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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AGO2

Summary for AGO2

Gene information	Gene symbol	AGO2
	Ensembl ID	ENSG00000123908
	Entrez ID	27161
	Gene name	argonaute RISC catalytic component 2
	Synonyms	CASC7\|EIF2C2\|hAGO2\|LINC00980\|Q10
	Gene type	protein_coding
	UniProtAcc	Q9UKV8

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Dataset with differentially expressed gene: AGO2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.306758	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.453601	0.00e+00

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Expression of AGO2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AGO2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AGO2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AGO2	hsa-miR-376a-3p	97.703	NM_001164623
AGO2	hsa-miR-376b-3p	97.703	NM_001164623
AGO2	hsa-miR-4463	97.3375	NM_001164623
AGO2	hsa-miR-151a-3p	94.5644	NM_001164623
AGO2	hsa-miR-548aj-3p	92.301	NM_001164623
AGO2	hsa-miR-548x-3p	92.301	NM_001164623
AGO2	hsa-miR-548aq-3p	90.3658	NM_001164623
AGO2	hsa-miR-548am-3p	90.3658	NM_001164623
AGO2	hsa-miR-548ah-3p	90.3658	NM_001164623
AGO2	hsa-miR-548j-3p	90.3658	NM_001164623
AGO2	hsa-miR-548ae-3p	90.3658	NM_001164623
AGO2	hsa-miR-875-3p	90.1311	NM_001164623
AGO2	hsa-miR-8063	89.2479	NM_001164623
AGO2	hsa-miR-1910-5p	89.0977	NM_001164623
AGO2	hsa-miR-92b-5p	88.7076	NM_001164623
AGO2	hsa-miR-1299	87.9087	NM_001164623
AGO2	hsa-miR-5580-5p	87.581	NM_001164623
AGO2	hsa-miR-12122	87.3277	NM_001164623
AGO2	hsa-miR-6503-5p	87.3224	NM_001164623
AGO2	hsa-miR-646	87.1586	NM_001164623
AGO2	hsa-miR-548aa	87.1553	NM_001164623
AGO2	hsa-miR-548ap-3p	87.1553	NM_001164623
AGO2	hsa-miR-548t-3p	87.1553	NM_001164623
AGO2	hsa-miR-4527	86.5938	NM_001164623
AGO2	hsa-miR-4502	85.7854	NM_001164623
AGO2	hsa-miR-6715a-3p	83.923	NM_001164623
AGO2	hsa-miR-4639-3p	82.9574	NM_001164623

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Motifs and transcription factors (TFs) regulating AGO2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AGO2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
AGO2	transfac_pro__M05479	ZNF580 (directAnnotation).
AGO2	jaspar__MA1122.1	TFDP1 (directAnnotation).
AGO2	cisbp__M00341	PAX6 (directAnnotation).
AGO2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
AGO2	tfdimers__MD00151	CHURC1 (directAnnotation).
AGO2	tfdimers__MD00391	KLF4 (directAnnotation).
AGO2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
AGO2	metacluster_3.14	WT1; WT1 (directAnnotation).
AGO2	transfac_public__M00491	PATZ1 (directAnnotation).
AGO2	transfac_pro__M07397	ZNF148 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."