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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UFM1

Summary for UFM1

Gene information	Gene symbol	UFM1
	Ensembl ID	ENSG00000120686
	Entrez ID	51569
	Gene name	ubiquitin fold modifier 1
	Synonyms	bA131P10.1\|C13orf20
	Gene type	protein_coding
	UniProtAcc	P61960

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Dataset with differentially expressed gene: UFM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.01286	6.93e-12
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.393908	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.3837	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.287285	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.516094	1.68e-44
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.437881	8.68e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.71143	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.412385	5.60e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.58617	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.250526	4.62e-29

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Expression of UFM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UFM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UFM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UFM1	hsa-miR-7-2-3p	97.1647	NM_001286706
UFM1	hsa-miR-7-1-3p	96.7407	NM_001286706
UFM1	hsa-miR-934	96.1554	NM_001286706
UFM1	hsa-miR-3529-3p	95.9144	NM_001286704
UFM1	hsa-miR-4760-3p	95.7176	NM_001286706
UFM1	hsa-miR-4282	95.4642	NM_001286706
UFM1	hsa-miR-5187-3p	95.1003	NM_001286704
UFM1	hsa-miR-548c-3p	94.8722	NM_001286706
UFM1	hsa-miR-3065-5p	94.6624	NM_001286704
UFM1	hsa-miR-5688	93.406	NM_001286706
UFM1	hsa-miR-495-3p	92.9856	NM_001286706
UFM1	hsa-miR-548n	92.7372	NM_001286704
UFM1	hsa-miR-3613-3p	92.0281	NM_001286704
UFM1	hsa-miR-1245b-3p	91.032	NM_001286704
UFM1	hsa-miR-1260b	90.4854	NM_001286704
UFM1	hsa-miR-1260a	90.4854	NM_001286704
UFM1	hsa-miR-4475	89.6015	NM_001286704
UFM1	hsa-miR-590-3p	89.2418	NM_001286704
UFM1	hsa-miR-548an	88.3435	NM_001286706
UFM1	hsa-miR-6728-3p	87.8747	NM_001286704
UFM1	hsa-miR-548x-3p	87.8234	NM_001286704
UFM1	hsa-miR-548aj-3p	87.8234	NM_001286704
UFM1	hsa-miR-4775	86.5954	NM_001286704
UFM1	hsa-miR-3936	86.5197	NM_001286704
UFM1	hsa-miR-190a-3p	85.9998	NM_001286706
UFM1	hsa-miR-3182	85.9148	NM_001286706
UFM1	hsa-miR-4320	85.6419	NM_001286704
UFM1	hsa-miR-545-5p	85.5024	NM_001286706
UFM1	hsa-miR-6739-3p	85.4817	NM_001286704
UFM1	hsa-miR-3059-3p	84.5683	NM_001286706
UFM1	hsa-miR-410-3p	84.426	NM_001286704
UFM1	hsa-miR-4420	84.1269	NM_001286704
UFM1	hsa-miR-4789-5p	83.6897	NM_001286704
UFM1	hsa-miR-548aq-3p	82.6376	NM_001286704
UFM1	hsa-miR-548ah-3p	82.6376	NM_001286704
UFM1	hsa-miR-548ae-3p	82.6376	NM_001286704
UFM1	hsa-miR-548am-3p	82.6376	NM_001286704
UFM1	hsa-miR-548j-3p	82.6376	NM_001286704
UFM1	hsa-miR-181b-2-3p	82.5158	NM_001286704
UFM1	hsa-miR-181b-3p	82.5158	NM_001286704
UFM1	hsa-miR-642a-5p	82.1799	NM_001286704
UFM1	hsa-miR-299-5p	82.1362	NM_001286704
UFM1	hsa-miR-4512	81.5172	NM_001286704
UFM1	hsa-miR-4495	80.9663	NM_001286706
UFM1	hsa-miR-1297	80.9267	NM_001286706
UFM1	hsa-miR-6853-3p	80.8494	NM_001286704

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Motifs and transcription factors (TFs) regulating UFM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UFM1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
UFM1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
UFM1	hdpi__HIP2	UBE2K (directAnnotation).
UFM1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
UFM1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UFM1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UFM1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
UFM1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
UFM1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UFM1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UFM1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UFM1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UFM1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UFM1	metacluster_151.2	ZNF23 (directAnnotation).
UFM1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UFM1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
UFM1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
UFM1	transfac_pro__M00938	E2F1 (directAnnotation).
UFM1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
UFM1	transfac_pro__M01973	PLAG1 (directAnnotation).
UFM1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
UFM1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
UFM1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
UFM1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UFM1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
UFM1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
UFM1	hdpi__TIMELESS	TIMELESS (directAnnotation).
UFM1	metacluster_191.5	SPDEF (inferredBy_Orthology).
UFM1	hdpi__TP73	TP73 (directAnnotation).
UFM1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
UFM1	hdpi__ELF2	ELF2 (directAnnotation).
UFM1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
UFM1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
UFM1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
UFM1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
UFM1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
UFM1	transfac_pro__M04826	EP300 (directAnnotation).
UFM1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
UFM1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
UFM1	hdpi__ETV4	ETV4 (directAnnotation).
UFM1	hdpi__FLI1	FLI1 (directAnnotation).
UFM1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
UFM1	cisbp__M02645	ETS1 (directAnnotation).
UFM1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
UFM1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
UFM1	jaspar__MA1708.1	ETV7 (directAnnotation).
UFM1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
UFM1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
UFM1	metacluster_183.4	ETS1 (inferredBy_Orthology).
UFM1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."