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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC3H13

Summary for ZC3H13

Gene information	Gene symbol	ZC3H13
	Ensembl ID	ENSG00000123200
	Entrez ID	23091
	Gene name	zinc finger CCCH-type containing 13
	Synonyms	DKFZp434D1812\|KIAA0853\|Xio
	Gene type	protein_coding
	UniProtAcc	Q5T200

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Dataset with differentially expressed gene: ZC3H13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.370324	5.57e-21
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.303069	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.402686	3.51e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.368069	1.49e-20

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Expression of ZC3H13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZC3H13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZC3H13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC3H13	hsa-miR-371b-5p	96.7532	NM_015070
ZC3H13	hsa-miR-373-5p	96.7532	NM_015070
ZC3H13	hsa-miR-616-5p	96.7532	NM_015070
ZC3H13	hsa-miR-580-5p	96.7285	NM_015070
ZC3H13	hsa-miR-15a-5p	90.7811	NM_015070
ZC3H13	hsa-miR-15b-5p	90.7811	NM_015070
ZC3H13	hsa-miR-195-5p	90.7811	NM_015070
ZC3H13	hsa-miR-16-5p	90.7811	NM_015070
ZC3H13	hsa-miR-302e	90.1339	NM_015070
ZC3H13	hsa-miR-424-5p	90.0426	NM_015070
ZC3H13	hsa-miR-6838-5p	90.0426	NM_015070
ZC3H13	hsa-miR-497-5p	90.0426	NM_015070
ZC3H13	hsa-miR-539-3p	89.9792	NM_015070
ZC3H13	hsa-miR-485-3p	89.9792	NM_015070
ZC3H13	hsa-miR-6756-3p	89.5391	NM_015070
ZC3H13	hsa-miR-3127-3p	89.5391	NM_015070
ZC3H13	hsa-miR-495-5p	89.5204	NM_015070
ZC3H13	hsa-miR-1208	88.9581	NM_015070
ZC3H13	hsa-miR-4524a-3p	88.6287	NM_015070
ZC3H13	hsa-miR-4524b-5p	88.0814	NM_015070
ZC3H13	hsa-miR-4524a-5p	88.0814	NM_015070
ZC3H13	hsa-miR-3606-5p	87.3853	NM_015070
ZC3H13	hsa-miR-302b-3p	87.2523	NM_015070
ZC3H13	hsa-miR-302c-3p	87.2523	NM_015070
ZC3H13	hsa-miR-302d-3p	87.2523	NM_015070
ZC3H13	hsa-miR-302a-3p	87.2523	NM_015070
ZC3H13	hsa-miR-520a-3p	85.2369	NM_015070
ZC3H13	hsa-miR-520c-3p	85.2369	NM_015070
ZC3H13	hsa-miR-372-3p	85.2369	NM_015070
ZC3H13	hsa-miR-520b-3p	85.2369	NM_015070
ZC3H13	hsa-miR-373-3p	85.2369	NM_015070
ZC3H13	hsa-miR-520e-3p	85.2369	NM_015070
ZC3H13	hsa-miR-520d-3p	85.2369	NM_015070
ZC3H13	hsa-miR-555	85.2173	NM_015070
ZC3H13	hsa-miR-2053	84.8359	NM_015070
ZC3H13	hsa-miR-1229-5p	83.3634	NM_015070
ZC3H13	hsa-miR-655-3p	83.0664	NM_015070
ZC3H13	hsa-miR-2467-5p	81.6779	NM_015070
ZC3H13	hsa-miR-548p	81.2099	NM_015070

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Motifs and transcription factors (TFs) regulating ZC3H13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC3H13	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZC3H13	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZC3H13	transfac_pro__M07397	ZNF148 (directAnnotation).
ZC3H13	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZC3H13	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ZC3H13	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ZC3H13	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZC3H13	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZC3H13	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ZC3H13	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ZC3H13	transfac_pro__M01175	ZBTB7B (directAnnotation).
ZC3H13	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZC3H13	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZC3H13	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZC3H13	transfac_pro__M01303	SP1 (directAnnotation).
ZC3H13	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZC3H13	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZC3H13	transfac_pro__M02090	E2F4 (directAnnotation).
ZC3H13	transfac_pro__M01714	KLF15 (directAnnotation).
ZC3H13	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZC3H13	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ZC3H13	transfac_pro__M02089	E2F3 (directAnnotation).
ZC3H13	metacluster_3.14	WT1; WT1 (directAnnotation).
ZC3H13	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZC3H13	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ZC3H13	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZC3H13	cisbp__M07938	E2F1 (directAnnotation).
ZC3H13	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZC3H13	transfac_pro__M07436	WT1 (directAnnotation).
ZC3H13	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZC3H13	transfac_pro__M02898	SMAD3 (directAnnotation).
ZC3H13	transfac_public__M00491	PATZ1 (directAnnotation).
ZC3H13	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ZC3H13	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZC3H13	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZC3H13	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
ZC3H13	transfac_pro__M00652	NRF1 (directAnnotation).
ZC3H13	transfac_pro__M01298	MECP2 (directAnnotation).
ZC3H13	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZC3H13	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ZC3H13	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ZC3H13	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ZC3H13	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
ZC3H13	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ZC3H13	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ZC3H13	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ZC3H13	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ZC3H13	transfac_pro__M04826	EP300 (directAnnotation).
ZC3H13	cisbp__M02645	ETS1 (directAnnotation).
ZC3H13	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."