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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABLIM1

Summary for ABLIM1

Gene information	Gene symbol	ABLIM1
	Ensembl ID	ENSG00000099204
	Entrez ID	3983
	Gene name	actin binding LIM protein 1
	Synonyms	ABLIM\|LIMAB1\|limatin
	Gene type	protein_coding
	UniProtAcc	O14639

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Dataset with differentially expressed gene: ABLIM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.465962	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.321844	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.281121	2.79e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.399498	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.250979	9.22e-03
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.456244	0.00e+00

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Expression of ABLIM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABLIM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABLIM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABLIM1	hsa-miR-8485	99.9987	NM_001003407
ABLIM1	hsa-miR-6885-3p	99.2069	NM_001322893
ABLIM1	hsa-miR-4659b-3p	98.6018	NM_001322893
ABLIM1	hsa-miR-4659a-3p	98.6018	NM_001322893
ABLIM1	hsa-miR-6776-5p	98.544	NM_001003407
ABLIM1	hsa-miR-4753-3p	98.4824	NM_001322893
ABLIM1	hsa-miR-3678-3p	98.4614	NM_001322893
ABLIM1	hsa-miR-3138	98.412	NM_001003407
ABLIM1	hsa-miR-130a-5p	97.4126	NM_001322893
ABLIM1	hsa-miR-7161-5p	96.1615	NM_001003407
ABLIM1	hsa-miR-548u	96.1615	NM_001003407
ABLIM1	hsa-miR-6809-3p	95.2441	NM_001322893
ABLIM1	hsa-miR-2467-3p	94.0487	NM_001322893
ABLIM1	hsa-miR-6124	91.0132	NM_001003407
ABLIM1	hsa-miR-3977	90.3376	NM_001322893
ABLIM1	hsa-miR-4422	90.0883	NM_001003407
ABLIM1	hsa-miR-6868-3p	89.5967	NM_001322893
ABLIM1	hsa-miR-590-3p	88.8119	NM_001322893
ABLIM1	hsa-miR-4775	87.8353	NM_001322893
ABLIM1	hsa-miR-548g-5p	85.7613	NM_001003407
ABLIM1	hsa-miR-548x-5p	85.7613	NM_001003407
ABLIM1	hsa-miR-548f-5p	85.7613	NM_001003407
ABLIM1	hsa-miR-548aj-5p	85.7613	NM_001003407
ABLIM1	hsa-miR-548aw	85.598	NM_001003407
ABLIM1	hsa-miR-130b-5p	84.119	NM_001322893
ABLIM1	hsa-miR-3972	83.7668	NM_001003407
ABLIM1	hsa-miR-1202	83.6706	NM_001003407
ABLIM1	hsa-miR-514b-5p	83.36	NM_001322893
ABLIM1	hsa-miR-513c-5p	83.36	NM_001322893
ABLIM1	hsa-miR-4531	82.6372	NM_001322893
ABLIM1	hsa-miR-450a-1-3p	82.3391	NM_001322893
ABLIM1	hsa-miR-548e-5p	80.9626	NM_001003407
ABLIM1	hsa-miR-3133	80.9086	NM_001003407
ABLIM1	hsa-miR-4328	80.6808	NM_001322893
ABLIM1	hsa-miR-12131	80.2319	NM_001322893
ABLIM1	hsa-miR-129-1-3p	80.1198	NM_001003407
ABLIM1	hsa-miR-129-2-3p	80.1198	NM_001003407

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Motifs and transcription factors (TFs) regulating ABLIM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABLIM1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ABLIM1	hdpi__HIP2	UBE2K (directAnnotation).
ABLIM1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
ABLIM1	hdpi__ZNF304	ZNF304 (directAnnotation).
ABLIM1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ABLIM1	cisbp__M08228	PAX5 (directAnnotation).
ABLIM1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ABLIM1	transfac_pro__M00938	E2F1 (directAnnotation).
ABLIM1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ABLIM1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
ABLIM1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ABLIM1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
ABLIM1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ABLIM1	cisbp__M00788	ZFY (inferredBy_Orthology).
ABLIM1	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
ABLIM1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ABLIM1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
ABLIM1	transfac_pro__M02090	E2F4 (directAnnotation).
ABLIM1	transfac_pro__M03846	SMAD5 (directAnnotation).
ABLIM1	metacluster_45.4	E2F2 (directAnnotation).
ABLIM1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ABLIM1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ABLIM1	metacluster_175.1	ZNF283 (directAnnotation).
ABLIM1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ABLIM1	metacluster_7.13	ZFX (directAnnotation).
ABLIM1	hdpi__FEZF2	FEZF2 (directAnnotation).
ABLIM1	cisbp__M00343	PAX6 (directAnnotation).
ABLIM1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ABLIM1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ABLIM1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ABLIM1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ABLIM1	transfac_pro__M01199	TRIM28 (directAnnotation).
ABLIM1	transfac_pro__M12694	ZFP14 (directAnnotation).
ABLIM1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ABLIM1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ABLIM1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
ABLIM1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ABLIM1	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
ABLIM1	cisbp__M00341	PAX6 (directAnnotation).
ABLIM1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ABLIM1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ABLIM1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ABLIM1	transfac_pro__M02898	SMAD3 (directAnnotation).
ABLIM1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ABLIM1	transfac_pro__M07387	ZBTB7A (directAnnotation).
ABLIM1	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
ABLIM1	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
ABLIM1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ABLIM1	transfac_pro__M09837	ZNF449 (directAnnotation).
ABLIM1	transfac_pro__M00430	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."