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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TACC1

Summary for TACC1

Gene information	Gene symbol	TACC1
	Ensembl ID	ENSG00000147526
	Entrez ID	6867
	Gene name	transforming acidic coiled-coil containing protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TACC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.382461	1.66e-20
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.358209	7.15e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.618343	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.292942	7.51e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.43782	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.31557	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.870505	0.00e+00

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Expression of TACC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TACC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TACC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TACC1	hsa-miR-6867-5p	98.9868	NM_006283
TACC1	hsa-miR-3148	98.7503	NM_006283
TACC1	hsa-miR-374a-5p	98.5475	NM_006283
TACC1	hsa-miR-374b-5p	97.9028	NM_006283
TACC1	hsa-miR-3163	96.9812	NM_006283
TACC1	hsa-miR-3613-3p	95.8506	NM_006283
TACC1	hsa-miR-3688-3p	95.337	NM_006283
TACC1	hsa-miR-1468-3p	92.1875	NM_006283
TACC1	hsa-miR-6809-3p	91.7741	NM_006283
TACC1	hsa-miR-506-5p	90.8832	NM_006283
TACC1	hsa-miR-6124	90.691	NM_006283
TACC1	hsa-miR-4802-3p	90.4361	NM_006283
TACC1	hsa-miR-3156-5p	89.6861	NM_006283
TACC1	hsa-miR-766-3p	89.6407	NM_006283
TACC1	hsa-miR-1236-3p	89.4589	NM_006283
TACC1	hsa-miR-1277-5p	88.3767	NM_006283
TACC1	hsa-miR-607	87.8187	NM_006283
TACC1	hsa-miR-6888-3p	87.6768	NM_006283
TACC1	hsa-miR-494-3p	87.147	NM_006283
TACC1	hsa-miR-1-5p	86.9734	NM_006283
TACC1	hsa-miR-448	86.5078	NM_006283
TACC1	hsa-miR-5681a	85.7328	NM_006283
TACC1	hsa-miR-4742-5p	85.7111	NM_006283
TACC1	hsa-miR-6733-5p	85.4513	NM_006283
TACC1	hsa-miR-6739-5p	85.4513	NM_006283
TACC1	hsa-miR-4328	84.6898	NM_006283
TACC1	hsa-miR-4443	84.489	NM_006283
TACC1	hsa-miR-3925-3p	84.3376	NM_006283
TACC1	hsa-miR-4430	84.0947	NM_006283
TACC1	hsa-miR-3652	84.0947	NM_006283
TACC1	hsa-miR-4528	83.8111	NM_006283
TACC1	hsa-miR-4470	82.8858	NM_006283
TACC1	hsa-miR-182-5p	82.72	NM_006283
TACC1	hsa-miR-4677-5p	82.7036	NM_006283
TACC1	hsa-miR-483-3p	82.5852	NM_006283
TACC1	hsa-miR-4277	82.38	NM_006283
TACC1	hsa-miR-4474-5p	82.2282	NM_006283
TACC1	hsa-miR-3153	81.9146	NM_006283
TACC1	hsa-miR-31-5p	81.5904	NM_006283
TACC1	hsa-miR-4282	81.3138	NM_006283
TACC1	hsa-miR-6754-3p	80.9548	NM_006283
TACC1	hsa-miR-1912-5p	80.4521	NM_006283
TACC1	hsa-miR-412-3p	80.2048	NM_006283

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Motifs and transcription factors (TFs) regulating TACC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TACC1	metacluster_7.13	ZFX (directAnnotation).
TACC1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TACC1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TACC1	transfac_pro__M06071	ZNF814 (directAnnotation).
TACC1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TACC1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TACC1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
TACC1	cisbp__M00341	PAX6 (directAnnotation).
TACC1	transfac_pro__M01253	CNOT3 (directAnnotation).
TACC1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
TACC1	cisbp__M00968	MTF2 (directAnnotation).
TACC1	transfac_pro__M04817	ZBTB33 (directAnnotation).
TACC1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TACC1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TACC1	metacluster_135.11	NR2C2 (directAnnotation).
TACC1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TACC1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TACC1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TACC1	cisbp__M00788	ZFY (inferredBy_Orthology).
TACC1	transfac_pro__M01199	TRIM28 (directAnnotation).
TACC1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TACC1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TACC1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TACC1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TACC1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
TACC1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TACC1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
TACC1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
TACC1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TACC1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
TACC1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TACC1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
TACC1	transfac_pro__M00938	E2F1 (directAnnotation).
TACC1	transfac_pro__M04893	TAF1 (directAnnotation).
TACC1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
TACC1	transfac_pro__M12697	ZNF142 (directAnnotation).
TACC1	tfdimers__MD00364	WT1 (directAnnotation).
TACC1	transfac_pro__M04916	TAF1 (directAnnotation).
TACC1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TACC1	tfdimers__MD00483	ZBTB14 (directAnnotation).
TACC1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TACC1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
TACC1	transfac_pro__M00514	ATF4 (directAnnotation).
TACC1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TACC1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
TACC1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
TACC1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TACC1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
TACC1	metacluster_182.10	ZFX (directAnnotation).
TACC1	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."