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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SORBS2

Summary for SORBS2

Gene information	Gene symbol	SORBS2
	Ensembl ID	ENSG00000154556
	Entrez ID	8470
	Gene name	sorbin and SH3 domain containing 2
	Synonyms	ARGBP2\|KIAA0777
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SORBS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.368527	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.378223	2.98e-12
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.930553	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.292739	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.330577	3.25e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.402088	1.33e-20
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.0314	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.580278	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.648063	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.510427	0.00e+00

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Expression of SORBS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SORBS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SORBS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SORBS2	hsa-miR-4470	99.5589	NM_001145670
SORBS2	hsa-miR-3163	99.2468	NM_001145670
SORBS2	hsa-miR-4742-5p	98.8902	NM_001145670
SORBS2	hsa-let-7c-3p	98.5404	NM_001145670
SORBS2	hsa-miR-5692a	96.4361	NM_001145670
SORBS2	hsa-miR-1468-3p	96.4274	NM_001145670
SORBS2	hsa-miR-545-3p	96.3186	NM_001145670
SORBS2	hsa-miR-12136	95.4045	NM_001145670
SORBS2	hsa-miR-507	94.6015	NM_001145670
SORBS2	hsa-miR-3529-3p	94.4244	NM_001145670
SORBS2	hsa-miR-944	94.2282	NM_001145675
SORBS2	hsa-miR-3692-5p	94.1206	NM_001145670
SORBS2	hsa-miR-4325	93.9995	NM_001145670
SORBS2	hsa-miR-587	93.8347	NM_001145675
SORBS2	hsa-miR-4677-3p	93.5366	NM_001145675
SORBS2	hsa-miR-6071	92.8973	NM_001145670
SORBS2	hsa-miR-340-5p	92.3446	NM_001145675
SORBS2	hsa-miR-548p	91.9137	NM_001145670
SORBS2	hsa-miR-3680-3p	91.5955	NM_001145670
SORBS2	hsa-miR-557	91.4409	NM_001145670
SORBS2	hsa-miR-93-3p	91.3936	NM_001145670
SORBS2	hsa-miR-10527-5p	91.2943	NM_001145670
SORBS2	hsa-miR-216a-5p	91.1791	NM_001145670
SORBS2	hsa-miR-6511b-5p	90.462	NM_001145670
SORBS2	hsa-miR-6811-5p	90.462	NM_001145670
SORBS2	hsa-miR-12129	90.3582	NM_001145670
SORBS2	hsa-miR-1208	90.3432	NM_001145670
SORBS2	hsa-miR-3617-3p	88.2426	NM_001145675
SORBS2	hsa-miR-18b-5p	87.2361	NM_001145670
SORBS2	hsa-miR-18a-5p	87.2361	NM_001145670
SORBS2	hsa-miR-3127-5p	86.5936	NM_001145675
SORBS2	hsa-miR-320e	86.5869	NM_001145670
SORBS2	hsa-miR-3611	85.9021	NM_001145670
SORBS2	hsa-miR-374a-3p	85.3131	NM_001145675
SORBS2	hsa-miR-3907	85.3021	NM_001145670
SORBS2	hsa-miR-6760-3p	84.9785	NM_001145670
SORBS2	hsa-miR-196a-3p	84.8333	NM_001145670
SORBS2	hsa-miR-138-5p	84.6545	NM_001145670
SORBS2	hsa-miR-2278	84.6378	NM_001145670
SORBS2	hsa-miR-6505-5p	84.2123	NM_001145675
SORBS2	hsa-miR-4456	84.1473	NM_001145670
SORBS2	hsa-miR-4735-3p	83.7231	NM_001145670
SORBS2	hsa-miR-1246	83.3087	NM_001145675
SORBS2	hsa-miR-8485	82.7126	NM_001145670
SORBS2	hsa-miR-548t-3p	81.7229	NM_001145670
SORBS2	hsa-miR-548aa	81.7229	NM_001145670
SORBS2	hsa-miR-548ap-3p	81.7229	NM_001145670
SORBS2	hsa-miR-548k	81.5024	NM_001145670
SORBS2	hsa-miR-548av-5p	81.5024	NM_001145670
SORBS2	hsa-miR-8054	81.5024	NM_001145670

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Motifs and transcription factors (TFs) regulating SORBS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SORBS2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SORBS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SORBS2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
SORBS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SORBS2	hdpi__ETV4	ETV4 (directAnnotation).
SORBS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SORBS2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SORBS2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SORBS2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SORBS2	transfac_pro__M02090	E2F4 (directAnnotation).
SORBS2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
SORBS2	transfac_pro__M12604	ZNF444 (directAnnotation).
SORBS2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SORBS2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SORBS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SORBS2	transfac_pro__M02898	SMAD3 (directAnnotation).
SORBS2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
SORBS2	hdpi__TFAM	TFAM (directAnnotation).
SORBS2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SORBS2	metacluster_44.7	NKX3-2 (directAnnotation).
SORBS2	transfac_public__M00415	ZEB1 (directAnnotation).
SORBS2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SORBS2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SORBS2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SORBS2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SORBS2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SORBS2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
SORBS2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
SORBS2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SORBS2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SORBS2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SORBS2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
SORBS2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SORBS2	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SORBS2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SORBS2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SORBS2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SORBS2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
SORBS2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
SORBS2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
SORBS2	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
SORBS2	metacluster_183.4	ETS1 (inferredBy_Orthology).
SORBS2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
SORBS2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
SORBS2	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
SORBS2	cisbp__M08198	ELF1 (directAnnotation).
SORBS2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SORBS2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
SORBS2	transfac_pro__M04862	NRF1 (directAnnotation).
SORBS2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."