Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | NK cells | 0.379318 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD4+ T cells | 0.31279 | 0.00e+00 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD4+ T cells | 0.37652 | 1.97e-40 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD8+ T cells | 0.315881 | 0.00e+00 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | -0.275883 | 0.00e+00 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | post | Malignant cells | 0.382248 | 1.17e-12 |
GSE168668 | LNCaP cell line | Cell line | Prostate cancer | Prostate cancer | Targeted therapy | enzalutamide | NA | Malignant cells | -0.257836 | 0.00e+00 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | 0.260938 | 8.13e-10 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | 0.283117 | 7.52e-40 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -0.521325 | 2.80e-45 |
Gene symbol | motif | TF_highConf |
ADAM10 | metacluster_151.2 | ZNF23 (directAnnotation). |
ADAM10 | transfac_public__M00189 | TFAP2A; TFAP2B; TFAP2C (directAnnotation). |
ADAM10 | transfac_pro__M01219 | SP1 (directAnnotation). SP3 (inferredBy_Orthology). |
ADAM10 | transfac_pro__M03806 | ZBTB7C (directAnnotation). |
ADAM10 | transfac_pro__M00915 | TFAP2A; TFAP2B; TFAP2C (directAnnotation). |
ADAM10 | jaspar__MA0079.5 | SP1 (directAnnotation). |
ADAM10 | kznf__KLF1_Barrera2016.2_PBM | KLF1 (directAnnotation). |
ADAM10 | taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr | ZNF460 (directAnnotation). |
ADAM10 | transfac_pro__M01253 | CNOT3 (directAnnotation). |
ADAM10 | transfac_pro__M04817 | ZBTB33 (directAnnotation). |
ADAM10 | swissregulon__hs__ZBTB14 | ZBTB14 (directAnnotation). |
ADAM10 | taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr | E2F2 (directAnnotation). |
ADAM10 | cisbp__M07938 | E2F1 (directAnnotation). |
ADAM10 | kznf__ZBTB14_Schmitges2016_RCADE | ZBTB14 (directAnnotation). |
ADAM10 | taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP | E2F3; HES7 (directAnnotation). |
ADAM10 | transfac_pro__M02089 | E2F3 (directAnnotation). |
ADAM10 | taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth | E2F2 (directAnnotation). |
ADAM10 | transfac_pro__M00803 | E2F1; E2F3; E2F4; TFDP1 (directAnnotation). |
ADAM10 | metacluster_143.13 | ZBTB7A (directAnnotation). |
ADAM10 | transfac_pro__M02861 | GATA6 (inferredBy_Orthology). |
ADAM10 | tfdimers__MD00483 | ZBTB14 (directAnnotation). |
ADAM10 | jaspar__MA0535.1 | SMAD9 (inferredBy_Orthology). |
ADAM10 | metacluster_15.1 | E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology). |
ADAM10 | metacluster_15.2 | E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology). |
ADAM10 | taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr | E2F1; HES7 (directAnnotation). |
ADAM10 | jaspar__MA1122.1 | TFDP1 (directAnnotation). |
ADAM10 | taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP | ETV5; HES7 (directAnnotation). |
ADAM10 | flyfactorsurvey__Mad_FlyReg_FBgn0011648 | SMAD9 (inferredBy_Orthology). |
ADAM10 | hdpi__NRL | NRL (directAnnotation). |
ADAM10 | transfac_pro__M07310 | SP5 (directAnnotation). |
ADAM10 | transfac_pro__M02933 | ZBTB14 (inferredBy_Orthology). |
ADAM10 | metacluster_67.2 | ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology). |
ADAM10 | transfac_pro__M07317 | CTBP1 (directAnnotation). |
ADAM10 | transfac_pro__M12697 | ZNF142 (directAnnotation). |
ADAM10 | transfac_pro__M00716 | ZBTB14 (directAnnotation). |
ADAM10 | taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr | E2F8; TFAP2C (directAnnotation). |
ADAM10 | transfac_pro__M01090 | SMAD9 (inferredBy_Orthology). |
ADAM10 | transfac_pro__M04893 | TAF1 (directAnnotation). |
ADAM10 | transfac_pro__M01783 | SP2 (directAnnotation). |
ADAM10 | transfac_pro__M04916 | TAF1 (directAnnotation). |
ADAM10 | kznf__ZNF548_Imbeault2017_RP_RCADE | ZNF548 (directAnnotation). |
ADAM10 | idmmpmm__Mad | SMAD9 (inferredBy_Orthology). |
ADAM10 | hdpi__RARA | RARA (directAnnotation). |
ADAM10 | hdpi__HTATIP2 | HTATIP2 (directAnnotation). |
ADAM10 | jaspar__MA1650.1 | ZBTB14 (directAnnotation). |
ADAM10 | taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr | E2F1; ELK1 (directAnnotation). |
ADAM10 | hdpi__HIP2 | UBE2K (directAnnotation). |
ADAM10 | transfac_pro__M01240 | GTF2IRD1 (directAnnotation). |
ADAM10 | dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1 | ZBTB8A (directAnnotation). |
ADAM10 | cisbp__M08228 | PAX5 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |