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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SELL

Summary for SELL

Gene information	Gene symbol	SELL
	Ensembl ID	ENSG00000188404
	Entrez ID	6402
	Gene name	selectin L
	Synonyms	CD62L\|hLHRc\|LAM-1\|LAM1\|Leu-8\|LNHR\|LSEL\|Lyam-1\|LYAM1\|PLNHR
	Gene type	protein_coding
	UniProtAcc	P14151

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Dataset with differentially expressed gene: SELL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.345151	2.80e-45
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.332823	1.17e-22
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.296375	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.253379	1.12e-35
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.337741	1.46e-29
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	-0.411394	8.57e-13
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.463532	2.11e-11
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.525723	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.464666	8.40e-13
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.268987	7.17e-15
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.441048	1.78e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	0.322027	1.21e-21
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	-0.311747	3.87e-17
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.491121	1.82e-19
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	NK cells	-0.776349	3.62e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.31893	1.16e-11
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD8+ T cells	-0.299668	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.274653	2.19e-24
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.745613	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.350835	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	-0.267347	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	-0.835894	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	-0.260675	1.01e-40
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-1.45203	1.12e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.792181	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.981046	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.420652	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	0.664622	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.306111	6.23e-21
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	0.40436	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	NK cells	0.49836	5.59e-12
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	NK cells	0.413903	4.38e-07

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Expression of SELL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SELL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SELL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SELL	hsa-miR-186-5p	89.6371	NM_000655
SELL	hsa-miR-6088	89.563	NM_000655
SELL	hsa-miR-4770	88.6303	NM_000655
SELL	hsa-miR-143-3p	88.6303	NM_000655
SELL	hsa-miR-105-5p	88.1325	NM_000655
SELL	hsa-miR-7853-5p	88.1325	NM_000655
SELL	hsa-miR-653-3p	86.865	NM_000655
SELL	hsa-miR-4279	85.4699	NM_000655
SELL	hsa-miR-92a-2-5p	84.892	NM_000655
SELL	hsa-miR-4533	83.8871	NM_000655
SELL	hsa-miR-4708-5p	83.8418	NM_000655
SELL	hsa-miR-4738-3p	80.9199	NM_000655

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Motifs and transcription factors (TFs) regulating SELL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SELL	transfac_pro__M04826	EP300 (directAnnotation).
SELL	transfac_pro__M01298	MECP2 (directAnnotation).
SELL	jaspar__MA0684.2	RUNX3 (directAnnotation).
SELL	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
SELL	transfac_pro__M05709	ZNF136 (directAnnotation).
SELL	transfac_pro__M05847	ZNF837 (directAnnotation).
SELL	kznf__ZNF18_Imbeault2017_OM_RCADE	ZNF18 (directAnnotation).
SELL	transfac_pro__M06857	ZNF611 (directAnnotation).
SELL	kznf__ZNF211_Imbeault2017_OM_RCADE	ZNF211 (directAnnotation).
SELL	homer__DGCACACGTG_MNT	MNT (directAnnotation).
SELL	transfac_pro__M02113	POU2AF1 (directAnnotation).
SELL	kznf__ZNF669_Najafabadi2015_ChIP-seq	ZNF669 (directAnnotation).
SELL	metacluster_9.39	BARX1 (directAnnotation).
SELL	transfac_pro__M06148	ZNF41 (directAnnotation).
SELL	metacluster_74.8	HNF1B (directAnnotation).
SELL	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
SELL	transfac_pro__M05887	ZNF837 (directAnnotation).
SELL	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
SELL	tfdimers__MD00076	HNF1A; HNF1B; PPARG (directAnnotation).
SELL	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAP	ELK3; HOXD12 (directAnnotation).
SELL	transfac_pro__M05379	ZNF740 (inferredBy_Orthology).
SELL	metacluster_145.9	POU6F1; POU6F1 (inferredBy_Orthology).
SELL	transfac_pro__M05626	ZNF780A (directAnnotation).
SELL	kznf__ZNF45_Imbeault2017_OM_RCADE	ZNF45 (directAnnotation).
SELL	taipale_tf_pairs__TEAD4_GSC2_RGWATGTTAATCCS_CAP_repr	GSC2; TEAD4 (directAnnotation).
SELL	metacluster_20.2	BARHL2; BARHL2 (directAnnotation).
SELL	tfdimers__MD00272	ISL1; POU3F1 (directAnnotation).
SELL	tfdimers__MD00231	HOXA13; RUNX3 (directAnnotation).
SELL	metacluster_130.12	ZNF182; ZNF35; ZNF674; ZNF677; ZNF79; ZNF836 (directAnnotation).
SELL	dbtfbs__ZNF513_HEK293_ENCSR503DPC_merged_N1	ZNF513 (directAnnotation).
SELL	jaspar__MA1956.1	FOXO1 (directAnnotation).
SELL	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
SELL	jaspar__MA1937.1	HOXB13 (directAnnotation).
SELL	taipale_tf_pairs__ETV2_HOXB13_NCCGGAAGTYRTAAAN_CAP	ETV2; HOXB13 (directAnnotation).
SELL	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTCGTAAAN_CAP	ETV4; HOXD12 (directAnnotation).
SELL	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTAATAAAN_CAP	ETV1; HOXD12 (directAnnotation).
SELL	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
SELL	transfac_pro__M06307	ZNF404 (directAnnotation).
SELL	transfac_pro__M06067	ZNF195 (directAnnotation).
SELL	transfac_pro__M06784	ZNF780B (directAnnotation).
SELL	homer__ATATGCAAAT_Oct2	POU2F2 (inferredBy_Orthology).
SELL	metacluster_97.2	GTF3A (inferredBy_Orthology).
SELL	transfac_pro__M06875	ZNF224 (directAnnotation).
SELL	metacluster_72.1	ZNF423; ZNF423 (directAnnotation).
SELL	transfac_pro__M05706	ZNF20 (directAnnotation).
SELL	swissregulon__hs__MYBL2	MYBL2 (directAnnotation).
SELL	cisbp__M00196	BBX (inferredBy_Orthology).
SELL	metacluster_126.11	ZNF286A (directAnnotation).
SELL	metacluster_172.3	SMAD7 (directAnnotation). SMAD7 (inferredBy_Orthology).
SELL	taipale_tf_pairs__GCM2_ONECUT2_RTRCGGGNNNNNNATCRATN_CAP_repr	GCM2; ONECUT2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."