Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ASPH

Summary for ASPH

Gene information	Gene symbol	ASPH
	Ensembl ID	ENSG00000198363
	Entrez ID	444
	Gene name	aspartate beta-hydroxylase
	Synonyms	BAH\|CASQ2BP1\|HAAH\|JCTN
	Gene type	protein_coding
	UniProtAcc	Q12797

Top

Dataset with differentially expressed gene: ASPH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.813615	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.287955	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.53156	7.14e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.398978	1.38e-06
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.88389	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.392664	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.256016	7.83e-09
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.256561	0.00e+00

Top

Expression of ASPH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ASPH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ASPH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASPH	hsa-miR-4307	98.3897	NM_020164
ASPH	hsa-miR-6842-3p	96.2821	NM_001164750
ASPH	hsa-miR-4276	95.4836	NM_001164756
ASPH	hsa-miR-3133	95.2663	NM_001164756
ASPH	hsa-miR-27b-3p	95.0194	NM_001164750
ASPH	hsa-miR-27a-3p	95.0194	NM_001164750
ASPH	hsa-miR-9985	95.0194	NM_001164750
ASPH	hsa-miR-3121-3p	94.8488	NM_020164
ASPH	hsa-miR-590-3p	93.8787	NM_001164756
ASPH	hsa-miR-6501-3p	93.5301	NM_020164
ASPH	hsa-miR-576-5p	93.5193	NM_001164753
ASPH	hsa-miR-4503	93.5108	NM_020164
ASPH	hsa-miR-4531	93.4575	NM_001164750
ASPH	hsa-miR-4263	93.3416	NM_001164753
ASPH	hsa-miR-24-2-5p	92.9365	NM_001164756
ASPH	hsa-miR-24-1-5p	92.9365	NM_001164756
ASPH	hsa-miR-3191-5p	92.921	NM_001164756
ASPH	hsa-miR-513b-5p	92.8134	NM_001164753
ASPH	hsa-miR-3163	92.7338	NM_020164
ASPH	hsa-miR-1258	92.201	NM_001164750
ASPH	hsa-miR-539-5p	91.9843	NM_001164750
ASPH	hsa-miR-10523-5p	91.9378	NM_001164753
ASPH	hsa-miR-2110	91.924	NM_001164753
ASPH	hsa-miR-497-3p	91.8297	NM_001164753
ASPH	hsa-miR-376c-3p	91.5895	NM_001164756
ASPH	hsa-miR-1252-3p	91.5409	NM_001164750
ASPH	hsa-miR-642b-5p	91.5196	NM_001164756
ASPH	hsa-miR-4698	91.4731	NM_001164753
ASPH	hsa-miR-3662	91.4134	NM_001164753
ASPH	hsa-miR-3907	90.985	NM_001164750
ASPH	hsa-miR-6727-3p	90.8349	NM_001164753
ASPH	hsa-miR-3140-3p	90.5312	NM_020164
ASPH	hsa-miR-411-3p	89.8773	NM_001164753
ASPH	hsa-miR-379-3p	89.8773	NM_001164753
ASPH	hsa-miR-3152-3p	89.7396	NM_001164756
ASPH	hsa-miR-513b-3p	89.6339	NM_001164750
ASPH	hsa-miR-4262	89.6299	NM_020164
ASPH	hsa-miR-4775	89.3205	NM_001164756
ASPH	hsa-miR-620	89.0782	NM_020164
ASPH	hsa-miR-1286	88.695	NM_001164753
ASPH	hsa-miR-6797-3p	88.6137	NM_001164750
ASPH	hsa-miR-499a-5p	88.4367	NM_020164
ASPH	hsa-miR-4282	88.3162	NM_001164756
ASPH	hsa-miR-1270	88.0968	NM_020164
ASPH	hsa-miR-6076	88.0745	NM_001164750
ASPH	hsa-miR-452-3p	87.6488	NM_001164750
ASPH	hsa-miR-498-3p	87.3928	NM_020164
ASPH	hsa-miR-4722-3p	87.0463	NM_001164753
ASPH	hsa-miR-130b-5p	87.0301	NM_001164750
ASPH	hsa-miR-4653-3p	86.9621	NM_001164756

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating ASPH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASPH	transfac_pro__M04950	EGR1 (directAnnotation).
ASPH	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
ASPH	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ASPH	transfac_pro__M06111	ZNF254 (directAnnotation).
ASPH	transfac_pro__M06126	ZNF43 (directAnnotation).
ASPH	taipale_tf_pairs__GCM2_MAX_NTRNGGGNNNCACGTG_CAP_repr	GCM2; MAX (directAnnotation).
ASPH	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
ASPH	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
ASPH	metacluster_144.12	ZNF419; ZNF773 (directAnnotation).
ASPH	transfac_pro__M02090	E2F4 (directAnnotation).
ASPH	hdpi__HIP2	UBE2K (directAnnotation).
ASPH	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ASPH	metacluster_22.1	MAFF (inferredBy_Orthology).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ASPH	"Aspartic acid"	DB00128	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."