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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB3IP

Summary for RAB3IP

Gene information	Gene symbol	RAB3IP
	Ensembl ID	ENSG00000127328
	Entrez ID	117177
	Gene name	RAB3A interacting protein
	Synonyms	FLJ22548\|RABIN3\|RABIN8
	Gene type	protein_coding
	UniProtAcc	Q96QF0

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Dataset with differentially expressed gene: RAB3IP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.698603	1.00e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.257062	2.44e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.316725	3.62e-32
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.338578	0.00e+00

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Expression of RAB3IP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB3IP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB3IP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB3IP	hsa-miR-6867-5p	99.7534	NM_175623
RAB3IP	hsa-miR-7856-5p	96.0768	NM_175623
RAB3IP	hsa-miR-4262	92.3659	NM_175624
RAB3IP	hsa-miR-6868-3p	92.0459	NM_175623
RAB3IP	hsa-miR-450b-5p	91.9665	NM_175624
RAB3IP	hsa-miR-5580-3p	91.2769	NM_175623
RAB3IP	hsa-miR-181c-5p	90.1206	NM_175624
RAB3IP	hsa-miR-181d-5p	90.1206	NM_175624
RAB3IP	hsa-miR-181b-5p	90.1206	NM_175624
RAB3IP	hsa-miR-181a-5p	90.1206	NM_175624
RAB3IP	hsa-miR-5010-3p	89.6917	NM_175623
RAB3IP	hsa-miR-5581-3p	89.0166	NM_175623
RAB3IP	hsa-miR-4517	88.5821	NM_175623
RAB3IP	hsa-miR-493-5p	88.5574	NM_175623
RAB3IP	hsa-miR-4328	87.6162	NM_175623
RAB3IP	hsa-miR-4478	87.2532	NM_175623
RAB3IP	hsa-miR-330-5p	87.0699	NM_175623
RAB3IP	hsa-miR-7-2-3p	86.9821	NM_175623
RAB3IP	hsa-miR-7-1-3p	86.9821	NM_175623
RAB3IP	hsa-miR-5197-3p	86.9546	NM_175623
RAB3IP	hsa-miR-6792-5p	86.2036	NM_175623
RAB3IP	hsa-miR-10526-3p	85.5254	NM_175623
RAB3IP	hsa-miR-34a-3p	84.9834	NM_175623
RAB3IP	hsa-miR-326	84.9489	NM_175623
RAB3IP	hsa-miR-519d-5p	84.6524	NM_175623
RAB3IP	hsa-miR-664a-3p	84.284	NM_175623
RAB3IP	hsa-miR-30e-3p	84.2143	NM_175623
RAB3IP	hsa-miR-30a-3p	84.2143	NM_175623
RAB3IP	hsa-miR-30d-3p	84.2143	NM_175623
RAB3IP	hsa-miR-619-5p	82.9493	NM_175623
RAB3IP	hsa-miR-3157-5p	82.477	NM_175623
RAB3IP	hsa-miR-3059-5p	81.811	NM_175624
RAB3IP	hsa-miR-4729	81.7182	NM_175624
RAB3IP	hsa-miR-577	81.6954	NM_175623
RAB3IP	hsa-miR-6792-3p	81.3688	NM_175623
RAB3IP	hsa-miR-4691-5p	81.3688	NM_175623
RAB3IP	hsa-miR-4326	81.1041	NM_175624
RAB3IP	hsa-miR-124-5p	80.7484	NM_175624
RAB3IP	hsa-miR-7151-3p	80.7382	NM_175623
RAB3IP	hsa-miR-6881-3p	80.5534	NM_175624
RAB3IP	hsa-miR-515-5p	80.454	NM_175623
RAB3IP	hsa-miR-519e-5p	80.454	NM_175623
RAB3IP	hsa-miR-4310	80.181	NM_175623

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Motifs and transcription factors (TFs) regulating RAB3IP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB3IP	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAB3IP	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAB3IP	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB3IP	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB3IP	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAB3IP	metacluster_3.14	WT1; WT1 (directAnnotation).
RAB3IP	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RAB3IP	cisbp__M07938	E2F1 (directAnnotation).
RAB3IP	transfac_pro__M06035	ZNF749 (directAnnotation).
RAB3IP	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
RAB3IP	metacluster_52.11	ZNF184 (directAnnotation).
RAB3IP	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RAB3IP	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RAB3IP	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RAB3IP	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RAB3IP	transfac_pro__M04617	ZBTB7A (directAnnotation).
RAB3IP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RAB3IP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB3IP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RAB3IP	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAB3IP	transfac_pro__M07436	WT1 (directAnnotation).
RAB3IP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RAB3IP	transfac_pro__M00716	ZBTB14 (directAnnotation).
RAB3IP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAB3IP	hdpi__HIP2	UBE2K (directAnnotation).
RAB3IP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RAB3IP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAB3IP	transfac_pro__M04893	TAF1 (directAnnotation).
RAB3IP	transfac_pro__M03876	ZBTB33 (directAnnotation).
RAB3IP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RAB3IP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB3IP	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAB3IP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB3IP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAB3IP	metacluster_135.11	NR2C2 (directAnnotation).
RAB3IP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB3IP	tfdimers__MD00038	TFAP2C (directAnnotation).
RAB3IP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB3IP	metacluster_7.13	ZFX (directAnnotation).
RAB3IP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB3IP	cisbp__M00968	MTF2 (directAnnotation).
RAB3IP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB3IP	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB3IP	cisbp__M00341	PAX6 (directAnnotation).
RAB3IP	metacluster_198.3	ZFP64 (directAnnotation).
RAB3IP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB3IP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB3IP	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB3IP	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB3IP	cisbp__M00788	ZFY (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."