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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAI14

Summary for RAI14

Gene information	Gene symbol	RAI14
	Ensembl ID	ENSG00000039560
	Entrez ID	26064
	Gene name	retinoic acid induced 14
	Synonyms	DKFZp564G013\|KIAA1334\|NORPEG\|RAI13
	Gene type	protein_coding
	UniProtAcc	Q9P0K7

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Dataset with differentially expressed gene: RAI14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.78646	2.19e-29
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.288738	5.17e-06
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.391317	5.47e-34
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.415426	1.68e-22
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.631483	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	1.78458	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.456789	0.00e+00

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Expression of RAI14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAI14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAI14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAI14	hsa-miR-570-3p	97.0894	NM_001145520
RAI14	hsa-miR-153-3p	96.581	NM_001145520
RAI14	hsa-miR-3714	95.7704	NM_001145520
RAI14	hsa-miR-12136	94.4448	NM_001145520
RAI14	hsa-miR-524-5p	93.6441	NM_001145520
RAI14	hsa-miR-520d-5p	93.6441	NM_001145520
RAI14	hsa-miR-502-3p	92.9168	NM_001145520
RAI14	hsa-miR-501-3p	92.9168	NM_001145520
RAI14	hsa-miR-506-3p	92.6024	NM_001145520
RAI14	hsa-miR-124-3p	92.6024	NM_001145520
RAI14	hsa-miR-513c-5p	92.3382	NM_001145520
RAI14	hsa-miR-514b-5p	92.3382	NM_001145520
RAI14	hsa-miR-767-5p	92.2651	NM_001145520
RAI14	hsa-miR-3686	92.1701	NM_001145520
RAI14	hsa-miR-3910	91.6911	NM_001145520
RAI14	hsa-miR-4511	91.3579	NM_001145520
RAI14	hsa-miR-4477b	91.0459	NM_001145520
RAI14	hsa-miR-30b-5p	90.8666	NM_001145520
RAI14	hsa-miR-30e-5p	90.8666	NM_001145520
RAI14	hsa-miR-30d-5p	90.8666	NM_001145520
RAI14	hsa-miR-30a-5p	90.8666	NM_001145520
RAI14	hsa-miR-30c-5p	90.8666	NM_001145520
RAI14	hsa-miR-552-5p	89.4468	NM_001145520
RAI14	hsa-miR-3680-3p	88.8042	NM_001145520
RAI14	hsa-miR-448	88.7437	NM_001145520
RAI14	hsa-miR-1283	88.6253	NM_001145520
RAI14	hsa-miR-1184	88.3553	NM_001145520
RAI14	hsa-miR-107	88.0972	NM_001145520
RAI14	hsa-miR-103a-3p	88.0972	NM_001145520
RAI14	hsa-miR-4804-3p	87.9006	NM_001145520
RAI14	hsa-miR-95-3p	86.7243	NM_001145520
RAI14	hsa-miR-3692-5p	86.3167	NM_001145520
RAI14	hsa-miR-4802-3p	85.1567	NM_001145520
RAI14	hsa-miR-23b-3p	85.114	NM_001145520
RAI14	hsa-miR-23c	85.114	NM_001145520
RAI14	hsa-miR-23a-3p	85.114	NM_001145520
RAI14	hsa-miR-655-5p	84.7913	NM_001145520
RAI14	hsa-miR-3646	83.7919	NM_001145520
RAI14	hsa-miR-6728-3p	83.7431	NM_001145520
RAI14	hsa-miR-6792-5p	82.71	NM_001145520
RAI14	hsa-miR-195-3p	82.0251	NM_001145520
RAI14	hsa-miR-16-2-3p	82.0251	NM_001145520
RAI14	hsa-miR-10399-5p	81.3705	NM_001145520
RAI14	hsa-miR-6504-3p	81.3705	NM_001145520
RAI14	hsa-miR-505-3p	81.0134	NM_001145520
RAI14	hsa-miR-3658	80.9425	NM_001145520
RAI14	hsa-miR-549a-5p	80.0749	NM_001145520
RAI14	hsa-miR-653-5p	80.0161	NM_001145520

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Motifs and transcription factors (TFs) regulating RAI14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAI14	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RAI14	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RAI14	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RAI14	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAI14	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
RAI14	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RAI14	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
RAI14	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RAI14	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RAI14	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
RAI14	cisbp__M08198	ELF1 (directAnnotation).
RAI14	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
RAI14	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
RAI14	jaspar__MA1957.1	ELK1 (directAnnotation).
RAI14	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAI14	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
RAI14	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAI14	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAI14	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAI14	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAI14	metacluster_3.14	WT1; WT1 (directAnnotation).
RAI14	cisbp__M07938	E2F1 (directAnnotation).
RAI14	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RAI14	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RAI14	transfac_pro__M04617	ZBTB7A (directAnnotation).
RAI14	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RAI14	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RAI14	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAI14	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RAI14	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAI14	transfac_pro__M07436	WT1 (directAnnotation).
RAI14	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RAI14	transfac_pro__M00716	ZBTB14 (directAnnotation).
RAI14	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAI14	hdpi__HIP2	UBE2K (directAnnotation).
RAI14	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RAI14	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAI14	transfac_pro__M04893	TAF1 (directAnnotation).
RAI14	transfac_pro__M03876	ZBTB33 (directAnnotation).
RAI14	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RAI14	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAI14	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAI14	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAI14	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAI14	transfac_pro__M04826	EP300 (directAnnotation).
RAI14	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RAI14	jaspar__MA0748.2	YY2 (directAnnotation).
RAI14	jaspar__MA1708.1	ETV7 (directAnnotation).
RAI14	hdpi__ELF2	ELF2 (directAnnotation).
RAI14	swissregulon__hs__ELK1	ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."