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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AP1G1

Summary for AP1G1

Gene information	Gene symbol	AP1G1
	Ensembl ID	ENSG00000166747
	Entrez ID	164
	Gene name	adaptor related protein complex 1 subunit gamma 1
	Synonyms	ADTG\|CLAPG1
	Gene type	protein_coding
	UniProtAcc	O43747

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Dataset with differentially expressed gene: AP1G1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.506869	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.253951	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.354028	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.292712	4.22e-43

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Expression of AP1G1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AP1G1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AP1G1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AP1G1	hsa-miR-4262	98.8491	NM_001030007
AP1G1	hsa-miR-181b-5p	98.4873	NM_001030007
AP1G1	hsa-miR-181c-5p	98.4873	NM_001030007
AP1G1	hsa-miR-181d-5p	98.4873	NM_001030007
AP1G1	hsa-miR-181a-5p	98.4873	NM_001030007
AP1G1	hsa-miR-4481	97.8469	NM_001128
AP1G1	hsa-miR-145-5p	97.7003	NM_001030007
AP1G1	hsa-miR-4745-5p	96.9735	NM_001128
AP1G1	hsa-miR-5195-3p	96.8783	NM_001030007
AP1G1	hsa-miR-373-5p	96.3598	NM_001030007
AP1G1	hsa-miR-371b-5p	96.3598	NM_001030007
AP1G1	hsa-miR-616-5p	96.3598	NM_001030007
AP1G1	hsa-miR-206	96.0717	NM_001030007
AP1G1	hsa-miR-1-3p	96.0717	NM_001030007
AP1G1	hsa-miR-613	96.0717	NM_001030007
AP1G1	hsa-miR-922	95.6212	NM_001030007
AP1G1	hsa-miR-6778-5p	95.0475	NM_001030007
AP1G1	hsa-miR-1233-5p	95.0475	NM_001030007
AP1G1	hsa-miR-4654	94.5386	NM_001030007
AP1G1	hsa-miR-324-5p	93.925	NM_001030007
AP1G1	hsa-miR-3064-5p	93.6585	NM_001030007
AP1G1	hsa-miR-302b-5p	93.396	NM_001030007
AP1G1	hsa-miR-302d-5p	93.396	NM_001030007
AP1G1	hsa-miR-4769-5p	92.8495	NM_001030007
AP1G1	hsa-miR-101-3p	92.3002	NM_001030007
AP1G1	hsa-miR-1238-5p	92.2849	NM_001030007
AP1G1	hsa-miR-4758-5p	92.2849	NM_001030007
AP1G1	hsa-miR-3529-3p	91.7695	NM_001030007
AP1G1	hsa-miR-144-3p	91.1708	NM_001030007
AP1G1	hsa-miR-3085-3p	90.9262	NM_001030007
AP1G1	hsa-miR-6504-5p	90.9262	NM_001030007
AP1G1	hsa-miR-654-3p	89.298	NM_001030007
AP1G1	hsa-miR-4516	88.8003	NM_001030007
AP1G1	hsa-miR-3688-3p	88.7801	NM_001030007
AP1G1	hsa-miR-4482-3p	88.7746	NM_001030007
AP1G1	hsa-miR-3059-5p	88.7081	NM_001030007
AP1G1	hsa-miR-936	88.3377	NM_001030007
AP1G1	hsa-miR-6867-5p	88.3209	NM_001030007
AP1G1	hsa-miR-7155-3p	88.0847	NM_001030007
AP1G1	hsa-miR-3136-3p	88.0847	NM_001030007
AP1G1	hsa-miR-298	87.8504	NM_001030007
AP1G1	hsa-miR-4288	87.2215	NM_001030007
AP1G1	hsa-miR-199b-5p	86.9643	NM_001030007
AP1G1	hsa-miR-199a-5p	86.9643	NM_001030007
AP1G1	hsa-miR-8087	86.6146	NM_001030007
AP1G1	hsa-miR-130b-5p	86.4699	NM_001030007
AP1G1	hsa-miR-3663-3p	85.9879	NM_001030007
AP1G1	hsa-miR-7843-3p	85.7701	NM_001030007
AP1G1	hsa-miR-8485	85.738	NM_001030007
AP1G1	hsa-miR-6736-3p	84.5572	NM_001030007

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Motifs and transcription factors (TFs) regulating AP1G1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AP1G1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
AP1G1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AP1G1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
AP1G1	metacluster_151.2	ZNF23 (directAnnotation).
AP1G1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
AP1G1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AP1G1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
AP1G1	transfac_pro__M01253	CNOT3 (directAnnotation).
AP1G1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
AP1G1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
AP1G1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
AP1G1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
AP1G1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
AP1G1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AP1G1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
AP1G1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
AP1G1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
AP1G1	transfac_pro__M04817	ZBTB33 (directAnnotation).
AP1G1	tfdimers__MD00364	WT1 (directAnnotation).
AP1G1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
AP1G1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
AP1G1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
AP1G1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
AP1G1	tfdimers__MD00483	ZBTB14 (directAnnotation).
AP1G1	transfac_pro__M01303	SP1 (directAnnotation).
AP1G1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
AP1G1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
AP1G1	transfac_pro__M07387	ZBTB7A (directAnnotation).
AP1G1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
AP1G1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
AP1G1	transfac_pro__M00514	ATF4 (directAnnotation).
AP1G1	transfac_pro__M00665	SP3 (directAnnotation).
AP1G1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
AP1G1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
AP1G1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
AP1G1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
AP1G1	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
AP1G1	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
AP1G1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
AP1G1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
AP1G1	transfac_pro__M07329	SP7 (directAnnotation).
AP1G1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
AP1G1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
AP1G1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
AP1G1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
AP1G1	tfdimers__MD00038	TFAP2C (directAnnotation).
AP1G1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."