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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKH

Summary for ANKH

Gene information	Gene symbol	ANKH
	Ensembl ID	ENSG00000154122
	Entrez ID	56172
	Gene name	ANKH inorganic pyrophosphate transport regulator
	Synonyms	ANK\|CCAL2\|CMDJ\|CPPDD\|HANK\|SLC62A1
	Gene type	protein_coding
	UniProtAcc	Q9HCJ1

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Dataset with differentially expressed gene: ANKH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.45285	1.02e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.329044	4.50e-19
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.663598	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.466246	6.09e-31
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.284228	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.398649	0.00e+00

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Expression of ANKH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKH	hsa-miR-218-1-3p	98.6293	NM_054027
ANKH	hsa-miR-3922-5p	96.4557	NM_054027
ANKH	hsa-miR-659-3p	94.3845	NM_054027
ANKH	hsa-miR-20a-5p	94.2636	NM_054027
ANKH	hsa-miR-106b-5p	94.2636	NM_054027
ANKH	hsa-miR-548x-3p	94.1628	NM_054027
ANKH	hsa-miR-548aj-3p	94.1628	NM_054027
ANKH	hsa-miR-548j-3p	93.8791	NM_054027
ANKH	hsa-miR-548am-3p	93.8791	NM_054027
ANKH	hsa-miR-548ae-3p	93.8791	NM_054027
ANKH	hsa-miR-548ah-3p	93.8791	NM_054027
ANKH	hsa-miR-548aq-3p	93.8791	NM_054027
ANKH	hsa-miR-3130-5p	93.8411	NM_054027
ANKH	hsa-miR-20b-5p	93.2168	NM_054027
ANKH	hsa-miR-17-5p	93.2168	NM_054027
ANKH	hsa-miR-519d-3p	93.2168	NM_054027
ANKH	hsa-miR-526b-3p	93.2168	NM_054027
ANKH	hsa-miR-93-5p	93.2168	NM_054027
ANKH	hsa-miR-106a-5p	93.2168	NM_054027
ANKH	hsa-miR-551b-5p	93.0694	NM_054027
ANKH	hsa-miR-4482-5p	92.2768	NM_054027
ANKH	hsa-miR-3146	90.0293	NM_054027
ANKH	hsa-miR-7854-3p	88.6761	NM_054027
ANKH	hsa-miR-758-3p	87.738	NM_054027
ANKH	hsa-miR-4793-5p	87.4008	NM_054027
ANKH	hsa-miR-6781-3p	87.2631	NM_054027
ANKH	hsa-miR-2682-3p	86.9812	NM_054027
ANKH	hsa-miR-6833-3p	86.9525	NM_054027
ANKH	hsa-miR-1253	86.9375	NM_054027
ANKH	hsa-miR-4522	86.6633	NM_054027
ANKH	hsa-miR-4757-5p	86.3674	NM_054027
ANKH	hsa-miR-6744-3p	86.3674	NM_054027
ANKH	hsa-miR-3662	85.5929	NM_054027
ANKH	hsa-miR-221-5p	85.4739	NM_054027
ANKH	hsa-miR-8073	85.4739	NM_054027
ANKH	hsa-miR-3152-5p	85.2618	NM_054027
ANKH	hsa-miR-3646	85.0202	NM_054027
ANKH	hsa-miR-4765	84.7748	NM_054027
ANKH	hsa-miR-6828-5p	84.7128	NM_054027
ANKH	hsa-miR-4768-5p	84.3216	NM_054027
ANKH	hsa-miR-6778-3p	81.9546	NM_054027
ANKH	hsa-miR-1827	81.7349	NM_054027
ANKH	hsa-miR-559	81.2489	NM_054027
ANKH	hsa-miR-10523-5p	80.9659	NM_054027
ANKH	hsa-miR-431-5p	80.9232	NM_054027
ANKH	hsa-miR-130b-5p	80.5717	NM_054027
ANKH	hsa-miR-4775	80.5267	NM_054027
ANKH	hsa-miR-8085	80.3352	NM_054027
ANKH	hsa-miR-6731-5p	80.3352	NM_054027
ANKH	hsa-miR-6750-5p	80.0259	NM_054027

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Motifs and transcription factors (TFs) regulating ANKH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKH	tfdimers__MD00483	ZBTB14 (directAnnotation).
ANKH	cisbp__M00968	MTF2 (directAnnotation).
ANKH	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ANKH	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ANKH	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."