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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RAB5A

Summary for RAB5A

Gene information	Gene symbol	RAB5A
	Ensembl ID	ENSG00000144566
	Entrez ID	5868
	Gene name	RAB5A, member RAS oncogene family
	Synonyms	RAB5
	Gene type	protein_coding
	UniProtAcc	P20339

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Dataset with differentially expressed gene: RAB5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.309229	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.253861	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.360969	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.255533	5.66e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.268618	9.50e-31
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.434226	3.10e-28

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Expression of RAB5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB5A	hsa-miR-4671-3p	99.315	NM_001292048
RAB5A	hsa-miR-101-3p	99.2391	NM_001292048
RAB5A	hsa-miR-454-3p	95.9044	NM_001292048
RAB5A	hsa-miR-301b-3p	95.1835	NM_001292048
RAB5A	hsa-miR-3666	94.4555	NM_001292048
RAB5A	hsa-miR-130b-3p	94.4555	NM_001292048
RAB5A	hsa-miR-301a-3p	94.4555	NM_001292048
RAB5A	hsa-miR-4295	94.4555	NM_001292048
RAB5A	hsa-miR-130a-3p	94.4555	NM_001292048
RAB5A	hsa-miR-18a-5p	92.6689	NM_001292048
RAB5A	hsa-miR-18b-5p	92.6689	NM_001292048
RAB5A	hsa-miR-4492	91.969	NM_001292048
RAB5A	hsa-miR-301b-5p	91.6676	NM_001292048
RAB5A	hsa-miR-301a-5p	91.6676	NM_001292048
RAB5A	hsa-miR-4735-3p	91.6027	NM_001292048
RAB5A	hsa-miR-3121-3p	91.4254	NM_001292048
RAB5A	hsa-miR-4446-5p	90.7364	NM_001292048
RAB5A	hsa-miR-6504-3p	90.0698	NM_001292048
RAB5A	hsa-miR-10399-5p	90.0698	NM_001292048
RAB5A	hsa-miR-3663-3p	89.8347	NM_001292048
RAB5A	hsa-miR-4498	89.4872	NM_001292048
RAB5A	hsa-miR-1287-3p	88.6346	NM_001292048
RAB5A	hsa-miR-6730-3p	87.7932	NM_001292048
RAB5A	hsa-miR-206	87.7327	NM_001292048
RAB5A	hsa-miR-1-3p	87.7327	NM_001292048
RAB5A	hsa-miR-613	87.4209	NM_001292048
RAB5A	hsa-miR-20a-3p	86.6022	NM_001292048
RAB5A	hsa-miR-299-3p	85.3561	NM_001292048
RAB5A	hsa-miR-5692a	85.1679	NM_001292048
RAB5A	hsa-miR-539-5p	85.0837	NM_001292048
RAB5A	hsa-miR-4473	84.7032	NM_001292048
RAB5A	hsa-miR-762	84.3959	NM_001292048
RAB5A	hsa-miR-5001-5p	84.3959	NM_001292048
RAB5A	hsa-miR-4476	84.3165	NM_001292048
RAB5A	hsa-miR-6876-5p	84.3165	NM_001292048
RAB5A	hsa-miR-6868-3p	81.8804	NM_001292048
RAB5A	hsa-miR-1255b-2-3p	81.5294	NM_001292048
RAB5A	hsa-miR-3184-3p	81.1279	NM_001292048

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Motifs and transcription factors (TFs) regulating RAB5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB5A	metacluster_7.13	ZFX (directAnnotation).
RAB5A	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RAB5A	metacluster_151.2	ZNF23 (directAnnotation).
RAB5A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAB5A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB5A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RAB5A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB5A	hdpi__ETV4	ETV4 (directAnnotation).
RAB5A	jaspar__MA0748.2	YY2 (directAnnotation).
RAB5A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB5A	jaspar__MA1933.1	SREBF2 (directAnnotation).
RAB5A	jaspar__MA0079.5	SP1 (directAnnotation).
RAB5A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB5A	cisbp__M00968	MTF2 (directAnnotation).
RAB5A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB5A	cisbp__M00341	PAX6 (directAnnotation).
RAB5A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB5A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB5A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB5A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB5A	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB5A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB5A	metacluster_175.1	ZNF283 (directAnnotation).
RAB5A	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB5A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB5A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RAB5A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB5A	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB5A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB5A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB5A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB5A	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB5A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB5A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RAB5A	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RAB5A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RAB5A	transfac_pro__M00430	E2F1 (directAnnotation).
RAB5A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RAB5A	transfac_pro__M04893	TAF1 (directAnnotation).
RAB5A	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
RAB5A	hdpi__HIP2	UBE2K (directAnnotation).
RAB5A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB5A	hdpi__TIMELESS	TIMELESS (directAnnotation).
RAB5A	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RAB5A	metacluster_191.5	SPDEF (inferredBy_Orthology).
RAB5A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB5A	transfac_pro__M00938	E2F1 (directAnnotation).
RAB5A	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
RAB5A	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
RAB5A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RAB5A	"Guanosine-5'-Diphosphate"	DB04315	small molecule
RAB5A	"Guanosine-5'-Triphosphate"	DB04137	small molecule
RAB5A	"L-methionine (S)-S-oxide"	DB02467	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."