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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AKAP12

Summary for AKAP12

Gene information	Gene symbol	AKAP12
	Ensembl ID	ENSG00000131016
	Entrez ID	9590
	Gene name	A-kinase anchoring protein 12
	Synonyms	AKAP250\|SSeCKS
	Gene type	protein_coding
	UniProtAcc	Q02952

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Dataset with differentially expressed gene: AKAP12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.33933	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.639337	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.469616	5.71e-27
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.748626	1.34e-40
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.490281	8.42e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.375368	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.01401	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.875314	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.637144	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.262673	0.00e+00

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Expression of AKAP12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AKAP12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
AKAP12	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating AKAP12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKAP12	hsa-miR-190a-3p	99.6342	NM_144497
AKAP12	hsa-miR-5011-5p	97.1937	NM_144497
AKAP12	hsa-miR-3925-3p	96.1412	NM_005100
AKAP12	hsa-miR-508-5p	95.8607	NM_005100
AKAP12	hsa-miR-4666a-3p	93.9489	NM_005100
AKAP12	hsa-miR-2116-5p	93.4933	NM_144497
AKAP12	hsa-miR-4677-5p	92.5524	NM_144497
AKAP12	hsa-miR-590-5p	92.539	NM_005100
AKAP12	hsa-let-7b-3p	92.3765	NM_005100
AKAP12	hsa-let-7a-3p	92.3765	NM_005100
AKAP12	hsa-let-7f-1-3p	92.3765	NM_005100
AKAP12	hsa-miR-98-3p	92.3765	NM_005100
AKAP12	hsa-miR-21-5p	92.2884	NM_005100
AKAP12	hsa-miR-5580-3p	91.8861	NM_005100
AKAP12	hsa-miR-3160-5p	91.591	NM_144497
AKAP12	hsa-miR-495-3p	91.3966	NM_144497
AKAP12	hsa-miR-381-3p	90.7524	NM_005100
AKAP12	hsa-miR-300	90.7524	NM_005100
AKAP12	hsa-miR-5688	90.6801	NM_144497
AKAP12	hsa-miR-338-3p	89.7696	NM_144497
AKAP12	hsa-miR-4698	89.0827	NM_005100
AKAP12	hsa-miR-183-5p	88.951	NM_144497
AKAP12	hsa-miR-6720-5p	88.7499	NM_005100
AKAP12	hsa-miR-6512-3p	88.7499	NM_005100
AKAP12	hsa-miR-942-3p	87.1715	NM_005100
AKAP12	hsa-miR-23c	87.0336	NM_005100
AKAP12	hsa-miR-23a-3p	87.0336	NM_005100
AKAP12	hsa-miR-23b-3p	87.0336	NM_005100
AKAP12	hsa-miR-646	85.9614	NM_005100
AKAP12	hsa-miR-3664-3p	85.2238	NM_005100
AKAP12	hsa-miR-22-5p	84.7249	NM_144497
AKAP12	hsa-miR-3606-5p	83.4976	NM_144497
AKAP12	hsa-miR-6822-3p	83.366	NM_144497
AKAP12	hsa-miR-5195-3p	83.0999	NM_005100
AKAP12	hsa-miR-145-5p	83.0999	NM_005100
AKAP12	hsa-miR-8064	82.5318	NM_144497
AKAP12	hsa-miR-760	82.5317	NM_144497
AKAP12	hsa-miR-4328	82.2482	NM_144497
AKAP12	hsa-miR-548s	82.2136	NM_144497
AKAP12	hsa-miR-1250-3p	82.0997	NM_005100
AKAP12	hsa-miR-659-5p	80.7533	NM_144497
AKAP12	hsa-miR-4772-5p	80.6774	NM_144497
AKAP12	hsa-miR-302f	80.4949	NM_144497
AKAP12	hsa-miR-10527-5p	80.3847	NM_144497
AKAP12	hsa-miR-4760-5p	80.3155	NM_144497
AKAP12	hsa-miR-8061	80.0156	NM_144497

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Motifs and transcription factors (TFs) regulating AKAP12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKAP12	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
AKAP12	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
AKAP12	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
AKAP12	cisbp__M02645	ETS1 (directAnnotation).
AKAP12	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
AKAP12	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
AKAP12	hdpi__ELF2	ELF2 (directAnnotation).
AKAP12	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
AKAP12	swissregulon__hs__ELK1	ELK1 (directAnnotation).
AKAP12	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
AKAP12	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AKAP12	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
AKAP12	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
AKAP12	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
AKAP12	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
AKAP12	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
AKAP12	cisbp__M00808	MYPOP (inferredBy_Orthology).
AKAP12	metacluster_22.34	BACH2 (directAnnotation).
AKAP12	metacluster_74.23	HNF1B (inferredBy_Orthology).
AKAP12	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
AKAP12	metacluster_22.37	BACH1 (directAnnotation).
AKAP12	metacluster_22.13	MAFK (inferredBy_Orthology).
AKAP12	metacluster_22.18	BACH2 (inferredBy_Orthology).
AKAP12	transfac_pro__M06181	ZNF165 (directAnnotation).
AKAP12	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
AKAP12	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
AKAP12	metacluster_22.32	NFE2L2 (directAnnotation).
AKAP12	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."