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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ADK

Summary for ADK

Gene information	Gene symbol	ADK
	Ensembl ID	ENSG00000156110
	Entrez ID	132
	Gene name	adenosine kinase
	Synonyms	AK
	Gene type	protein_coding
	UniProtAcc	P55263

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Dataset with differentially expressed gene: ADK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.312894	1.03e-13
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.272739	1.94e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.936467	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.29063	1.12e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.45095	3.39e-29
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.404377	1.40e-17

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Expression of ADK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADK	hsa-miR-96-5p	95.1959	NM_001123
ADK	hsa-miR-12133	94.0428	NM_001123
ADK	hsa-miR-1271-5p	94.0428	NM_001123
ADK	hsa-miR-6875-3p	93.8657	NM_001123
ADK	hsa-miR-3934-5p	93.2897	NM_001123
ADK	hsa-miR-4659a-3p	93.1011	NM_001123
ADK	hsa-miR-4659b-3p	93.1011	NM_001123
ADK	hsa-miR-7157-5p	91.7682	NM_001123
ADK	hsa-miR-4310	91.3635	NM_001123
ADK	hsa-miR-520d-5p	90.5107	NM_001123
ADK	hsa-miR-524-5p	90.5107	NM_001123
ADK	hsa-miR-153-5p	88.196	NM_001123
ADK	hsa-miR-3646	86.9367	NM_001123
ADK	hsa-miR-3664-3p	85.106	NM_001123
ADK	hsa-miR-4666a-5p	84.7729	NM_001123
ADK	hsa-miR-12136	84.4258	NM_001123
ADK	hsa-miR-3973	84.247	NM_001123
ADK	hsa-miR-568	83.3467	NM_001123
ADK	hsa-miR-330-3p	82.9807	NM_001123
ADK	hsa-miR-939-3p	82.257	NM_001123
ADK	hsa-miR-203a-3p	80.8105	NM_001123

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Motifs and transcription factors (TFs) regulating ADK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADK	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ADK	transfac_pro__M02089	E2F3 (directAnnotation).
ADK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ADK	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ADK	"5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE"	DB07280	small molecule
ADK	"7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE"	DB07173	small molecule
ADK	"Adenosine phosphate"	DB00131	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."