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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBXN7

Summary for UBXN7

Gene information	Gene symbol	UBXN7
	Ensembl ID	ENSG00000163960
	Entrez ID	26043
	Gene name	UBX domain protein 7
	Synonyms	KIAA0794\|UBXD7
	Gene type	protein_coding
	UniProtAcc	O94888

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Dataset with differentially expressed gene: UBXN7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.387035	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.254768	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.336492	3.38e-26
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.455782	0.00e+00

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Expression of UBXN7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBXN7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBXN7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBXN7	hsa-miR-4297	93.5314	NM_015562
UBXN7	hsa-miR-4704-3p	93.1652	NM_015562
UBXN7	hsa-miR-4784	93.0771	NM_015562
UBXN7	hsa-miR-3150b-3p	93.0771	NM_015562
UBXN7	hsa-miR-122-5p	92.6221	NM_015562
UBXN7	hsa-miR-10522-5p	92.3495	NM_015562
UBXN7	hsa-miR-5587-5p	92.2499	NM_015562
UBXN7	hsa-miR-4727-5p	88.2438	NM_015562
UBXN7	hsa-miR-4668-5p	87.7262	NM_015562
UBXN7	hsa-miR-29b-2-5p	86.3345	NM_015562
UBXN7	hsa-miR-3185	86.0253	NM_015562
UBXN7	hsa-miR-5581-5p	85.7831	NM_015562
UBXN7	hsa-miR-4672	85.7484	NM_015562
UBXN7	hsa-miR-499b-5p	85.3596	NM_015562
UBXN7	hsa-miR-2467-3p	84.4209	NM_015562
UBXN7	hsa-miR-3692-3p	84.0387	NM_015562
UBXN7	hsa-miR-6747-3p	83.8631	NM_015562
UBXN7	hsa-miR-12135	83.5921	NM_015562
UBXN7	hsa-miR-5584-5p	83.0287	NM_015562
UBXN7	hsa-miR-8057	82.9798	NM_015562
UBXN7	hsa-miR-98-3p	82.5006	NM_015562
UBXN7	hsa-miR-6858-5p	82.0611	NM_015562
UBXN7	hsa-miR-302c-5p	81.9201	NM_015562
UBXN7	hsa-miR-4436a	81.8866	NM_015562
UBXN7	hsa-miR-5000-3p	81.8866	NM_015562
UBXN7	hsa-miR-10526-3p	80.4975	NM_015562
UBXN7	hsa-let-7b-3p	80.2577	NM_015562
UBXN7	hsa-let-7a-3p	80.2577	NM_015562
UBXN7	hsa-let-7f-1-3p	80.2577	NM_015562

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Motifs and transcription factors (TFs) regulating UBXN7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBXN7	metacluster_135.11	NR2C2 (directAnnotation).
UBXN7	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBXN7	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBXN7	metacluster_7.13	ZFX (directAnnotation).
UBXN7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
UBXN7	cisbp__M00968	MTF2 (directAnnotation).
UBXN7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBXN7	metacluster_160.20	JUND; PRDM15 (directAnnotation).
UBXN7	cisbp__M00341	PAX6 (directAnnotation).
UBXN7	metacluster_198.3	ZFP64 (directAnnotation).
UBXN7	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UBXN7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBXN7	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBXN7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBXN7	cisbp__M00788	ZFY (inferredBy_Orthology).
UBXN7	metacluster_175.1	ZNF283 (directAnnotation).
UBXN7	hdpi__ZNF304	ZNF304 (directAnnotation).
UBXN7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBXN7	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UBXN7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBXN7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBXN7	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBXN7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBXN7	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBXN7	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBXN7	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
UBXN7	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBXN7	jaspar__MA1721.1	ZNF93 (directAnnotation).
UBXN7	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
UBXN7	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
UBXN7	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
UBXN7	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
UBXN7	jaspar__MA0748.2	YY2 (directAnnotation).
UBXN7	swissregulon__hs__CHD1	CHD1 (directAnnotation).
UBXN7	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
UBXN7	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
UBXN7	cisbp__M01863	ZNF711 (inferredBy_Orthology).
UBXN7	transfac_pro__M07310	SP5 (directAnnotation).
UBXN7	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
UBXN7	transfac_pro__M00938	E2F1 (directAnnotation).
UBXN7	transfac_pro__M04893	TAF1 (directAnnotation).
UBXN7	transfac_pro__M12697	ZNF142 (directAnnotation).
UBXN7	tfdimers__MD00364	WT1 (directAnnotation).
UBXN7	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
UBXN7	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
UBXN7	transfac_pro__M01973	PLAG1 (directAnnotation).
UBXN7	tfdimers__MD00483	ZBTB14 (directAnnotation).
UBXN7	transfac_pro__M01303	SP1 (directAnnotation).
UBXN7	metacluster_143.13	ZBTB7A (directAnnotation).
UBXN7	transfac_pro__M07387	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."