Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAR

Summary for ADAR

Gene information	Gene symbol	ADAR
	Ensembl ID	ENSG00000160710
	Entrez ID	103
	Gene name	adenosine deaminase RNA specific
	Synonyms	ADAR1\|DRADA\|G1P1\|IFI4
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: ADAR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.431891	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.429985	1.47e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.250601	1.48e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.327699	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.311789	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.338569	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.455383	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.345756	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.379292	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.254571	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.263361	5.35e-03
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.309157	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.40013	5.78e-16
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.357712	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.286479	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.270293	1.02e-24
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.648242	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.408987	0.00e+00

Top

Expression of ADAR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ADAR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ADAR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAR	hsa-miR-4428	97.6335	NM_015840
ADAR	hsa-miR-432-5p	97.1374	NM_001025107
ADAR	hsa-miR-1-3p	95.8092	NM_001025107
ADAR	hsa-miR-613	95.8092	NM_001025107
ADAR	hsa-miR-206	95.8092	NM_001025107
ADAR	hsa-miR-5100	93.0907	NM_015840
ADAR	hsa-miR-4309	91.9354	NM_001025107
ADAR	hsa-miR-3198	91.9354	NM_001025107
ADAR	hsa-miR-1275	91.8264	NM_001025107
ADAR	hsa-miR-186-3p	90.4433	NM_015840
ADAR	hsa-miR-651-3p	90.1495	NM_001025107
ADAR	hsa-miR-135b-5p	89.7383	NM_015840
ADAR	hsa-miR-135a-5p	89.7383	NM_015840
ADAR	hsa-miR-6760-3p	88.6168	NM_015840
ADAR	hsa-miR-3928-3p	88.2156	NM_001025107
ADAR	hsa-miR-548e-5p	87.9371	NM_015840
ADAR	hsa-miR-6803-5p	87.5198	NM_001025107
ADAR	hsa-miR-10394-5p	87.1364	NM_001025107
ADAR	hsa-miR-1205	87.1364	NM_001025107
ADAR	hsa-miR-625-5p	86.7662	NM_015840
ADAR	hsa-miR-4732-3p	86.651	NM_015840
ADAR	hsa-miR-3137	84.7106	NM_015840
ADAR	hsa-miR-1229-5p	83.921	NM_015840
ADAR	hsa-miR-4530	83.8035	NM_001025107
ADAR	hsa-miR-892c-5p	83.3625	NM_001025107
ADAR	hsa-miR-3915	83.2786	NM_001025107
ADAR	hsa-miR-4261	82.8856	NM_001025107
ADAR	hsa-miR-423-5p	82.724	NM_015840
ADAR	hsa-miR-3184-5p	82.724	NM_015840
ADAR	hsa-miR-4665-5p	82.5178	NM_001025107
ADAR	hsa-miR-6751-5p	82.2158	NM_001025107
ADAR	hsa-miR-4457	82.0632	NM_015840
ADAR	hsa-miR-2114-5p	81.144	NM_015840
ADAR	hsa-miR-6791-5p	80.6616	NM_015840
ADAR	hsa-miR-4292	80.6616	NM_015840

Page: 1

Top

Motifs and transcription factors (TFs) regulating ADAR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAR	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ADAR	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ADAR	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
ADAR	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
ADAR	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
ADAR	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ADAR	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSNNNNCRMN_CAP	E2F3; TBX21 (directAnnotation).
ADAR	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ADAR	cisbp__M00249	WT1 (directAnnotation).
ADAR	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
ADAR	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
ADAR	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ADAR	transfac_public__M00373	PAX4 (directAnnotation).
ADAR	transfac_pro__M00938	E2F1 (directAnnotation).
ADAR	transfac_pro__M12667	GPBP1L1 (directAnnotation).
ADAR	cisbp__M00341	PAX6 (directAnnotation).
ADAR	metacluster_159.3	ARID3A; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; HMGXB4; KLF16; MBD1; RAD21; RAD21; RAD21; RXRA; SMC3; SMC3; ZNF576; ZNF654; ZNF764 (directAnnotation). CTCF; CTCF; CTCF; CTCF; CTCFL (inferredBy_Orthology).
ADAR	transfac_pro__M08818	KLF8 (directAnnotation).
ADAR	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
ADAR	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
ADAR	transfac_pro__M04887	TCF12 (directAnnotation).
ADAR	taipale_cyt_meth__LMX1B_YTCGTTAW_eDBD_meth	LMX1B (directAnnotation).
ADAR	kznf__ZNF442_Imbeault2017_RP_RCADE	ZNF442 (directAnnotation).
ADAR	kznf__ZNF485_Imbeault2017_RP_RCADE	ZNF485 (directAnnotation).
ADAR	transfac_pro__M05379	ZNF740 (inferredBy_Orthology).
ADAR	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
ADAR	metacluster_22.33	MAFK (inferredBy_Orthology).
ADAR	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
ADAR	metacluster_22.32	NFE2L2 (directAnnotation).
ADAR	metacluster_22.37	BACH1 (directAnnotation).
ADAR	metacluster_22.1	MAFF (inferredBy_Orthology).
ADAR	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
ADAR	metacluster_22.19	NFE2 (directAnnotation).
ADAR	metacluster_22.36	BACH2 (directAnnotation).
ADAR	tfdimers__MD00591	SRY; TFAP2C (directAnnotation).
ADAR	metacluster_22.20	MAFG (directAnnotation).
ADAR	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ADAR	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ADAR	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ADAR	cisbp__M00788	ZFY (inferredBy_Orthology).
ADAR	transfac_pro__M00430	E2F1 (directAnnotation).
ADAR	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ADAR	hdpi__TP73	TP73 (directAnnotation).
ADAR	hdpi__HIP2	UBE2K (directAnnotation).
ADAR	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ADAR	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ADAR	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ADAR	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
ADAR	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ADAR	hdpi__RARA	RARA (directAnnotation).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."