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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADD1

Summary for ADD1

Gene information	Gene symbol	ADD1
	Ensembl ID	ENSG00000087274
	Entrez ID	118
	Gene name	adducin 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ADD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.641125	5.80e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.260615	2.31e-15
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.291902	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-1.03797	1.24e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.73245	5.06e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.297324	0.00e+00

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Expression of ADD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADD1	hsa-miR-3609	98.3335	NM_001286645
ADD1	hsa-miR-548ah-5p	98.3335	NM_001286645
ADD1	hsa-miR-4778-3p	98.199	NM_001286645
ADD1	hsa-miR-1283	95.8616	NM_001286645
ADD1	hsa-miR-6742-5p	95.777	NM_001119
ADD1	hsa-miR-758-3p	94.3003	NM_001286645
ADD1	hsa-miR-1912-5p	94.2919	NM_001286645
ADD1	hsa-miR-6797-5p	93.0637	NM_001119
ADD1	hsa-miR-1249-5p	93.0637	NM_001119
ADD1	hsa-miR-616-3p	91.6382	NM_001286645
ADD1	hsa-miR-885-5p	91.5624	NM_001286645
ADD1	hsa-miR-6720-5p	91.0432	NM_001119
ADD1	hsa-miR-6512-3p	91.0432	NM_001119
ADD1	hsa-miR-448	90.2165	NM_001286645
ADD1	hsa-miR-655-3p	89.8475	NM_001286645
ADD1	hsa-miR-374c-5p	89.8475	NM_001286645
ADD1	hsa-miR-196a-3p	89.3811	NM_001286645
ADD1	hsa-miR-548t-5p	88.8053	NM_001286645
ADD1	hsa-miR-548az-5p	88.8053	NM_001286645
ADD1	hsa-miR-5193	88.5959	NM_001286645
ADD1	hsa-miR-299-3p	87.9147	NM_001119
ADD1	hsa-miR-3151-5p	85.7292	NM_001286645
ADD1	hsa-miR-4447	85.7125	NM_001119
ADD1	hsa-miR-4779	84.0073	NM_001119
ADD1	hsa-miR-660-3p	83.3687	NM_001286645
ADD1	hsa-miR-590-3p	83.1844	NM_001286645
ADD1	hsa-miR-4317	82.5324	NM_001286645
ADD1	hsa-miR-6757-3p	82.4009	NM_001119
ADD1	hsa-miR-6504-5p	82.2832	NM_001119
ADD1	hsa-miR-3085-3p	82.2832	NM_001119
ADD1	hsa-miR-3064-5p	82.2832	NM_001119

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Motifs and transcription factors (TFs) regulating ADD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADD1	transfac_pro__M04916	TAF1 (directAnnotation).
ADD1	transfac_pro__M02089	E2F3 (directAnnotation).
ADD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
ADD1	transfac_pro__M07310	SP5 (directAnnotation).
ADD1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ADD1	hdpi__NRL	NRL (directAnnotation).
ADD1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ADD1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ADD1	transfac_pro__M01783	SP2 (directAnnotation).
ADD1	cisbp__M07938	E2F1 (directAnnotation).
ADD1	tfdimers__MD00483	ZBTB14 (directAnnotation).
ADD1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADD1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
ADD1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ADD1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
ADD1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ADD1	hdpi__ZNF304	ZNF304 (directAnnotation).
ADD1	cisbp__M00788	ZFY (inferredBy_Orthology).
ADD1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADD1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADD1	cisbp__M00343	PAX6 (directAnnotation).
ADD1	transfac_pro__M00938	E2F1 (directAnnotation).
ADD1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
ADD1	transfac_pro__M12694	ZFP14 (directAnnotation).
ADD1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
ADD1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."