.37	BACH1 (directAnnotation).
ATF3	metacluster_22.34	BACH2 (directAnnotation).
ATF3	metacluster_22.20	MAFG (directAnnotation).
ATF3	cisbp__M01815	CEBPE (inferredBy_Orthology).
ATF3	metacluster_22.33	MAFK (inferredBy_Orthology).
ATF3	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
ATF3	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ATF3	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
ATF3	transfac_pro__M04916	TAF1 (directAnnotation).
ATF3	metacluster_22.17	NFE2 (directAnnotation).
ATF3	metacluster_111.5	E4F1; E4F1 (directAnnotation).
ATF3	transfac_pro__M06408	ZSCAN30 (directAnnotation).
ATF3	jaspar__MA0502.2	NFYB (directAnnotation).
ATF3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ATF3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ATF3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ATF3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ATF3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ATF3	hdpi__TP73	TP73 (directAnnotation).
ATF3	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
ATF3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
ATF3	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).

Page: 1 2 3 4 5 6

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ATF3	metacluster_57.3	down	Malignant cells	GSE131984_JQ1	NA
ATF3	metacluster_57.3	down	Malignant cells	GSE131984_JQ1Pal	NA
ATF3	metacluster_137.2	down	Malignant cells	GSE131984_Pac	NA
ATF3	metacluster_57.3	down	Malignant cells	GSE131984_Pac	NA
ATF3	metacluster_156.2	up	Malignant cells	GSE139386	NA
ATF3	metacluster_111.3	down	Malignant cells	GSE153697	NA
ATF3	metacluster_156.2	down	Malignant cells	GSE161801_IMiD	post
ATF3	metacluster_157.2	down	Mono/Macro	GSE164551	NA
ATF3	metacluster_137.2	down	Mono/Macro	GSE164551	NA
ATF3	metacluster_57.3	down	Malignant cells	GSE168668	NA
ATF3	metacluster_57.3	up	Mono/Macro	GSE169246_PacAteTissue	post
ATF3	transfac_pro__M00801	down	cDCs	GSE169246_PacTissue	post
ATF3	metacluster_157.2	down	cDCs	GSE169246_PacTissue	post
ATF3	metacluster_137.2	down	cDCs	GSE169246_PacTissue	post
ATF3	metacluster_157.2	down	Mono/Macro	GSE169246_PacTissue	post
ATF3	metacluster_137.2	down	Mono/Macro	GSE169246_PacTissue	post
ATF3	metacluster_111.4	up	CD8+ T cells	GSE169246_PacTissue	pre
ATF3	metacluster_111.3	up	CD8+ T cells	GSE169246_PacTissue	pre
ATF3	metacluster_157.2	up	CD8+ T cells	GSE169246_PacTissue	pre
ATF3	metacluster_148.1	up	CD8+ T cells	GSE169246_PacTissue	pre
ATF3	metacluster_156.2	up	Malignant cells	GSE186960	NA
ATF3	metacluster_173.2	up	Malignant cells	GSE207422_Tor	post
ATF3	metacluster_180.3	up	Plasma cells	GSE207422_Tor	post
ATF3	metacluster_111.3	down	CD4+ T cells	PMID34715028	post
ATF3	transfac_pro__M00801	down	CD4+ T cells	PMID34715028	post
ATF3	metacluster_111.4	down	CD4+ T cells	PMID34715028	post
ATF3	metacluster_148.1	down	CD4+ T cells	PMID34715028	post
ATF3	transfac_pro__M07981	down	CD4+ T cells	PMID34715028	post
ATF3	metacluster_180.3	down	CD4+ T cells	PMID34715028	post
ATF3	metacluster_111.3	down	CD8+ T cells	PMID34715028	post
ATF3	transfac_pro__M00801	down	CD8+ T cells	PMID34715028	post
ATF3	metacluster_111.4	down	CD8+ T cells	PMID34715028	post
ATF3	metacluster_148.1	down	CD8+ T cells	PMID34715028	post

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."