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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM123

Summary for TMEM123

Gene information	Gene symbol	TMEM123
	Ensembl ID	ENSG00000152558
	Entrez ID	114908
	Gene name	transmembrane protein 123
	Synonyms	KCT3\|PORIMIN
	Gene type	protein_coding
	UniProtAcc	Q8N131

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Dataset with differentially expressed gene: TMEM123

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.930181	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.907913	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.417398	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.294178	4.60e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.266345	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.292648	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.308139	1.92e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.369309	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.290833	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.733136	2.45e-42
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.250937	1.10e-17
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.436695	6.18e-15
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.332621	1.98e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.783148	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.348324	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.267526	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.370958	2.39e-12
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.287545	1.26e-02
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.481319	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.633916	0.00e+00

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Expression of TMEM123 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM123

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM123

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM123	hsa-miR-6830-5p	94.8839	NM_052932
TMEM123	hsa-miR-644a	94.734	NM_052932
TMEM123	hsa-miR-8068	94.7085	NM_052932
TMEM123	hsa-miR-561-5p	93.9799	NM_052932
TMEM123	hsa-miR-5582-3p	93.1314	NM_052932
TMEM123	hsa-miR-4720-3p	92.4195	NM_052932
TMEM123	hsa-miR-5680	90.9529	NM_052932
TMEM123	hsa-miR-518a-5p	90.0966	NM_052932
TMEM123	hsa-miR-527	90.0966	NM_052932
TMEM123	hsa-miR-374a-5p	89.7201	NM_052932
TMEM123	hsa-miR-6835-3p	89.0141	NM_052932
TMEM123	hsa-miR-374b-5p	88.4739	NM_052932
TMEM123	hsa-miR-520e-3p	87.6731	NM_052932
TMEM123	hsa-miR-373-3p	87.6731	NM_052932
TMEM123	hsa-miR-302e	87.6731	NM_052932
TMEM123	hsa-miR-302b-3p	87.6731	NM_052932
TMEM123	hsa-miR-520a-3p	87.6731	NM_052932
TMEM123	hsa-miR-520b-3p	87.6731	NM_052932
TMEM123	hsa-miR-302c-3p	87.6731	NM_052932
TMEM123	hsa-miR-302a-3p	87.6731	NM_052932
TMEM123	hsa-miR-520d-3p	87.6731	NM_052932
TMEM123	hsa-miR-372-3p	87.6731	NM_052932
TMEM123	hsa-miR-302d-3p	87.6731	NM_052932
TMEM123	hsa-miR-520c-3p	87.6731	NM_052932
TMEM123	hsa-miR-196a-1-3p	87.4145	NM_052932
TMEM123	hsa-miR-4528	86.6901	NM_052932
TMEM123	hsa-miR-4777-5p	86.6114	NM_052932
TMEM123	hsa-miR-6735-3p	86.0797	NM_052932
TMEM123	hsa-miR-450b-5p	85.5695	NM_052932
TMEM123	hsa-miR-514b-5p	85.399	NM_052932
TMEM123	hsa-miR-513c-5p	85.399	NM_052932
TMEM123	hsa-miR-802	83.7251	NM_052932
TMEM123	hsa-miR-4446-5p	82.7182	NM_052932
TMEM123	hsa-miR-4742-3p	82.4878	NM_052932
TMEM123	hsa-miR-6830-3p	81.5603	NM_052932
TMEM123	hsa-miR-4725-5p	80.7146	NM_052932
TMEM123	hsa-miR-504-5p	80.7146	NM_052932
TMEM123	hsa-miR-4670-3p	80.583	NM_052932
TMEM123	hsa-miR-4262	80.4685	NM_052932

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Motifs and transcription factors (TFs) regulating TMEM123

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM123	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
TMEM123	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TMEM123	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TMEM123	transfac_pro__M06071	ZNF814 (directAnnotation).
TMEM123	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TMEM123	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TMEM123	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TMEM123	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TMEM123	transfac_pro__M00652	NRF1 (directAnnotation).
TMEM123	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TMEM123	transfac_pro__M04866	HDAC2 (directAnnotation).
TMEM123	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TMEM123	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
TMEM123	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
TMEM123	jaspar__MA1125.1	ZNF384 (directAnnotation).
TMEM123	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
TMEM123	transfac_pro__M05421	MYNN (inferredBy_Orthology).
TMEM123	jaspar__MA1483.2	ELF2 (directAnnotation).
TMEM123	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TMEM123	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TMEM123	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
TMEM123	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
TMEM123	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
TMEM123	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
TMEM123	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TMEM123	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TMEM123	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TMEM123	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TMEM123	hdpi__TP73	TP73 (directAnnotation).
TMEM123	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
TMEM123	transfac_pro__M04862	NRF1 (directAnnotation).
TMEM123	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
TMEM123	jaspar__MA0748.2	YY2 (directAnnotation).
TMEM123	transfac_pro__M00492	STAT1 (directAnnotation).
TMEM123	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
TMEM123	transfac_pro__M06188	ZNF135 (directAnnotation).
TMEM123	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
TMEM123	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
TMEM123	tfdimers__MD00593	GABPA; PITX3 (directAnnotation).
TMEM123	metacluster_139.9	TFE3 (inferredBy_Orthology).
TMEM123	metacluster_168.16	FOXG1 (inferredBy_Orthology).
TMEM123	taipale_cyt_meth__NR4A1_NAAAGGTCAN_eDBD_1	NR4A1 (directAnnotation).
TMEM123	transfac_pro__M06519	ZNF397 (directAnnotation).
TMEM123	taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAP	ETV4; FOXO1 (directAnnotation).
TMEM123	metacluster_79.37	FOXJ3 (inferredBy_Orthology).
TMEM123	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TMEM123	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
TMEM123	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
TMEM123	cisbp__M07938	E2F1 (directAnnotation).
TMEM123	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."