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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AMD1

Summary for AMD1

Gene information	Gene symbol	AMD1
	Ensembl ID	ENSG00000123505
	Entrez ID	262
	Gene name	adenosylmethionine decarboxylase 1
	Synonyms	SAMDC
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AMD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.03668	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.311637	5.27e-12
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.293134	1.51e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.285771	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.409302	6.74e-21
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.314837	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.272979	2.17e-34
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.627404	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.330441	1.84e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.266634	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.385748	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.572778	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.306867	1.02e-08
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.280743	0.00e+00

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Expression of AMD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AMD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AMD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AMD1	hsa-miR-4753-3p	98.522	NM_001287214
AMD1	hsa-miR-4698	98.435	NM_001287214
AMD1	hsa-miR-9902	97.1665	NM_001287214
AMD1	hsa-miR-130a-5p	96.7507	NM_001287214
AMD1	hsa-miR-6508-5p	96.3732	NM_001287214
AMD1	hsa-miR-5689	94.5549	NM_001287214
AMD1	hsa-miR-8067	94.3549	NM_001287214
AMD1	hsa-miR-876-3p	93.8722	NM_001287214
AMD1	hsa-miR-4531	93.2428	NM_001287214
AMD1	hsa-miR-6809-3p	92.3857	NM_001287214
AMD1	hsa-miR-186-5p	92.1374	NM_001287214
AMD1	hsa-miR-1305	91.5858	NM_001287214
AMD1	hsa-miR-4729	91.4108	NM_001287214
AMD1	hsa-miR-6715a-3p	90.7685	NM_001287214
AMD1	hsa-miR-1250-3p	90.7085	NM_001287214
AMD1	hsa-miR-323a-5p	90.2333	NM_001287214
AMD1	hsa-miR-5700	89.9485	NM_001287214
AMD1	hsa-miR-6868-5p	89.7577	NM_001287214
AMD1	hsa-miR-7155-5p	89.748	NM_001287214
AMD1	hsa-miR-4536-5p	89.5962	NM_001287214
AMD1	hsa-miR-497-3p	89.5505	NM_001287214
AMD1	hsa-miR-432-5p	89.4526	NM_001287214
AMD1	hsa-miR-3977	88.882	NM_001287214
AMD1	hsa-miR-4773	88.8128	NM_001287214
AMD1	hsa-miR-4760-5p	88.7273	NM_001287214
AMD1	hsa-miR-6071	88.4302	NM_001287214
AMD1	hsa-miR-7850-5p	87.9256	NM_001287214
AMD1	hsa-miR-216a-3p	87.9073	NM_001287214
AMD1	hsa-miR-128-3p	87.9073	NM_001287214
AMD1	hsa-miR-5696	87.8682	NM_001287214
AMD1	hsa-miR-137-3p	87.5954	NM_001287214
AMD1	hsa-miR-645	87.5434	NM_001287214
AMD1	hsa-miR-8063	87.5258	NM_001287214
AMD1	hsa-miR-3681-3p	87.4923	NM_001287214
AMD1	hsa-miR-4646-3p	87.2167	NM_001287214
AMD1	hsa-miR-3163	87.033	NM_001287214
AMD1	hsa-miR-125b-2-3p	86.5356	NM_001287214
AMD1	hsa-miR-150-3p	86.3197	NM_001287214
AMD1	hsa-miR-134-3p	86.0447	NM_001287214
AMD1	hsa-miR-3928-3p	85.8071	NM_001287214
AMD1	hsa-miR-3671	85.6782	NM_001287214
AMD1	hsa-miR-4261	85.6341	NM_001287214
AMD1	hsa-miR-491-5p	85.1306	NM_001287214
AMD1	hsa-miR-890	84.4178	NM_001287214
AMD1	hsa-miR-224-5p	84.3455	NM_001287214
AMD1	hsa-miR-584-3p	84.2591	NM_001287214
AMD1	hsa-miR-212-3p	84.1565	NM_001287214
AMD1	hsa-miR-132-3p	84.1565	NM_001287214
AMD1	hsa-miR-5697	83.5329	NM_001287214
AMD1	hsa-miR-27b-3p	83.1364	NM_001287214

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Motifs and transcription factors (TFs) regulating AMD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AMD1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
AMD1	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
AMD1	metacluster_182.10	ZFX (directAnnotation).
AMD1	transfac_pro__M00492	STAT1 (directAnnotation).
AMD1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
AMD1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
AMD1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
AMD1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
AMD1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
AMD1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
AMD1	cisbp__M00788	ZFY (inferredBy_Orthology).
AMD1	transfac_pro__M00430	E2F1 (directAnnotation).
AMD1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
AMD1	transfac_pro__M04893	TAF1 (directAnnotation).
AMD1	transfac_pro__M01199	TRIM28 (directAnnotation).
AMD1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AMD1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
AMD1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
AMD1	hdpi__HIP2	UBE2K (directAnnotation).
AMD1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
AMD1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
AMD1	metacluster_191.5	SPDEF (inferredBy_Orthology).
AMD1	transfac_pro__M00938	E2F1 (directAnnotation).
AMD1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
AMD1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
AMD1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
AMD1	hdpi__RARA	RARA (directAnnotation).
AMD1	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
AMD1	jaspar__MA1583.1	ZFP57 (directAnnotation).
AMD1	transfac_pro__M02898	SMAD3 (directAnnotation).
AMD1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
AMD1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
AMD1	jaspar__MA1721.1	ZNF93 (directAnnotation).
AMD1	transfac_pro__M04916	TAF1 (directAnnotation).
AMD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
AMD1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
AMD1	transfac_pro__M07310	SP5 (directAnnotation).
AMD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
AMD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
AMD1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
AMD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AMD1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
AMD1	cisbp__M00249	WT1 (directAnnotation).
AMD1	hdpi__ZNF304	ZNF304 (directAnnotation).
AMD1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
AMD1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
AMD1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
AMD1	transfac_pro__M07483	CXXC1 (directAnnotation).
AMD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
AMD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AMD1	"5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine"	DB08163	small molecule
AMD1	"Ademetionine"	DB00118	small molecule
AMD1	"Putrescine"	DB01917	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."