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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARID5B

Summary for ARID5B

Gene information	Gene symbol	ARID5B
	Ensembl ID	ENSG00000150347
	Entrez ID	84159
	Gene name	AT-rich interaction domain 5B
	Synonyms	FLJ21150\|MRF2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARID5B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.260186	1.12e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.252779	1.88e-22
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.356584	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.51409	6.46e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.276997	9.39e-07
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.466089	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.336403	5.43e-24
GSE150930	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Mucosa-assisted lymphoid tissue (MALT) lymphoma	Immunotherapy	rituximab + cyclophosphamide + fludarabine	NA	Malignant cells	-0.264971	1.21e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.866521	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.39535	1.14e-10
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.27177	3.84e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.506849	1.96e-08
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.381681	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.342971	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.2925	1.26e-37
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.510459	0.00e+00

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Expression of ARID5B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARID5B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARID5B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARID5B	hsa-miR-3191-5p	99.2437	NM_001244638
ARID5B	hsa-miR-4753-3p	98.9557	NM_001244638
ARID5B	hsa-miR-5011-5p	98.7095	NM_001244638
ARID5B	hsa-miR-6809-3p	96.0687	NM_001244638
ARID5B	hsa-miR-3977	94.6853	NM_001244638
ARID5B	hsa-miR-33a-5p	93.0889	NM_001244638
ARID5B	hsa-miR-33b-5p	93.0889	NM_001244638
ARID5B	hsa-miR-4296	93.0312	NM_001244638
ARID5B	hsa-miR-410-3p	91.9117	NM_001244638
ARID5B	hsa-miR-518c-5p	91.7136	NM_001244638
ARID5B	hsa-miR-767-3p	91.0514	NM_001244638
ARID5B	hsa-miR-6852-3p	90.8135	NM_001244638
ARID5B	hsa-miR-302e	90.7494	NM_001244638
ARID5B	hsa-miR-3182	90.2897	NM_001244638
ARID5B	hsa-miR-3658	89.3532	NM_001244638
ARID5B	hsa-miR-190a-3p	89.2291	NM_001244638
ARID5B	hsa-miR-302c-3p	89.1276	NM_001244638
ARID5B	hsa-miR-302b-3p	89.1276	NM_001244638
ARID5B	hsa-miR-302a-3p	89.1276	NM_001244638
ARID5B	hsa-miR-302d-3p	89.1276	NM_001244638
ARID5B	hsa-miR-4698	88.8583	NM_001244638
ARID5B	hsa-miR-1302	88.7127	NM_001244638
ARID5B	hsa-miR-182-3p	88.4827	NM_001244638
ARID5B	hsa-miR-373-3p	88.2204	NM_001244638
ARID5B	hsa-miR-520b-3p	88.2204	NM_001244638
ARID5B	hsa-miR-520c-3p	88.2204	NM_001244638
ARID5B	hsa-miR-520a-3p	88.2204	NM_001244638
ARID5B	hsa-miR-520e-3p	88.2204	NM_001244638
ARID5B	hsa-miR-520d-3p	88.2204	NM_001244638
ARID5B	hsa-miR-372-3p	88.2204	NM_001244638
ARID5B	hsa-miR-4265	87.5991	NM_001244638
ARID5B	hsa-miR-4322	87.5991	NM_001244638
ARID5B	hsa-miR-1277-5p	87.2827	NM_001244638
ARID5B	hsa-miR-30e-5p	87.238	NM_001244638
ARID5B	hsa-miR-30b-5p	87.238	NM_001244638
ARID5B	hsa-miR-30d-5p	87.238	NM_001244638
ARID5B	hsa-miR-30a-5p	87.238	NM_001244638
ARID5B	hsa-miR-30c-5p	87.238	NM_001244638
ARID5B	hsa-miR-7158-5p	86.8854	NM_001244638
ARID5B	hsa-miR-338-5p	86.6724	NM_001244638
ARID5B	hsa-miR-3148	86.1798	NM_001244638
ARID5B	hsa-miR-3688-5p	85.9974	NM_001244638
ARID5B	hsa-miR-4433a-5p	85.9827	NM_001244638
ARID5B	hsa-miR-6764-3p	85.7872	NM_001244638
ARID5B	hsa-miR-6824-3p	85.7872	NM_001244638
ARID5B	hsa-miR-5011-3p	85.5826	NM_001244638
ARID5B	hsa-miR-101-3p	85.2045	NM_001244638
ARID5B	hsa-miR-4298	85.0721	NM_001244638
ARID5B	hsa-miR-597-3p	84.8867	NM_001244638
ARID5B	hsa-miR-3659	84.4283	NM_001244638

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Motifs and transcription factors (TFs) regulating ARID5B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARID5B	transfac_pro__M06130	ZNF254 (directAnnotation).
ARID5B	dbtfbs__DACH1_K562_ENCSR030TJP_merged_N1	DACH1 (directAnnotation).
ARID5B	transfac_pro__M06715	ZNF331 (directAnnotation).
ARID5B	transfac_pro__M06568	ZNF501 (directAnnotation).
ARID5B	transfac_pro__M06777	ZNF214 (directAnnotation).
ARID5B	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ARID5B	taipale_tf_pairs__HOXB13_ETV1_RSCGGAARYNNTAAAN_CAP_repr	ETV1; HOXB13 (directAnnotation).
ARID5B	transfac_pro__M06071	ZNF814 (directAnnotation).
ARID5B	transfac_pro__M06239	ZNF844 (directAnnotation).
ARID5B	transfac_pro__M05572	ZFP91; ZFP91-CNTF (inferredBy_Orthology).
ARID5B	metacluster_14.20	TFEB (directAnnotation).
ARID5B	taipale_tf_pairs__TEAD4_DRGX_GGAATGTTAATTR_CAP	DRGX; TEAD4 (directAnnotation).
ARID5B	transfac_pro__M05956	BCL11B (directAnnotation).
ARID5B	jaspar__MA1562.1	SOX14 (directAnnotation).
ARID5B	metacluster_14.23	TFE3 (directAnnotation).
ARID5B	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
ARID5B	transfac_pro__M06111	ZNF254 (directAnnotation).
ARID5B	transfac_pro__M06084	ZNF208 (directAnnotation).
ARID5B	taipale_cyt_meth__LBX2_CTMATTAATTAN_eDBD	LBX2 (directAnnotation).
ARID5B	transfac_pro__M05794	ZNF621 (directAnnotation).
ARID5B	transfac_pro__M05706	ZNF20 (directAnnotation).
ARID5B	metacluster_9.13	LHX8 (directAnnotation).
ARID5B	hdpi__TCEAL2	TCEAL2 (directAnnotation).
ARID5B	transfac_pro__M06135	ZNF28 (directAnnotation).
ARID5B	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
ARID5B	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
ARID5B	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
ARID5B	transfac_pro__M05981	ZNF233 (directAnnotation).
ARID5B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARID5B	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ARID5B	metacluster_172.6	CHD2; E2F1 (directAnnotation).
ARID5B	transfac_pro__M06141	ZNF708 (directAnnotation).
ARID5B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARID5B	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ARID5B	transfac_pro__M12697	ZNF142 (directAnnotation).
ARID5B	transfac_pro__M06035	ZNF749 (directAnnotation).
ARID5B	cisbp__M07938	E2F1 (directAnnotation).
ARID5B	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
ARID5B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARID5B	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARID5B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ARID5B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ARID5B	transfac_pro__M01175	ZBTB7B (directAnnotation).
ARID5B	metacluster_3.14	WT1; WT1 (directAnnotation).
ARID5B	transfac_pro__M01253	CNOT3 (directAnnotation).
ARID5B	transfac_pro__M02090	E2F4 (directAnnotation).
ARID5B	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ARID5B	transfac_pro__M06229	ZNF91 (directAnnotation).
ARID5B	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ARID5B	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."