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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB22A

Summary for RAB22A

Gene information	Gene symbol	RAB22A
	Ensembl ID	ENSG00000124209
	Entrez ID	57403
	Gene name	RAB22A, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9UL26

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Dataset with differentially expressed gene: RAB22A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.37152	3.77e-18
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.250764	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.367877	4.90e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.342235	0.00e+00

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Expression of RAB22A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB22A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAB22A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAB22A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB22A	hsa-miR-211-5p	99.7885	NM_020673
RAB22A	hsa-miR-204-5p	99.7885	NM_020673
RAB22A	hsa-miR-4755-5p	99.547	NM_020673
RAB22A	hsa-miR-5006-3p	99.547	NM_020673
RAB22A	hsa-miR-302e	99.1015	NM_020673
RAB22A	hsa-miR-20b-5p	99.0503	NM_020673
RAB22A	hsa-miR-17-5p	99.0503	NM_020673
RAB22A	hsa-miR-519d-3p	99.0503	NM_020673
RAB22A	hsa-miR-106a-5p	99.0503	NM_020673
RAB22A	hsa-miR-106b-5p	99.0503	NM_020673
RAB22A	hsa-miR-20a-5p	99.0503	NM_020673
RAB22A	hsa-miR-93-5p	99.0503	NM_020673
RAB22A	hsa-miR-526b-3p	99.0372	NM_020673
RAB22A	hsa-miR-520e-3p	98.6258	NM_020673
RAB22A	hsa-miR-520b-3p	98.6258	NM_020673
RAB22A	hsa-miR-520a-3p	98.6258	NM_020673
RAB22A	hsa-miR-520c-3p	98.6258	NM_020673
RAB22A	hsa-miR-373-3p	98.4394	NM_020673
RAB22A	hsa-miR-372-3p	98.4394	NM_020673
RAB22A	hsa-miR-520d-3p	98.4394	NM_020673
RAB22A	hsa-miR-302b-3p	98.4322	NM_020673
RAB22A	hsa-miR-302a-3p	98.4322	NM_020673
RAB22A	hsa-miR-302d-3p	98.4322	NM_020673
RAB22A	hsa-miR-302c-3p	98.4322	NM_020673
RAB22A	hsa-miR-4499	97.0525	NM_020673
RAB22A	hsa-miR-5580-3p	96.2682	NM_020673
RAB22A	hsa-miR-548ar-3p	95.7965	NM_020673
RAB22A	hsa-miR-548a-3p	95.5787	NM_020673
RAB22A	hsa-miR-548f-3p	95.5712	NM_020673
RAB22A	hsa-miR-556-3p	95.1037	NM_020673
RAB22A	hsa-miR-579-3p	94.9416	NM_020673
RAB22A	hsa-miR-548e-3p	94.7647	NM_020673
RAB22A	hsa-miR-548az-3p	94.7647	NM_020673
RAB22A	hsa-miR-548bc	94.7647	NM_020673
RAB22A	hsa-miR-4446-5p	94.2647	NM_020673
RAB22A	hsa-miR-664b-3p	93.8803	NM_020673
RAB22A	hsa-miR-507	93.4179	NM_020673
RAB22A	hsa-miR-1910-5p	92.9562	NM_020673
RAB22A	hsa-miR-548az-5p	92.901	NM_020673
RAB22A	hsa-miR-548t-5p	92.901	NM_020673
RAB22A	hsa-miR-6832-3p	92.0947	NM_020673
RAB22A	hsa-miR-557	91.5718	NM_020673
RAB22A	hsa-miR-4494	91.1731	NM_020673
RAB22A	hsa-miR-3529-3p	89.8841	NM_020673
RAB22A	hsa-miR-4766-5p	89.3267	NM_020673
RAB22A	hsa-miR-223-5p	88.8589	NM_020673
RAB22A	hsa-miR-2053	88.0505	NM_020673
RAB22A	hsa-miR-627-3p	86.695	NM_020673
RAB22A	hsa-miR-520g-3p	86.6458	NM_020673
RAB22A	hsa-miR-520h	86.6458	NM_020673

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Motifs and transcription factors (TFs) regulating RAB22A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB22A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB22A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB22A	metacluster_3.14	WT1; WT1 (directAnnotation).
RAB22A	cisbp__M07938	E2F1 (directAnnotation).
RAB22A	transfac_pro__M04617	ZBTB7A (directAnnotation).
RAB22A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RAB22A	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RAB22A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB22A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RAB22A	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAB22A	transfac_pro__M07436	WT1 (directAnnotation).
RAB22A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RAB22A	transfac_pro__M00716	ZBTB14 (directAnnotation).
RAB22A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAB22A	hdpi__HIP2	UBE2K (directAnnotation).
RAB22A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RAB22A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAB22A	transfac_pro__M04893	TAF1 (directAnnotation).
RAB22A	transfac_pro__M03876	ZBTB33 (directAnnotation).
RAB22A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RAB22A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB22A	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAB22A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB22A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAB22A	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RAB22A	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAB22A	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RAB22A	cisbp__M02645	ETS1 (directAnnotation).
RAB22A	cisbp__M08198	ELF1 (directAnnotation).
RAB22A	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
RAB22A	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
RAB22A	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
RAB22A	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
RAB22A	transfac_pro__M06331	ZNF343 (directAnnotation).
RAB22A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB22A	metacluster_7.13	ZFX (directAnnotation).
RAB22A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB22A	cisbp__M00968	MTF2 (directAnnotation).
RAB22A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB22A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB22A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB22A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB22A	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB22A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB22A	metacluster_175.1	ZNF283 (directAnnotation).
RAB22A	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB22A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB22A	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB22A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB22A	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."