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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STXBP6

Summary for STXBP6

Gene information	Gene symbol	STXBP6
	Ensembl ID	ENSG00000168952
	Entrez ID	29091
	Gene name	syntaxin binding protein 6
	Synonyms	amisyn\|HSPC156
	Gene type	protein_coding
	UniProtAcc	Q8NFX7

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Dataset with differentially expressed gene: STXBP6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-2.05318	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Progenitors	-0.370657	1.79e-02

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Expression of STXBP6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STXBP6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STXBP6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STXBP6	hsa-miR-6867-5p	99.6659	NM_014178
STXBP6	hsa-miR-146a-3p	98.3387	NM_001304476
STXBP6	hsa-miR-451b	97.1774	NM_014178
STXBP6	hsa-miR-590-3p	97.1354	NM_014178
STXBP6	hsa-miR-3148	96.5626	NM_001304476
STXBP6	hsa-miR-494-3p	94.5846	NM_001304476
STXBP6	hsa-miR-3978	94.0316	NM_001304476
STXBP6	hsa-miR-3919	93.4585	NM_014178
STXBP6	hsa-miR-10522-5p	91.005	NM_014178
STXBP6	hsa-miR-5584-5p	89.506	NM_001304476
STXBP6	hsa-miR-1284	88.8033	NM_014178
STXBP6	hsa-miR-133a-3p	88.6082	NM_001304476
STXBP6	hsa-miR-133b	88.6082	NM_001304476
STXBP6	hsa-miR-5692a	88.1925	NM_001304476
STXBP6	hsa-miR-4733-3p	88.1331	NM_014178
STXBP6	hsa-miR-548g-5p	87.2429	NM_001304476
STXBP6	hsa-miR-548f-5p	87.2429	NM_001304476
STXBP6	hsa-miR-548aj-5p	87.2429	NM_001304476
STXBP6	hsa-miR-548x-5p	87.2429	NM_001304476
STXBP6	hsa-miR-6809-3p	86.8993	NM_014178
STXBP6	hsa-miR-449b-3p	86.231	NM_014178
STXBP6	hsa-miR-3692-3p	84.0641	NM_014178
STXBP6	hsa-miR-545-3p	83.8778	NM_014178
STXBP6	hsa-miR-889-3p	83.7712	NM_014178
STXBP6	hsa-miR-1283	83.6909	NM_014178
STXBP6	hsa-miR-6814-5p	82.9668	NM_014178
STXBP6	hsa-miR-548p	82.7497	NM_001304476
STXBP6	hsa-miR-4680-3p	81.4548	NM_014178
STXBP6	hsa-miR-4424	81.3843	NM_014178
STXBP6	hsa-miR-5007-3p	81.3561	NM_014178
STXBP6	hsa-miR-1468-3p	80.8853	NM_001304476
STXBP6	hsa-miR-5191	80.8401	NM_014178
STXBP6	hsa-miR-8069	80.5655	NM_001304476
STXBP6	hsa-miR-6799-5p	80.5022	NM_014178

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Motifs and transcription factors (TFs) regulating STXBP6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STXBP6	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
STXBP6	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
STXBP6	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
STXBP6	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
STXBP6	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
STXBP6	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
STXBP6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
STXBP6	transfac_pro__M00652	NRF1 (directAnnotation).
STXBP6	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
STXBP6	transfac_pro__M04866	HDAC2 (directAnnotation).
STXBP6	jaspar__MA1122.1	TFDP1 (directAnnotation).
STXBP6	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
STXBP6	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
STXBP6	transfac_pro__M06113	ZNF12 (directAnnotation).
STXBP6	transfac_pro__M06578	ZNF594 (directAnnotation).
STXBP6	metacluster_172.19	HMGA2 (directAnnotation).
STXBP6	jaspar__MA0246.1	SIX1 (inferredBy_Orthology).
STXBP6	kznf__ZNF540_Imbeault2017_OM_MEME	ZNF540 (directAnnotation).
STXBP6	metacluster_7.12	ZNF506 (directAnnotation).
STXBP6	transfac_pro__M07390	NFE2L1 (directAnnotation).
STXBP6	metacluster_44.8	NKX3-2 (directAnnotation).
STXBP6	transfac_pro__M06014	ZFP69B (directAnnotation).
STXBP6	metacluster_169.2	GATA1; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; GATA2; GATA2; GATA2; GATA2; GATA2; GATA2; GATA2; GATA3; GATA3; GATA3; GATA3; GATA4; GATA4; GATA4; GATA4; GATA5; GATA5; GATA5; GATA5; GATA5; GATA6; GATA6; GATA6; SMARCC2; TRPS1 (directAnnotation). ANHX; GATA1; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; GATA2; GATA3; GATA3; GATA3; GATA3; GATA4; GATA4; GATA4; GATA5; GATA6; GATA6; GATA6; GATA6; SIX2; SIX3; SIX4; SIX5; SIX6; TRPS1; TRPS1; ZGLP1; ZGLP1 (inferredBy_Orthology).
STXBP6	transfac_pro__M06344	ZNF530 (directAnnotation).
STXBP6	kznf__ZNF35_Najafabadi2015_ChIP-seq	ZNF35 (directAnnotation).
STXBP6	transfac_pro__M05822	ZNF546 (directAnnotation).
STXBP6	transfac_pro__M02082	ISL2 (directAnnotation).
STXBP6	metacluster_9.25	UNCX (directAnnotation).
STXBP6	transfac_pro__M06197	ZNF84 (directAnnotation).
STXBP6	metacluster_9.23	HOXA4 (directAnnotation).
STXBP6	metacluster_9.48	POU3F1 (directAnnotation).
STXBP6	transfac_pro__M06182	ZNF132 (directAnnotation).
STXBP6	metacluster_9.30	POU3F2 (directAnnotation).
STXBP6	transfac_pro__M06640	ZNF251 (directAnnotation).
STXBP6	nitta__so_TATCGC20NGCG_KG_RTATCANNNRTATCN_m1_c3	SIX1 (inferredBy_Orthology).
STXBP6	transfac_pro__M01282	PPARA (directAnnotation).
STXBP6	metacluster_23.2	ZNF506 (directAnnotation).
STXBP6	transfac_pro__M06845	ZBTB38 (directAnnotation).
STXBP6	metacluster_18.2	LCORL; NFIA; NFIA; NFIA; NFIB; NFIB; NFIB; NFIB; NFIB; NFIB; NFIB; NFIC; NFIC; NFIC; NFIC; NFIC; NFIC; NFIX; NFIX; NFIX; NFIX; NFIX; NFIX; NR2E1; SMAD1; TLX1; TLX1; ZNF300 (directAnnotation). NFIA; NFIB; NFIB; NFIC; NFIX (inferredBy_Orthology).
STXBP6	transfac_pro__M06552	ZNF420 (directAnnotation).
STXBP6	swissregulon__hs__LEF1	LEF1 (directAnnotation).
STXBP6	transfac_pro__M05498	SALL4 (directAnnotation).
STXBP6	metacluster_9.49	POU3F4 (inferredBy_Orthology).
STXBP6	taipale_tf_pairs__HOXB13_TBX3_NNNRTAAANNTNACACYN_CAP_repr	HOXB13; TBX3 (directAnnotation).
STXBP6	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
STXBP6	metacluster_9.22	HOXC5 (directAnnotation).
STXBP6	transfac_pro__M01267	FOSL1 (directAnnotation).
STXBP6	metacluster_0.5	ZNF264 (directAnnotation).
STXBP6	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
STXBP6	transfac_public__M00278	GATA1; LDB1; LMO2; TAL1; TCF3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."