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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABHD5

Summary for ABHD5

Gene information	Gene symbol	ABHD5
	Ensembl ID	ENSG00000011198
	Entrez ID	51099
	Gene name	abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
	Synonyms	CGI-58\|NCIE2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ABHD5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.368885	8.59e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.294707	7.52e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.350278	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.552246	3.94e-15
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.305156	1.05e-24
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.318576	4.63e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.327559	2.29e-20

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Expression of ABHD5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABHD5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABHD5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABHD5	hsa-miR-4659a-3p	99.6008	NM_016006
ABHD5	hsa-miR-4659b-3p	99.6008	NM_016006
ABHD5	hsa-miR-30e-3p	99.3477	NM_016006
ABHD5	hsa-miR-30d-3p	99.3477	NM_016006
ABHD5	hsa-miR-30a-3p	99.3477	NM_016006
ABHD5	hsa-miR-4760-5p	97.2706	NM_016006
ABHD5	hsa-miR-8061	96.5374	NM_016006
ABHD5	hsa-miR-1297	95.7822	NM_016006
ABHD5	hsa-miR-3613-3p	95.6979	NM_016006
ABHD5	hsa-miR-4778-5p	95.0041	NM_016006
ABHD5	hsa-miR-607	94.6487	NM_016006
ABHD5	hsa-miR-4677-5p	93.9014	NM_016006
ABHD5	hsa-miR-26a-5p	93.553	NM_016006
ABHD5	hsa-miR-26b-5p	93.553	NM_016006
ABHD5	hsa-miR-140-5p	92.854	NM_016006
ABHD5	hsa-miR-4465	92.5032	NM_016006
ABHD5	hsa-miR-4637	92.3612	NM_016006
ABHD5	hsa-miR-6739-3p	92.3578	NM_016006
ABHD5	hsa-miR-19b-3p	92.0367	NM_016006
ABHD5	hsa-miR-19a-3p	92.0367	NM_016006
ABHD5	hsa-miR-1283	91.5459	NM_016006
ABHD5	hsa-miR-335-3p	90.9025	NM_016006
ABHD5	hsa-miR-7844-5p	89.9339	NM_016006
ABHD5	hsa-miR-224-5p	89.7189	NM_016006
ABHD5	hsa-miR-4460	89.148	NM_016006
ABHD5	hsa-miR-6508-5p	88.8695	NM_016006
ABHD5	hsa-miR-8067	87.854	NM_016006
ABHD5	hsa-miR-6871-3p	87.8328	NM_016006
ABHD5	hsa-miR-4725-3p	86.6528	NM_016006
ABHD5	hsa-miR-6780b-5p	86.6528	NM_016006
ABHD5	hsa-miR-106b-5p	86.382	NM_016006
ABHD5	hsa-miR-124-3p	86.382	NM_016006
ABHD5	hsa-miR-506-3p	86.382	NM_016006
ABHD5	hsa-miR-20a-5p	86.382	NM_016006
ABHD5	hsa-miR-548c-3p	85.1607	NM_016006
ABHD5	hsa-miR-17-5p	85.1488	NM_016006
ABHD5	hsa-miR-519d-3p	85.1488	NM_016006
ABHD5	hsa-miR-106a-5p	85.1488	NM_016006
ABHD5	hsa-miR-4482-3p	84.7907	NM_016006
ABHD5	hsa-miR-1303	84.654	NM_016006
ABHD5	hsa-miR-4271	84.2968	NM_016006
ABHD5	hsa-miR-889-3p	83.4887	NM_016006
ABHD5	hsa-miR-374a-5p	83.4751	NM_016006
ABHD5	hsa-miR-518a-5p	83.3565	NM_016006
ABHD5	hsa-miR-527	83.3565	NM_016006
ABHD5	hsa-miR-6883-3p	83.08	NM_016006
ABHD5	hsa-miR-299-5p	82.9055	NM_016006
ABHD5	hsa-miR-6868-5p	82.786	NM_016006
ABHD5	hsa-miR-3137	82.7758	NM_016006
ABHD5	hsa-miR-8084	82.2064	NM_016006

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Motifs and transcription factors (TFs) regulating ABHD5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABHD5	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
ABHD5	hdpi__FLI1	FLI1 (directAnnotation).
ABHD5	transfac_pro__M00492	STAT1 (directAnnotation).
ABHD5	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ABHD5	dbtfbs__ZNF423_HEK293_ENCSR477OJI_merged_N1	ZNF423 (directAnnotation).
ABHD5	metacluster_80.6	ZIC4 (directAnnotation).
ABHD5	kznf__ZNF445_Imbeault2017_OM_MEME	ZNF445 (directAnnotation).
ABHD5	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
ABHD5	transfac_pro__M06314	ZNF239 (directAnnotation).
ABHD5	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
ABHD5	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ABHD5	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ABHD5	transfac_pro__M06126	ZNF43 (directAnnotation).
ABHD5	transfac_public__M00240	NKX2-5 (directAnnotation).
ABHD5	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."