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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABI2

Summary for ABI2

Gene information	Gene symbol	ABI2
	Ensembl ID	ENSG00000138443
	Entrez ID	10152
	Gene name	abl interactor 2
	Synonyms	ABI-2\|ABI2B\|AblBP3\|AIP-1\|argBPIA\|SSH3BP2
	Gene type	protein_coding
	UniProtAcc	Q9NYB9

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Dataset with differentially expressed gene: ABI2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.403525	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.308857	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.389297	9.24e-24
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.385081	0.00e+00

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Expression of ABI2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABI2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABI2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABI2	hsa-miR-193a-3p	95.5648	NM_001282925
ABI2	hsa-miR-193b-3p	94.5401	NM_001282925
ABI2	hsa-miR-1200	92.3527	NM_001282925
ABI2	hsa-miR-6778-3p	91.059	NM_001282925
ABI2	hsa-miR-877-3p	90.94	NM_001282925
ABI2	hsa-miR-4654	88.7784	NM_001282925
ABI2	hsa-miR-3658	88.6568	NM_001282925
ABI2	hsa-miR-4668-5p	88.0079	NM_001282925
ABI2	hsa-miR-495-5p	87.9437	NM_001282925
ABI2	hsa-miR-12117	86.6681	NM_001282925
ABI2	hsa-miR-8066	86.6452	NM_001282925
ABI2	hsa-miR-34b-3p	86.3283	NM_001282925
ABI2	hsa-miR-4769-5p	86.2715	NM_001282925
ABI2	hsa-miR-6726-5p	86.2333	NM_001282925
ABI2	hsa-miR-920	86.2333	NM_001282925
ABI2	hsa-miR-625-5p	85.6682	NM_001282925
ABI2	hsa-miR-4471	85.6589	NM_001282925
ABI2	hsa-miR-5591-5p	85.5998	NM_001282925
ABI2	hsa-miR-4300	85.5998	NM_001282925
ABI2	hsa-miR-548d-3p	85.0107	NM_001282925
ABI2	hsa-miR-548ac	85.0107	NM_001282925
ABI2	hsa-miR-548bb-3p	85.0107	NM_001282925
ABI2	hsa-miR-548z	85.0107	NM_001282925
ABI2	hsa-miR-548h-3p	85.0107	NM_001282925
ABI2	hsa-let-7c-3p	84.6614	NM_001282925
ABI2	hsa-miR-548aa	83.6645	NM_001282925
ABI2	hsa-miR-548t-3p	83.6645	NM_001282925
ABI2	hsa-miR-548ap-3p	83.6645	NM_001282925
ABI2	hsa-miR-183-5p	82.449	NM_001282925
ABI2	hsa-miR-664b-3p	82.3792	NM_001282925
ABI2	hsa-miR-579-3p	82.3792	NM_001282925
ABI2	hsa-miR-1205	81.9695	NM_001282925
ABI2	hsa-miR-10394-5p	81.9695	NM_001282925
ABI2	hsa-miR-153-5p	81.7469	NM_001282925
ABI2	hsa-miR-8059	81.6061	NM_001282925
ABI2	hsa-miR-1236-3p	81.4289	NM_001282925
ABI2	hsa-miR-664a-3p	80.1849	NM_001282925
ABI2	hsa-miR-331-3p	80.0422	NM_001282925

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Motifs and transcription factors (TFs) regulating ABI2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABI2	transfac_pro__M02898	SMAD3 (directAnnotation).
ABI2	transfac_public__M00491	PATZ1 (directAnnotation).
ABI2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ABI2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ABI2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ABI2	cisbp__M00249	WT1 (directAnnotation).
ABI2	transfac_pro__M01122	ZNF219 (directAnnotation).
ABI2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ABI2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ABI2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ABI2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ABI2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ABI2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
ABI2	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
ABI2	metacluster_84.2	RARA (directAnnotation).
ABI2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ABI2	transfac_pro__M01253	CNOT3 (directAnnotation).
ABI2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ABI2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
ABI2	jaspar__MA1721.1	ZNF93 (directAnnotation).
ABI2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ABI2	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
ABI2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ABI2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ABI2	cisbp__M00341	PAX6 (directAnnotation).
ABI2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ABI2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
ABI2	transfac_pro__M01199	TRIM28 (directAnnotation).
ABI2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
ABI2	tfdimers__MD00391	KLF4 (directAnnotation).
ABI2	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
ABI2	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
ABI2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ABI2	cisbp__M00968	MTF2 (directAnnotation).
ABI2	transfac_pro__M01973	PLAG1 (directAnnotation).
ABI2	transfac_pro__M12697	ZNF142 (directAnnotation).
ABI2	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
ABI2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ABI2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ABI2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ABI2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ABI2	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
ABI2	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
ABI2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ABI2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ABI2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ABI2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ABI2	transfac_pro__M05712	ZNF134 (directAnnotation).
ABI2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."