Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRA2A

Summary for TRA2A

Gene information	Gene symbol	TRA2A
	Ensembl ID	ENSG00000164548
	Entrez ID	29896
	Gene name	transformer 2 alpha homolog
	Synonyms	AWMS1\|htra-2-alpha
	Gene type	protein_coding
	UniProtAcc	Q13595

Top

Dataset with differentially expressed gene: TRA2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.263414	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.303809	3.26e-09
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.274651	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.265908	5.89e-06
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.596044	1.15e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.802534	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.358846	3.31e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.336271	7.70e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.68277	1.24e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.459435	5.45e-21

Top

Expression of TRA2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TRA2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TRA2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRA2A	hsa-miR-10527-5p	97.9519	NM_001282757
TRA2A	hsa-miR-607	97.7207	NM_001282757
TRA2A	hsa-miR-3658	95.6168	NM_001282757
TRA2A	hsa-miR-3529-3p	95.1097	NM_001282757
TRA2A	hsa-miR-520f-5p	95.0756	NM_001282757
TRA2A	hsa-miR-208b-5p	93.8486	NM_001282759
TRA2A	hsa-miR-208a-5p	93.8486	NM_001282759
TRA2A	hsa-miR-548e-5p	93.8299	NM_001282757
TRA2A	hsa-miR-216b-3p	93.7753	NM_001282757
TRA2A	hsa-miR-6892-5p	93.2448	NM_001282759
TRA2A	hsa-miR-4275	92.8498	NM_001282757
TRA2A	hsa-miR-583	92.5035	NM_001282759
TRA2A	hsa-miR-3916	91.7708	NM_001282759
TRA2A	hsa-miR-196a-1-3p	91.0757	NM_001282759
TRA2A	hsa-miR-3671	89.8684	NM_001282757
TRA2A	hsa-miR-3124-3p	89.8622	NM_001282759
TRA2A	hsa-miR-3125	89.0508	NM_001282759
TRA2A	hsa-miR-6859-5p	89.0508	NM_001282759
TRA2A	hsa-miR-548at-5p	87.9594	NM_001282759
TRA2A	hsa-miR-888-3p	86.8377	NM_001282759
TRA2A	hsa-miR-330-3p	86.6229	NM_001282757
TRA2A	hsa-miR-4803	85.542	NM_001282759
TRA2A	hsa-miR-548p	85.1694	NM_001282759
TRA2A	hsa-miR-95-5p	85.1611	NM_001282759
TRA2A	hsa-miR-4420	84.9701	NM_001282759
TRA2A	hsa-miR-181b-3p	84.9701	NM_001282759
TRA2A	hsa-miR-181b-2-3p	84.9701	NM_001282759
TRA2A	hsa-let-7b-3p	83.0453	NM_001282757
TRA2A	hsa-let-7a-3p	83.0453	NM_001282757
TRA2A	hsa-let-7f-1-3p	83.0453	NM_001282757
TRA2A	hsa-miR-98-3p	83.0453	NM_001282757
TRA2A	hsa-miR-6745	81.7522	NM_001282759
TRA2A	hsa-miR-520d-5p	80.7489	NM_001282757
TRA2A	hsa-miR-524-5p	80.7489	NM_001282757
TRA2A	hsa-miR-3920	80.5001	NM_001282757

Page: 1

Top

Motifs and transcription factors (TFs) regulating TRA2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRA2A	transfac_pro__M05481	ZNF202 (directAnnotation).
TRA2A	transfac_pro__M05846	ZNF689 (directAnnotation).
TRA2A	transfac_pro__M06564	ZNF578 (directAnnotation).
TRA2A	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
TRA2A	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
TRA2A	metacluster_172.6	CHD2; E2F1 (directAnnotation).
TRA2A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
TRA2A	metacluster_3.10	KLF2; KLF4 (directAnnotation).
TRA2A	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
TRA2A	metacluster_141.2	E2F2; E2F3 (directAnnotation).
TRA2A	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
TRA2A	transfac_pro__M01783	SP2 (directAnnotation).
TRA2A	cisbp__M00341	PAX6 (directAnnotation).
TRA2A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TRA2A	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
TRA2A	transfac_pro__M01253	CNOT3 (directAnnotation).
TRA2A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TRA2A	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
TRA2A	cisbp__M00968	MTF2 (directAnnotation).
TRA2A	transfac_pro__M04817	ZBTB33 (directAnnotation).
TRA2A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TRA2A	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TRA2A	jaspar__MA0748.2	YY2 (directAnnotation).
TRA2A	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
TRA2A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TRA2A	transfac_pro__M04918	EGR1 (directAnnotation).
TRA2A	hdpi__HIP2	UBE2K (directAnnotation).
TRA2A	transfac_pro__M02913	SP140 (inferredBy_Orthology).
TRA2A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TRA2A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TRA2A	transfac_pro__M02898	SMAD3 (directAnnotation).
TRA2A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TRA2A	metacluster_191.5	SPDEF (inferredBy_Orthology).
TRA2A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TRA2A	hdpi__TIMELESS	TIMELESS (directAnnotation).
TRA2A	transfac_pro__M04893	TAF1 (directAnnotation).
TRA2A	cisbp__M00249	WT1 (directAnnotation).
TRA2A	transfac_pro__M00430	E2F1 (directAnnotation).
TRA2A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TRA2A	hdpi__ZNF304	ZNF304 (directAnnotation).
TRA2A	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
TRA2A	transfac_pro__M00938	E2F1 (directAnnotation).
TRA2A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TRA2A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TRA2A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TRA2A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TRA2A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRA2A	jaspar__MA1721.1	ZNF93 (directAnnotation).
TRA2A	metacluster_151.2	ZNF23 (directAnnotation).
TRA2A	transfac_pro__M01199	TRIM28 (directAnnotation).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."