Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBQLN1

Summary for UBQLN1

Gene information	Gene symbol	UBQLN1
	Ensembl ID	ENSG00000135018
	Entrez ID	29979
	Gene name	ubiquilin 1
	Synonyms	DA41\|DSK2\|PLIC-1\|XDRP1
	Gene type	protein_coding
	UniProtAcc	Q9UMX0

Top

Dataset with differentially expressed gene: UBQLN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.34352	2.77e-14
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.357909	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.254701	1.31e-41
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.290478	2.19e-40
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.969331	0.00e+00

Top

Expression of UBQLN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to UBQLN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating UBQLN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBQLN1	hsa-miR-548e-5p	96.0902	NM_013438
UBQLN1	hsa-miR-4649-3p	95.9615	NM_053067
UBQLN1	hsa-miR-6835-3p	93.8201	NM_053067
UBQLN1	hsa-miR-9902	92.9838	NM_013438
UBQLN1	hsa-miR-600	92.527	NM_013438
UBQLN1	hsa-miR-155-5p	92.0155	NM_053067
UBQLN1	hsa-miR-1286	91.8689	NM_053067
UBQLN1	hsa-miR-3646	91.576	NM_013438
UBQLN1	hsa-miR-1284	91.5611	NM_053067
UBQLN1	hsa-miR-12136	91.4218	NM_013438
UBQLN1	hsa-miR-8074	89.7207	NM_053067
UBQLN1	hsa-miR-3143	87.7843	NM_013438
UBQLN1	hsa-miR-4275	87.5437	NM_013438
UBQLN1	hsa-miR-302c-5p	87.1677	NM_013438
UBQLN1	hsa-miR-548aw	87.0651	NM_013438
UBQLN1	hsa-miR-3156-3p	85.7153	NM_013438
UBQLN1	hsa-miR-623	85.6277	NM_053067
UBQLN1	hsa-miR-4307	84.8668	NM_053067
UBQLN1	hsa-miR-4422	84.6854	NM_053067
UBQLN1	hsa-miR-199b-3p	84.1366	NM_053067
UBQLN1	hsa-miR-3129-5p	84.1366	NM_053067
UBQLN1	hsa-miR-199a-3p	84.1366	NM_053067
UBQLN1	hsa-miR-33a-3p	83.6137	NM_053067
UBQLN1	hsa-let-7f-1-3p	83.5964	NM_013438
UBQLN1	hsa-let-7a-3p	83.5964	NM_013438
UBQLN1	hsa-miR-98-3p	83.5964	NM_013438
UBQLN1	hsa-let-7b-3p	83.5964	NM_013438
UBQLN1	hsa-miR-4698	83.5548	NM_053067
UBQLN1	hsa-miR-6802-3p	83.5536	NM_053067
UBQLN1	hsa-miR-6741-3p	83.2318	NM_013438
UBQLN1	hsa-miR-887-5p	82.7471	NM_053067
UBQLN1	hsa-miR-6852-5p	82.5486	NM_053067
UBQLN1	hsa-miR-8053	81.7016	NM_053067
UBQLN1	hsa-miR-3180-5p	81.6985	NM_053067
UBQLN1	hsa-miR-1305	80.8118	NM_053067
UBQLN1	hsa-miR-512-5p	80.6725	NM_053067
UBQLN1	hsa-miR-520e-5p	80.5492	NM_053067
UBQLN1	hsa-miR-1257	80.4728	NM_053067
UBQLN1	hsa-miR-3117-5p	80.4142	NM_013438
UBQLN1	hsa-miR-3123	80.199	NM_013438

Page: 1

Top

Motifs and transcription factors (TFs) regulating UBQLN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBQLN1	metacluster_7.13	ZFX (directAnnotation).
UBQLN1	metacluster_151.2	ZNF23 (directAnnotation).
UBQLN1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UBQLN1	transfac_pro__M05479	ZNF580 (directAnnotation).
UBQLN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBQLN1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
UBQLN1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBQLN1	jaspar__MA0748.2	YY2 (directAnnotation).
UBQLN1	transfac_pro__M05628	ZNF735 (directAnnotation).
UBQLN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBQLN1	jaspar__MA0079.5	SP1 (directAnnotation).
UBQLN1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
UBQLN1	transfac_pro__M04826	EP300 (directAnnotation).
UBQLN1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
UBQLN1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
UBQLN1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
UBQLN1	transfac_pro__M01783	SP2 (directAnnotation).
UBQLN1	cisbp__M00341	PAX6 (directAnnotation).
UBQLN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
UBQLN1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
UBQLN1	transfac_pro__M01253	CNOT3 (directAnnotation).
UBQLN1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
UBQLN1	cisbp__M00968	MTF2 (directAnnotation).
UBQLN1	transfac_pro__M04817	ZBTB33 (directAnnotation).
UBQLN1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
UBQLN1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
UBQLN1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
UBQLN1	tfdimers__MD00038	TFAP2C (directAnnotation).
UBQLN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UBQLN1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBQLN1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBQLN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBQLN1	cisbp__M00788	ZFY (inferredBy_Orthology).
UBQLN1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UBQLN1	metacluster_175.1	ZNF283 (directAnnotation).
UBQLN1	hdpi__ZNF304	ZNF304 (directAnnotation).
UBQLN1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBQLN1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UBQLN1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBQLN1	transfac_pro__M01199	TRIM28 (directAnnotation).
UBQLN1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBQLN1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBQLN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBQLN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBQLN1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBQLN1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
UBQLN1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBQLN1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
UBQLN1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
UBQLN1	jaspar__MA1721.1	ZNF93 (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."